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| 1 | Is the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B?显示文摘AIM: To determine the association between the neutrophil to lymphocyte(N/L) ratio and the degree of liver fibrosis in patients with chronic hepatitis B(CHB) infection. METHODS: Between December 2011 and February 2013, 129 consecutive CHB patients who were admitted to the study hospitals for histological evaluation of chronic hepatitis B-related liver fibrosis were included in this retrospective study. The patients were divided into two groups based on the fibrosis score: individuals with a fibrosis score of F0 or F1 were included in the 'no/minimal liver fibrosis' group, whereas patients with a fibrosis score of F2, F3, or F4 were included in the 'advanced liver fibrosis' group. The Statistical Package for Social Sciences 18.0 for Windows was used to analyze the data. A P value of < 0.05 was accepted as statistically significant.RESULTS: Three experienced and blinded pathologists evaluated the fibrotic status and inflammatory activity of 129 liver biopsy samples from the CHB patients. Following histopathological examination, the 'no/minimal fibrosis' group included 79 individuals, while the 'advanced fibrosis' group included 50 individuals. Mean(N/L) ratio levels were notably lower in patients with advanced fibrosis when compared with patients with no/minimal fibrosis. The mean value of the aspartate aminotransferase-platelet ratio index was markedly higher in cases with advanced fibrosis compared to those with no/minimal fibrosis.CONCLUSION: Reduced levels of the peripheral blood N/L ratio were found to give high sensitivity, specificity and predictive values in CHB patients with significant fibrosis. The prominent finding of our research suggests that the N/L ratio can be used as a novel noninvasive marker of fibrosis in patients with CHB. | Murat Kekilli Alpaslan Tanoglu Yusuf Serdar Sakin Mevlut Kurt Serkan Ocal Sait Bagci | 2015 | World Journal of Gastroenterology2015，21，18： | 15 |
| 2 | Effects of dexmedetomidine and dexketoprofen on the conduction block of rat sciatic nerve显示文摘Dexmedetomidine is a selective α2-adrenoceptor agonist that is used because of its sedative,anxiolytic,and analgesic effects.Dexketoprofen,which is used as an analgesic,is a nonselective nonsteroidal anti-inflammatory drug (NSAID).The use of dexmedetomidine and dexketoprofen as adjuvants to local anesthetics for the peripheral nerve is gradually increasing.In this study,we aimed to investigate the effects of different doses of dexmedetomidine and dexketoprofen on conduction block of rat sciatic nerve.The isolated sciatic nerve from adult rats was transferred to a nerve chamber.The compound action potentials (CAPs) were recorded from stimulated nerve with electrophysiological methods.Dexmedetomidine (n = 8) and dexketoprofen (n = 8) were administered in the chamber with cumulative concentrations of 10–9 to 10–5 M,and the CAPs were recorded for 5 and 10 minutes.The CAP parameters were calculated.Both dexmedetomidine and dexketoprofen significantly depressed all CAP parameters in a dose-dependent manner compared with the control group,i.e.,the group in which rats did not receive treatment.CAP parameters showed there was no significant difference in nerve conduction inhibition between dexmedetomidine and dexketoprofen.Higher doses of dexmedetomidine suppressed the conduction in the fast-conducting fibers;however,dexketoprofen was found to suppress the conduction in the slow-conducting fibers in a time-dependent manner and suppress the conduction in the medium- and slow-conducting fibers in a dose-dependent manner.These findings suggest that dexmedetomidine and dexketoprofen exhibit better anesthetic effects on peripheral nerve through different ways of action.The experimental procedures were approved by the Necmettin Erbakan University on January 30,2013 (approval No.2013-024). | Sengal Bagci Taylan Hulagu Bariskaner | 2020 | Neural Regeneration Research2020，15，5： | 8 |
| 3 | H pylori iceA alleles are disease-specific virulence factors显示文摘AIM: To characterize and compare genotype profiles of H pylori strains isolated from patients with chronic gastritis and duodenal ulcer in western part of Turkey. METHODS: A total of 46 patients [30 chronic gastritis (CG) and 16 duodenal ulcer (DU)] who had undergone endoscopy because of dyspeptic complaints were studied. The antral biopsy specimens were evaluated for the presence of H pylori by rapid urease test and culture, and the genotype profiles were determined by real-time PCR. RESULTS: The cagA gene was observed in 43 (93.5%) isolates. The vacA s1m2 genotype was the predominant subtype, found in 63.3% and 68.7% of isolates in patients with CG and DU, respectively. Twenty (66.6%) isolates from patients with CG were iceA2 positive while the iceA1 was predominant in those with DU (68.8%). In terms of the association of the iceA alleles to other genes, both alleles were significantly associated with the cagA vacA s1m2 genotype. CONCLUSION: The prevalent circulating genotypes in CG and DU were cagA vacA s1m2 iceA2 and cagA vacA s1m2 iceA1 genotype, respectively. It was found that cagA vacA s1m2 genotype seems to be common virulence factors in both CG and DU while iceA alleles show specificity for gastroduodenal pathologies in this study. | Vildan Caner Mustafa Yilmaz Nadir Yonetci Sevil Zencir Nedim Karagenc Ilknur Kaleli Huseyin Bagci | 2007 | World Journal of Gastroenterology2007，13，18： | 8 |
| 4 | Therapeutic effect of caffeic acid phenethyl ester on cerulein-induced acute pancreatitis显示文摘AIM: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of ceruleaninduced acute pancreatitis (AP).METHODS: Seventy male Wistar albino rats were divided into seven groups. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 μg/kg) four times at 1-h intervals. CAPE (30 mg/kg) was given by subcutaneous injection at the beginning (CAPE 1 group) and 12 h after the last cerulein injection (CAPE 2 group). Serum amylase, lipase, white blood cell count, and tumor necrosis factor (TNF)-α levels were measured, and pancreatic histopathology was assessed. RESULTS: In the AP group, amylase and lipase levels were found to be elevated and the histopathological evaluation showed massive edema and inflammation of the pancreas, with less fatty necrosis when compared with sham and control groups. Amylase and lipase levels and edema formation decreased signif icantly in the CAPE therapy groups (P < 0001); especially in the CAPE 2 group, edema was improved nearly completely (P = 0001). Inflammation and fatty necrosis were partially recovered by CAPE treatment. The pathologicalresults and amylase level in the placebo groups were similar to those in the AP group. White blood cell count and TNF-α concentration was nearly the same in the CAPE and placebo groups.CONCLUSION: CAPE may be useful agent in treatment of AP but more experimental and clinical studies are needed to support our observation of benef icial effects of CAPE before clinical usage of this agent. | Mehmet Buyukberber M Cemil Savas Cahit Bagci Mehmet Koruk Murat T Gulsen Ediz Tutar Tugba Bilgic Nurdan Ceylan | 2009 | World Journal of Gastroenterology2009，15，41： | 4 |
| 5 | In-situ combustion laboratory studies of Turkish heavy oil reservoirs显示文摘 | Bagci S Kok M V | 2001 | Fuel Processing Technology2001，74，2： | 2 |
| 6 | Efficacy of a Modified Sequential Therapy Including Bismuth Subcitrate as First‐Line Therapy to Eradicate H elicobacter pylori in a Turkish Population显示文摘 | Ahmet Uygun A. Melih OZEL Bulent Sivri Zulfikar Polat Halil Gen? Yusuf Serdar Sakin Gürkan ?elebi Oya Uygur‐Bayrami?li Cemal Nuri Er?in Abdurrahman Kadayif?i Ozdes Emer Armagan Gunal Sait Bagci | 2012 | Helicobacter2012，，6： | 2 |
| 7 | SOX4 expression levels in urothelial bladder carcinoma 显示文摘 | Gunes S Yegin Z Sullu Y Buyukalpelli R Bagci H | 2011 | Pathol Res Pract2011，207，7： | 1 |
| 8 | Medical image segmentation by combining graph cuts and oriented active appearance mndels 显示文摘 | Chen X Udupa 1 K Bagci U | 2012 | IEEE Transaction on Image Processing (S1057-7149)2012，21，4： | 1 |
| 9 | Bist ability in apoptosis:roles of bax,bcl-2,and mitochondrial permeability transition pores显示文摘 | Bagci EZ Vodovotz Y Billiar TR | 2006 | Biophys J2006，90，： | 1 |
| 10 | Effect of different adsorbents on purification of used sunflower seed oil utilized for frying 显示文摘 | MASKAN M BAGCI H | 2003 | Eur Food Res Technol2003，217，： | 1 |
| 11 | Autocrine semaphorin 3A signaling promotes glioblastoma dispersal显示文摘 | Bagci T Wu JK Pfannl R | 2009 | Oncogene2009，28，40： | 1 |
| 12 | Evaluation of candidate vaccine approaches for mers-cov显示文摘 | Wang L Shi W Joyce M G Modjarrad K Zhang Y Leung K Lees C R Zhou T Yassine H M KanekiyoM Yang Z Y Chen X Becker M M Freeman M Vogel L Johnson J C Olinger G Todd J P Bagci U Solomon J Mollura D J Hensley L Jahrling P Deni- son M R Rao S S Subbarao K Kwong P D Mascola J R Kong W P Graham B S | 2015 | Nat Commun2015，6，： | 1 |
| 13 | Metastasis from breast carcinoma to endometrial polyp显示文摘 | AYDIN O BAGCI P AKYILDIZ EU | 2008 | Eur J Gynaecol Oncol2008，29，6： | 1 |
| 14 | Moving object detection using adaptive subband decomposition and fractional lower order statistics in video sequences显示文摘 | BAGCI M YARDIMCI Y CETIN A E | 2002 | Signal Process2002，82，12： | 1 |
| 15 | Communication/ Computation Tradeoffs for Prolonging Network Lifetime in Wireless Sensor Networks: The Case of Digital Signatures 显示文摘 | Bicakci K Bagci I E Tavli B | 2012 | Information Sciences2012，188，1： | 1 |
| 16 | Silicon increases boron tolerance and reduces oxidative damage of wheat grown in soil with excess boron 显示文摘 | Gunes A Inal A Bagci E G | 2007 | Biologia Plantarum2007，51，3： | 1 |
| 17 | Reverse engineering application recovery of broken or worn parts for and re-manufacturing: the case studies显示文摘 | Eyup Bagci | 2009 | Advances in Engineering Software2009，，40： | 1 |
| 18 | Shaking Force and Shaking Moment Balancing of the Plane Silder - Crack Mechanism 显示文摘 | Bagci C | 1975 | Proceedings of 4th OSU Applied Mechanisms Conference Oklahoma1975，25，： | 1 |
| 19 | Medieal image segmentation by combining graph cuts and oriented active appearance models显示文摘 | Chen X Udupa J K Bagci U | 2012 | IEEE Transactions on Image Processing2012，21，4： | 1 |
| 20 | MOFCA:Multi-objective fuzzy clustering algorithm for wireless sensor networks显示文摘 | Seyyit Alper Sert Hakan Bagci Adnan Yazici | 2015 | Applied Soft Computing2015，30，6： | 1 |
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