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| 1 | Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress显示文摘BACKGROUND:Liver ischemia reperfusion(IR)injury triggers a systemic inflammatory response and is the main cause of organ dysfunction and adverse postoperative outcomes after liver surgery.Pentoxifylline(PTX)and hypertonic saline solution(HTS)have been identified to have beneficial effects against IR injury.This study aimed to investigate if the addition of PTX to HTS is superior to HTS alone for the prevention of liver IR injury. | Vinicius Rocha-Santos Estela RR Figueira Joel A Rocha-Filho Ana MM Coelho Rafael Soraes Pinheiro Telesforo Bacchella Marcel CC Machado Luiz AC D'Albuquerque | 2015 | Hepatobiliary & Pancreatic Diseases International2015,14,2: | 3 |
| 2 | Pentoxifylline 通过 TNF- 合成和 TGF-1 基因表示的下面规定改进肝新生显示文摘 AIM:To investigate the mechanism of pentoxifylline(PTX)improvement in liver regeneration.RESULTS:Rats were randomized into 4 groups:Control rats;Sham-sham-operation rats;Saline-70% hepatectomy plus saline solution;PTX-70%hepatectomy plus PTX.At 2 and 6 h after hepatectomy,aspartate aminotransferase,alanine aminotransferase,tumor necrosis factor(TNF)-α and interleukin-6(IL-6)serum and hepatic tissue levels were determined.Tumor growth factor(TGF)-β1 gene expression in liver tissue was evaluated 24 h after hepatectomy by quantitative reverse transcriptase polymerase chain reaction analysis.Proliferation was analyzed by mitotic index and proliferating cell nuclear antigen(PCNA)staining 48 h after hepatectomy.RESULTS:TNF-α and IL-6 serum levels increased at 2 and 6 h after hepatectomy.At 2 h after hepatectomy serum PTX was reduced but not hepatic levels of TNF-α and IL-6.A decrease in liver TGF-β1 gene expression and an increase in mitotic index and PCNA after hepatectomy were observed in the PTX treatment group in comparison to the saline group.CONCLUSION:PTX improves liver regeneration by a mechanism related to down regulation of TNF-α production and TGF-β1 gene expression. | Rodrigo Bronze Martino Ana Maria Mendona Coelho Márcia Saldanha Kubrusly Regina Leito Sandra Nassa Sampietre Marcel Cerqueira Cesar Machado Telesforo Bacchella Luiz Augusto Carneiro D’Albuquerque | 2012 | World Journal of Gastrointestinal Surgery2012,4,6: | 2 |
| 3 | Frant' z tumor ( papillary epithelial and cystic neoplasms of the pancreas) : report of 3 cases显示文摘 | Machado MC da Cunha JE Bacchella T | 1993 | Rev Hosp Clin Fac Med Sao Paulo (Portuguese)1993,48,1: | 1 |
| 4 | Timing-dependent protection of hypertonic saline solution administration in experimental liver ischemia/reperfusion injury显示文摘 | Estela Regina Ramos Figueira Telesforo Bacchella Ana Maria Mendon?a Coelho Sandra Nassa Sampietre Nilza Aparecida Trindade Molan Regina Maria Cubero Leit?o Marcel Cerqueira Cesar Machado | 2010 | Surgery2010,,3: | 1 |
| 5 | Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients显示文摘 | Marcel C.C. Machado Marcel Autran C. Machado Telesforo Bacchella José Jukemura José L. Almeida José E.M. Cunha | 2008 | Surgery2008,,1: | 1 |
| 6 | Solid pseudopapillary tumor of the pancreas: distinct patterns of onset, diagnosis,and prognosis for male versus female patients显示文摘 | Machado M C Machado M A Bacchella T | 2008 | Surgery2008,143,: | 1 |
| 7 | Timing-dependent protection of hypertonic saline solution administration in experimental liver ischemia/reperfusion injury显示文摘 | Estela Regina Ramos Figueira Telesforo Bacchella Ana Maria Mendon?a Coelho Sandra Nassa Sampietre Nilza Aparecida Trindade Molan Regina Maria Cubero Leit?o Marcel Cerqueira Cesar Machado | 2010 | Surgery2010,,3: | 1 |
| 8 | Biliary reconstruction without T-tube in liver transplantation 显示文摘 | Bacchella T Figueira E R Makdissi FF | 2004 | Transpl Proc2004,36,4: | 1 |
| 9 | Hemihepatic ischemia for laparoscopic liver resection 显示文摘 | Machado MA Makdissi FF Bacchella T | 2005 | Surg Laparosc Endosc Percutan Tech2005,15,3: | 1 |
| 10 | Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients显示文摘 | Machado MC Machado MA Bacchella T | 2008 | Surgery2008,143,1: | 1 |
| 11 | Hemihepatic ischemia for laparoscopic liver resection显示文摘 | Machado MA Makdissi FF Bacchella T | 2005 | Surg Laparosc Endosc Percutan Tech2005,15,3: | 1 |
| 12 | Biliary reconstruction without T - tube in liver transplantation 显示文摘 | BACCHELLA T FIGUEIRA E R MAKDISSI F F | 2004 | Transplant Proc2004,36,4: | 1 |
| 13 | Laparoscopic right hemihepatectomy for hepatolithiasis显示文摘 | M. A. C. Machado F. F. Makdissi R. C. T. Surjan A. R. F. Teixeira A. Sepúlveda T. Bacchella M. C. C. Machado | 2008 | Surgical Endoscopy2008,,1: | 1 |
| 14 | Hemihepatic ischemia for laparoscopic liver resection显示文摘 | Machado M A Makdissi F F Bacchella T | 2005 | Surg Laparosc Endosc Percutan Tech2005,15,3: | 1 |
| 15 | Liver resection as the definitive treatment for unilateral non-oriental primary intrahepatic lithiasis显示文摘 | Paulo Herman Marcos V. Perini Marcel Autran C. Machado Telesforo Bacchella Vincenzo Pugliese William A. Saad Jose Eduardo M. da Cunha Marcel C.C. Machado Joaquim Gama Rodrigues | 2006 | The American Journal of Surgery2006,,4: | 1 |
| 16 | Hemihepatic ischemia for laparoscopic liver resection显示文摘 | Machado MA Makdissi FF Bacchella T | 2005 | Surg Laparosc Endosc Percutan Tech2005,15,3: | 1 |
| 17 | Biliary reconstruction without T-tube in liver transplantation 显示文摘 | Bacchella T Figueira ER Makdissi FF | 2004 | Transplant Proc2004,36,4: | 1 |
| 18 | Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients显示文摘 | Machado MC Machado MA Bacchella T | 2008 | Surgery2008,143,1: | 1 |
| 19 | Liver resection for the treatment of post-cholecystectomy biliary stricture with vascular injury显示文摘AIM:To report experience with liver resection in a select group of patients with postoperative biliary stricture associated with vascular injury.METHODS:From a prospective database of patients treated for benign biliary strictures at our hospital,cases that underwent liver resections were reviewed.All cases were referred after one or more attempts to repair bile duct injuries following cholecystectomy(open or laparoscopic).Liver resection was indicated in patients with Strasberg E3/E4(hilar stricture)bile duct lesions associated with vascular damage(arterial and/or portal),ipsilateral liver atrophy/abscess,recurrent attacks of cholangitis,and failure of previous hepaticojejunostomy.RESULTS:Of 148 patients treated for benign biliary strictures,nine(6.1%)underwent liver resection;eight women and one man with a mean age of 38.6 years.Six patients had previously been submitted to open cholecystectomy and three to laparoscopic surgery.The mean number of surgical procedures before definitive treatment was 2.4.All patients had Strasberg E3/E4injuries,and vascular injury was present in all cases.Eight patients underwent right hepatectomy and one underwent left lateral sectionectomy without mortality.Mean time of follow up was 69.1 mo and after longterm follow up,eight patients are asymptomatic.CONCLUSION:Liver resection is a good therapeutic option for patients with complex postoperative biliary stricture and vascular injury presenting with liver atrophy/abscess in which previous hepaticojejunostomy has failed. | Marcos V Perini Paulo Herman Andre L Montagnini Jose Jukemura Fabricio F Coelho Jaime A Kruger Telesforo Bacchella Ivan Cecconello | 2015 | World Journal of Gastroenterology2015,21,7: | 1 |
| 20 | A modified technique for the reconstruction of the alimentary tract after pancreatoduodenectomy 显示文摘 | Machado MC da Cunha JE Bacchella T | 1976 | Surg Gynecol Obstet1976,143,2: | 1 |