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| 1 | Helicobacter pylori infection is not associated with nonalcoholic fatty liver disease显示文摘AIM: To determine whether Helicobacter pylori(H. pylori) infection confers a higher risk of Nonalcoholic fatty liver disease(NAFLD).METHODS: Healthy people who underwent health screening were analyzed retrospectively. Inclusion criteria were age ≥ 20 years, history of H. pylori infection, and recorded insulin level. Participants were classified as H. pylori positive or negative according to 13 C urea breath tests. NAFLD was defined using the hepatic steatosis index(HSI) and NAFLD liver fat score(NAFLD-LFS). Those with an HSI > 36 or NAFLD-LFS >-0.640 were considered to have NAFLD. Multivariable logistic regression was performed to identify risk factors for NAFLD.RESULTS: Three thousand six hundred and sixtythree people were analyzed and 1636(44.7%) were H. pylori positive. H. pylori infection was associated with older age, male gender, hypertension, higher body mass index, and a dyslipidemic profile. HSI differed significantly between H. pylori positive and negative subjects(median 33.2, interquartile range(IQR) 30.0-36.2 for H. pylori-positive vs median 32.6, IQR 29.8-36.0 for negative participants, P = 0.005), but NAFLD-LSF did not [median-1.7, IQR-2.4--0.7 vs median-1.8, IQR-2.4-(-0.7), respectively, P = 0.122]. The percentage of people with NAFLD did not differbetween infected and uninfected groups: HIS, 26.9% vs 27.1%, P = 0.173; NAFLD-LFS, 23.5% vs 23.1%, P = 0.778. H. pylori infection was not a risk factor, but C-reactive protein concentration and smoking were significant risk factors for NAFLD.CONCLUSION: H. pylori infection is not a risk factor for NAFLD as indicated by HSI or NAFLD-LFS. Prospective, large-scale studies involving liver biopsies should be considered. | Myong Ki Baeg Seung Kew Yoon Sun-Hye Ko Yong-Sun Noh In-Seok Lee Myung-Gyu Choi | 2016 | World Journal of Gastroenterology2016，22，8： | 12 |
| 2 | Increased liver markers are associated with higher risk of type 2 diabetes显示文摘AIM: To investigate the association between liver markers and the risk of type 2 diabetes(T2DM) and impaired fasting glucose(IFG).METHODS: A total of 8863 participants(3408 men and 5455 women) over 30 years of age were analyzed from the fifth Korean National Health and Nutrition Examination Survey(2010-2011). The associations of serum liver markers such as aspartate aminotransferase(AST), alanine aminotransferase(ALT), AST/ALT, and gamma-glutamyltransferase(GGT) with T2 DM and IFG were analyzed using logistic regression models. Participants were divided into sex-specific quartiles on the basis of liver markers.RESULTS: The prevalence of T2 DM and IFG were 11.3% and 18.3%. Increasing quartiles of ALT and GGT were positively and AST/ALT were negatively correlated with T2 DM and IFG. Analysis of the liver marker combinations showed that if any two or more markers were in the highest risk quartile, the risks of both T2 DM and IFG increased significantly. The risk was greatest when the highest ALT and GGT and lowest AST/ALT quartile were combined, with the riskof T2 DM at 3.21(95%CI: 1.829-5.622, P < 0.001) in men and 4.60(95%CI: 3.217-6.582, P < 0.001) in women. Men and women with the highest AST and ALT and lowest AST/ALT quartile had a 1.99 and 2.40 times increased risk of IFG.CONCLUSION: Higher levels of GGT and ALT and lower AST/ALT within the physiological range are independent, additive risk factors of T2 DM and IFG. | Sun-Hye Ko Myong Ki Baeg Kyung-Do Han Seung-Hyun Ko Yu-Bae Ahn | 2015 | World Journal of Gastroenterology2015，21，24： | 8 |
| 3 | Case of inappropriate ADH syndrome:Hyponatremia due to polyethylene glycol bowel preparation显示文摘Colonoscopic screening has been reported to reduce deaths from colorectal cancer.Adequate bowel preparation is essential for this and safety is an important issue in choosing the methods.Polyethylene glycol(PEG)is regarded as a safe method for cleansing,especially compared with oral sodium phosphate.Here,we present a case of hyponatremia caused by the syndrome of inappropriate antidiuretic hormone(ADH)syndrome after PEG precolonoscopic cleansing resulting in generalized tonic-clonic seizures.A 62-year-old women had ingested PEG for precolonoscopic bowel cleansing.While waiting for the colonoscopy,she developed a stuporous mentality and generalized tonic-clonic seizures,which did not correlate with brain magnetic resonance imaging.Her serum sodium level was 113 mEq per liter and laboratory analyses were consistent with inappropriate ADH syndrome.Her thyroid and adrenal functions were normal.There were no malignancies,infections,respiratory disorders or central nervous disorders and she had no history of taking either diuretics or other medications,which might have caused inappropriate ADH syndrome.She was treated with 3%hypertonic saline and showed a complete neurological recovery as her sodium levels recovered.Follow-up visits showed the patient to have a normal sodium level without neurologic deficits.This case shows that inappropriate ADH syndrome can be caused by PEG preparation,which implies that physicians have to be aware of the possible side effects of this colonic cleansing approach and mindful of the possible ensuing symptoms. | Sun-Hye Ko Chul-Hyun Lim Jae-Young Kim Seung Hun Kang Myong Ki Baeg Hyun Jin Oh | 2014 | World Journal of Gastroenterology2014，20，34： | 5 |
| 4 | A case of a duodenal duplication cyst presenting as melena显示文摘Duodenal duplication cysts are benign rare congenital anomalies reported mainly in the pediatric population,but seldom in adults.Symptoms depend on the type and location and can present as abdominal pain,distension,dysphagia or dyspepsia.They have been reported to be responsible for duodenal obstruction,pancreatitis and,in rare cases,gastrointestinal bleeding.We present a case of a duodenal duplication cyst in a 43-year-old man presenting as melena.Initial gastroduodenoscopy and colonoscopy did not reveal any bleeding focus.However,the patient began passing melena after 3 d,with an acute decrease in hemoglobin levels.Subsequent studies revealed a duplication cyst in the second portion of the duodenum which was surgically resected.Histology revealed a duodenal duplication cyst consisting of intestinal mucosa.There was no further bleeding and the patient recovered completely.In rare cases,duodenal duplication cysts might cause gastrointestinal bleeding and should be included in the differential diagnosis. | Seung Yeon Ko Sun Hye Ko Sungeun Ha Mi Sung Kim Hyang Mi Shin Myong Ki Baeg | 2013 | World Journal of Gastroenterology2013，19，38： | 2 |
| 5 | Effect of DA-9701 on gastric emptying in a mouse model: Assessment by ^(13)C-octanoic acid breath test显示文摘AIM:To evaluate the effects of DA-9701 on the gastric emptying of a solid meal using the 13C-octanoic acid breath test in a mouse model. METHODS:Male C57BL/6 mice aged > 8 wk and with body weights of 20-25 g were used in this study. The solid test meal consisted of 200 mg of egg yolk labeled with 1.5 L/g 13C-octanoic acid. The mice were placed in a 130 mL chamber flushed with air at a flow speed of 200 mL/min. Breath samples were collected for 6 h. The half-emptying time and lag phase were calculated using a modified power exponential model. To assess the reproducibility of the 13C-octanoic acid breath test, the breath test was performed two times at intervals of one week in ten mice without drug treatment. To assess the gastrokinetic effects of DA-9701, the breath test was performed three times in another twelve mice, with a randomized crossover sequence of three drug treatments:DA-9701 3 mg/kg, erythromycin 6 mg/kg, or saline. Each breath test was performed at an interval of one week. RESULTS:Repeatedly measured half gastric emptying time of ten mice without drug treatment showed 0.856 of the intraclass correlation coefficient for the half gastric emptying time (P = 0.004). The mean cumulative excretion curve for the 13C-octanoic acid breath test showed accelerated gastric emptying after DA-9701 treatment compared with the saline control (P = 0.028). The median half gastric emptying time after the DA-9701 treatment was significantly shorter than after the saline treatment [122.4 min (109.0-137.9 min) vs 134.5 min (128.4-167.0 min), respectively; P = 0.028] and similar to that after the erythromycin treatment [123.3 min (112.9-138.2 min)]. The lag phase, which was defined as the period taken to empty 15% of a meal, was significantly shorter after the DA-9701 treatment than after the saline treatment [48.1 min (44.6-57.1 min) vs 52.6 min (49.45-57.4 min), respectively; P = 0.049]. CONCLUSION:The novel prokinetic agent DA-9701 accelerated gastric emptying, assessed with repeated measurements in the same mouse using the 13Coctanoic acid breath test. Our findings suggest that DA-9701 has therapeutic potential for the treatment of functional dyspepsia. | Chul-Hyun Lim Myung-Gyu Choi Hyeyeon Park Myong Ki Baeg Jae Myung Park | 2013 | World Journal of Gastroenterology2013，19，27： | 2 |
| 6 | Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo 显示文摘 | Disbrow GL Baege AC Kierpiec KA | 2005 | Cancer Res2005，65，10： | 1 |
| 7 | Can axillary reverse map- ping avoid lymphedema in node positive breast cancer patients 显示文摘 | Tausch C Baege A Dietrich D | 2013 | Euro J Surg Oneol2013，39，8： | 1 |
| 8 | Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila显示文摘 | Baeg GH Perrimon N | 2000 | Curr Opin Cell Biol2000，12，2： | 1 |
| 9 | Microwave absorbing properties of sintered Ni-Zn ferrite 显示文摘 | Dae Hee Han Sung Baeg Cho | 1991 | IEEE Transactions on Magnetics1991，30，6： | 1 |
| 10 | Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless显示文摘 | Baeg GH Lin X Khare N | 2001 | Development2001，128，1： | 1 |
| 11 | Structure and properties of WCCrAlN superlattice films by cathodic arc ion plating process显示文摘 | Li H Y Han J G Baeg S H | | 0，，： | 1 |
| 12 | Dihydroartemisinln is cytotoxic to papillomavims - expressing epithelial cells in vitro and in vivo显示文摘 | Disbrow GL Baege AC Kierpiec KA | 2005 | Can- cer Res2005，65，10： | 1 |
| 13 | 查看详情显示文摘 | K J Baeg D Khim S W Jung | | 0，，40： | 1 |
| 14 | Dihydroartemisinin is cy- totoxic to papillomavirus - expressing epithelial ceils in vitro and in vivo 显示文摘 | Disbrow G L Baege A C Kierpiec K A | 2005 | Cancer Res2005，65，10： | 1 |
| 15 | Anger in elderly patients with depressive disorders 显示文摘 | Baeg S Wang SK Chee IS | 2011 | Psychiatry Investig2011，8，3： | 1 |
| 16 | Dihydroartemislnin is cytotoxic to papillomavirus-expressing epithelial ceils Invitro and in vivo显示文摘 | Schlegel R Disbrow GL Baege AC | 2005 | Cancer Res2005，65，10： | 1 |
| 17 | Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelia cells in vitro and in vivo 显示文摘 | Disbrow GL Baege AC Kierpiec KA | 2005 | Cancer Res2005，65，10： | 1 |
| 18 | Organic non-volatile memory based on pentacene field-effect transistors using a polymeric gate electret显示文摘 | BAEG K J NOH Y Y GHIM J | 2006 | Adv Mater2006，18，23： | 1 |
| 19 | Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of wingless 显示文摘 | Baeg GH Lin X Khare N | 2001 | Development2001，121，： | 1 |
| 20 | Polarity Effects of Polymer Gate Electrets on Non-Volatile Organic Field-Effect Transistor Memory显示文摘 | BAEG K J NOH Y Y GHIM J | 2008 | Adv Funct Mater2008，18，22： | 1 |
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