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| 1 | Imaging plaque inflammation in asymptomatic cocaine addicted individuals with simultaneous positron emission tomography/magnetic resonance imaging显示文摘BACKGROUND Chronic cocaine use is associated with stroke, coronary artery disease and myocardial infarction, resulting in severe impairments or sudden mortality. In the absence of clear cardiovascular symptoms, individuals with cocaine use disorder (iCUD) seeking addiction treatment receive mostly psychotherapy and psychiatric pharmacotherapy, with no attention to vascular disease (i.e., atherosclerosis). Little is known about the pre-clinical signs of cardiovascular risk in iCUD and early signs of vascular disease are undetected in this underserved population. AIM To assess inflammation, plaque burden and plaque composition in iCUD aiming to detect markers of atherosclerosis and vascular disease. METHODS The bilateral carotid arteries were imaged with positron emission tomography/magnetic resonance imaging (PET/MRI) in iCUD asymptomatic for cardiovascular disease, healthy controls, and individuals with cardiovascular risk. PET with 18F-fluorodeoxyglucose (18F-FDG) evaluated vascular inflammation and 3-D dark-blood MRI assessed plaque burden including wall area and thickness. Drug use and severity of addiction were assessed with standardized instruments. RESULTS The majority of iCUD and controls had carotid FDG-PET signal greater than 1.6 but lower than 3, indicating the presence of mild to moderate inflammation. However, the MRI measure of wall structure was thicker in iCUD as compared to the controls and cardiovascular risk group, indicating greater carotid plaque burden. iCUD had larger wall area as compared to the healthy controls but not as compared to the cardiovascular risk group, indicating structural wall similarities between the non-control study groups. In iCUD, wall area correlated with greater cocaine withdrawal and craving. CONCLUSION These preliminary results show markers of carotid artery disease burden in cardiovascular disease-asymptomatic iCUD. Broader trials are warranted to develop protocols for early detection of cardiovascular risk and preventive intervention in iCUD. | Keren Bachi Venkatesh Mani Audrey E Kaufman Nadia Alie Rita Z Goldstein Zahi A Fayad Nelly Alia-Klein | 2019 | World Journal of Radiology2019，11，5： | 2 |
| 2 | Human immunodeficiency virus type 1 protein gp120 causes neuronal cell death in the rat brain by activating caspases显示文摘 | Acquas E Bachis A Nosheny RL | 2004 | Neurotox Res2004，5，8： | 1 |
| 3 | Lenalidomide as salvage treatment for multiple myeloma relapsing after allogeneic hematopoietic stem cell transplantation:a report from the French Society of Bone Marrow and Cellular Therapy显示文摘 | Coman T Bachy E Michallet M | 2013 | Haematologica2013，98，5： | 1 |
| 4 | Chemokine receptors and neurotrophie factors : Potential therapy against AIDS dementia显示文摘 | Mocchetti I Bachis A Masliah E | 2008 | J Neurosci Res2008，86，2： | 1 |
| 5 | Lenalidomide as salvage treatment for multiple myeloma relapsing after allogeneic hematopoietic stem cell transplantation: a report from the SFGM-TC显示文摘 | Coman T Bachy E Michallet M | 2013 | Haematologica2013，98，： | 1 |
| 6 | Efficacy of integuseal for surgical skin preparation in children and adolescents undergoing scoliosis correction显示文摘 | Dromzee E Tribot-Laspiere Q Bachy M | 2012 | Spine(Phila Pa 1976)2012，37，21： | 1 |
| 7 | Efficacy of integuseal for surgical skin preparation in children and adolescents undergoing scoliosis correction显示文摘 | Dromzee E Tribot-Laspiere Q Bachy M | 2012 | Spine2012，37，21： | 1 |
| 8 | Early posttrans- plantation donor-derived invariant natural killer T-cell recoverypredicts the occurrence of acute graft-versus-host disease and overall survival显示文摘 | Rubio MT Moreira-Teixeira L Bachy E | 2012 | Blood2012，120，10： | 1 |
| 9 | Effect of wheat residue and tillage on Heterodera glycines and yield of double-crop soybean in Kentucky显示文摘 | Hershman D E Bachi P R | 1995 | Plant Dis1995，79，： | 1 |
| 10 | Mapping and characterization of multiple chromosomal factors in- volved in methicillin resistance in Staphylococcus aureus显示文摘 | BERGER BACHI B STRASSLE A GUSTAFSON J E | 1992 | An- timicrob Agents Chemother1992，36，7： | 1 |
| 11 | Chemokine receptors and neurotrophic factors: potential therapy against aids dementia? 显示文摘 | Mocchetti I Bachis A Masliah E | 2008 | J Neurosci Res2008，86，2： | 1 |
| 12 | Proteome study of human cerebrospinal fluid following traumatic brain injury indicates fibrin (ogen) degradation products as trauma-associated markers显示文摘 | Conti A Sanchez Ruiz Y Bachi A Beretta L Grandi E Beltramo M | 2004 | J Neurotrauma2004，21，7： | 1 |
| 13 | In-depth exploration of Hevea brasiliensis latex proteome and 'hidden allergens' via combinatorial peptide ligand libraries显示文摘 | D'amato A Bachi A Fasoli E | 2010 | Journal of Proteomics2010，73，7： | 1 |
| 14 | Early posttransplantation donor-derived invariantnatural killer T-cell recovery predicts the occurrence of acute graft-versus-host disease and overall survival显示文摘 | Rubio MT Moreira-Teixeira L Bachy E BouilliéM Milpied P Coman T | 2012 | Blood2012，120，10： | 1 |
| 15 | Synthesis of gamma- and delta- lactones by free-radical annelation of Se-phenyl sele- noearbonates 显示文摘 | Bachi M D Bosch E | 1992 | J Org Chem1992，57，： | 1 |
| 16 | Maintaining calcineurin inhibition after the diagnosis of post-transplant lymphoproliferative disorder improves renal graft survival 显示文摘 | Serre JE Michonneau D Bachy E | 2014 | Kidney Int2014，85，1： | 1 |
| 17 | Immune responses induced by Pelargonium sidoides extract in serum and nasal mucosa of atbletes after exhaustive exercise: modulation of secretory IgA, IL-6 and IL-15 显示文摘 | Luna LA Jr Bachi AL Novaes e Brito RR | 2011 | Phytomedicine2011，18，4： | 1 |
| 18 | Lenalidomide as salvage treatment for multiple myeloma relapsing after allogeneic hematopoietic stem cell transplantation:a report from the French Society of Bone Marrow and Cellular Therapy显示文摘 | Coman T Bachy E Michallet M | 2013 | Haematologica2013，98，5： | 1 |
| 19 | Time has come for immunotherapy in PTCL显示文摘 | Bachy E Coiffier B | 2014 | Blood2014，123，20： | 1 |
| 20 | Efficacy and safety of thalidomide in mantle cell lymphoma:results of the French ATU Program显示文摘 | Harel S Bachy E Haioun C | 2010 | Blood (ASH Annual Meeting Abstracts)2010，116，： | 1 |
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