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| 1 | Laparoscopic splenectomy:Current concepts显示文摘Since early 1990's,when it was inaugurally introduced,laparoscopic splenectomy has been performed with excellent results in terms of intraoperative and postoperative complications.Nowadays laparoscopic splenectomy is the approach of choice for both benign and malignant diseases of the spleen.However some contraindications still apply.The evolution of the technology has allowed though,cases which were considered to be absolute contraindications for performing a minimal invasive procedure to be treated with modified laparoscopic approaches.Moreover,the introduction of advanced laparoscopic tools for ligation resulted in less intraoperative complications.Today,laparoscopic splenectomy is considered safe,with better outcomes in comparison to open splenectomy,and the increased experience of surgeons allows operative times comparable to those of an open splenectomy.In this review we discuss the indications and the contraindications of laparoscopic splenectomy.Moreover we analyze the standard and modified surgical approaches,and we evaluate the short-term and long-term outcomes. | Evangelos P Misiakos George Bagias Theodore Liakakos Anastasios Machairas | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 14 |
| 2 | Concept of histone deacetylases in cancer:Reflections on esophageal carcinogenesis and treatment显示文摘Esophageal cancer (EC) presents a high mortality rate, mainly due to its aggressive nature. Squamous cell carcinoma is the most common histological type world-wide, though, a continuous increase in esophageal adenocarcinomas has been noted in the past decades. Common risk factors associated with EC include smoking, alcohol consumption, gastroesophageal reflux disease, Barrett's esophagus and obesity. In an effort to overcome chemotherapy resistance in oncology, it was discovered that histone acetylation/deacetylation equilibrium is altered in carcinogenesis, leading to changes in chromatin structure and altering expression of genes important in the cell cycle, differentiation and apoptosis. Based on this knowledge, histone acetylation was addressed as a potential novel chemotherapy drug target to repress cancer cell proliferation. There are four classes of histone deacetylases (HDACs) inhibitors with a variety of different mechanisms of actions that render them possible anticancer drugs. They arrest the cell cycle, inhibit differentiation and angiogenesis and induce apoptosis. They do not necessarily act on histone proteins, since they can also exert indirect anti-cancer effects, by modifying various cellular proteins.In addition,HDACs have also been associated with increased chemotherapy resistance.Based on the literature,HDACs have been associated with EC,with surveys revealing that increased expression of certain HDACs correlates with advanced TNM stages,tumor grade,metastatic potential and decreased 5-year overall and disease-free survival.The aim of this survey is to elucidate the molecular identity and mechanism of action of HDAC inhibitors as well as verify their potential utility as anti-cancer agents in esophageal cancer. | Dimitrios Schizas Aikaterini Mastoraki Leon Naar Eleftherios Spartalis Diamantis I Tsilimigras Georgia-Sofia Karachaliou George Bagias Dimitrios Moris | 2018 | World Journal of Gastroenterology2018，24，41： | 3 |
| 3 | Management of primary retroperitoneal synovial sarcoma: A case report and review of literature显示文摘BACKGROUND Synovial sarcoma(SS) is a rare type of soft tissue sarcoma that is usually developed from areas where synovial tissue exists, especially at the extremities.Nevertheless, several cases of retroperitoneal SS(RSS) have been described. We herein report a case of RSS presented in our institution.CASE SUMMARY A 69-year-old female patient was admitted with a large, palpable, firm mass in the right abdominal space SS. Computerized tomography scan depicted a concentric, sharply marinated retro-peritoneal lesion which was displacing the right kidney and the lower edge of the liver. Subsequently, the patient underwent surgical excision of the mass with additional right nephrectomy and resection of the right adrenal gland and a part of the diaphragm. The final histological diagnosis of the tumour was grade II monophasic RSS.CONCLUSION RSS is encountered in the biphasic type, the monophasic fibrous, and the monophasic epithelial category as well. Relevant clinical manifestations are not always documented at early stages. Therefore, the final diagnosis is posed after complete histological examination taking into consideration the results of immunochemistry and genetic analysis. Therapeutic approach happens often late when metastases at the lungs and the liver are apparent. Thus, 5-year survival rates remain low. | Aikaterini Mastoraki Dimitrios Schizas Ioannis S Papanikolaou George Bagias Nikolaos Machairas George Agrogiannis Theodore Liakakos Nikolaos Arkadopoulos | 2019 | World Journal of Gastrointestinal Surgery2019，11，1： | 2 |
| 4 | Renal impairment in hepatic cryotherapy显示文摘 | Bagia JS Perera DS Morris DL | 1998 | Cryobiology1998，36，4： | 1 |
| 5 | Mirizi syndrome:an extra hazard for laparoscopic surgery显示文摘 | Bagia JS Novth L Huat DR | 2001 | ANZJ Surg2001，71，： | 1 |
| 6 | Mirizzi syndrome: an extra hazard for laparoscopic surgery显示文摘 | Bagia JS North L Hunt DR | 2001 | ANZ J Surg2001，71，7： | 1 |
| 7 | Mirizzi syndrome:an extra hazard for laparoscopic surgery显示文摘 | North L Hunt DR | 2001 | ANZ Journal of Surgery2001，71，7： | 1 |
| 8 | Correlating ethylene glycol reforming activitywith in situ EXAFS detection of Ni segregation in supported NiPt bimetallic catalysts显示文摘 | TUPY S A KARIM A M BAGIA C DENG W HUANG Y VLACHOS D G CHEN J G | 2012 | ACS Catal2012，2，11： | 1 |
| 9 | Mifizzi syndrome: An extra hazard for laparoscopic surgery显示文摘 | Bagia JS North L Hunt DR | 2001 | ANZ J Surg2001，71，7： | 1 |
| 10 | Mirizzi syndrome: an extra hazard for laparoscopic surgery显示文摘 | Bagia JS North L Hunt DR | 2001 | ANZ J Surg2001，71，7： | 1 |
| 11 | Mirizzi syndrome: an extra hazard for laparoscopic surgery显示文摘 | Bagia JS North L Hunt DR | 2001 | ANZJ Stag2001，71，7： | 1 |
| 12 | Synthesis and evaluation of molecularly imprinted polymers for enalapril and lisinopril, two synthetic peptide anti-hypertensive drugs 显示文摘 | Theodoridis G Konsta G Bagia C | 2004 | J Chromat B2004，804，1： | 1 |
| 13 | MIrizzi syndrome:an extra hazard for laparoscopic surgery显示文摘 | North L Hunt DR | 2001 | ANZ Journal of Surgery2001，71，7： | 1 |
| 14 | Mirizzi syndrome:an extra hazard for loparoscopic surgery显示文摘 | Bagia J S Novth L Huat D R | 2001 | ANZJ Surg2001，71，5： | 1 |
| 15 | Mirizzi syndrome: an extra hazard for loparoscopic surgery显示文摘 | Bagia JS North L Huat DR | 2001 | ANZJ Surg2001，71，： | 1 |
| 16 | Evaluation of three methods used in the prophylaxis of cyclophosphamide induced hemorrhagic cystitis in bone marrow transplant patients显示文摘 | Krass I Bajorek B Bagia M | 1997 | J Oncol Pharm Pract1997，3，： | 1 |
| 17 | Mirizzi syndrome : an extra hazard for loparoscopic surgery显示文摘 | Bagia JS Novth L Huat DR | 2001 | ANZJ Surg2001，71，： | 1 |
| 18 | Mirizzi syndrome:an extra hazard for laparoscopic surgery显示文摘 | Bagia JS North L Hunt DR | 2001 | ANZ J Surg2001，71，7： | 1 |
| 19 | Cardiac electrophysiological effects of citalopram in guinea pig papillary muscle comparison with clomipramine 显示文摘 | Pachera P Bagia Z Lako'-Futo' Z | 2000 | Gen Pharmacol2000，34，： | 1 |
| 20 | Mirizzi syndrome:an extra hazard for loparoscopie surgery显示文摘 | Huat DR | 2001 | ANZJ Surg2001，71，： | 1 |
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