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| 1 | Introducing an enhanced recovery after surgery program in colorectal surgery:A single center experience显示文摘AIM:To study the implementation of an enhanced recovery after surgery(ERAS)program at a large University Hospital from'pilot study'to'standard of care'.METHODS:The study was designed as a prospective single centre cohort study.A prospective evaluation of compliance to a protocol based on full application of all ERAS principles,through the progressive steps of its implementation,was performed.Results achieved in the initial pilot study conducted by a dedicated team(n=47)were compared to those achieved in the shared protocol phase(n=143)three years later.Outcomes were length of postoperative hospital stay,readmission rate,compliance to the protocol and morbidity.Primary endpoint was the description of the results and the identification of critical issues of large scale implementation of an ERAS program in colorectal surgery emerged in the experience of a single center.Secondary endpoint was the identification of interventions that have been proven to be effective for facilitating the transition from traditional care pathways to a multimodal management protocol according to ERAS principles in colorectal surgery at a single center.RESULTS:During the initial pilot study(March 2009 to December 2010;47 patients)conducted by a dedicated multidisciplinary team,compliance to the items of ERAS protocol was 93%,with a median length of hospital stay(LOS)of 3 d.Early anastomotic fistulas were observed in 2 cases(4.2%),which required reoperation(Clavien-Dindo gradeⅢb).None of the patients had been discharged before the onset of the complication,which could therefore receive prompt treatment.There were also four(8.5%)minor complications(ClavienDindo gradeⅡ).Thirty days readmission rate was 4%.Perioperative mortality was nil.After implementation of the protocol throughout the Hospital in unselected patients(May 2012 to December 2012;147 patients)compliance was 74%,with a median LOS of 6 d.Early anastomotic fistulas were observed in 11 cases(7.7%),5(3.5%)of which required reoperation(Clavien-Dindo gradeⅢb).Two early anastomotic fistulas were treated by radiologic/endoscopic manoeuvres and 4 were treated conservatively.There were also 36(25.2%)minor complications,21(14.7%)of which were Clavien-Dindo gradeⅡand 15(10.5%)of which were Clavien-Dindo gradeⅠ.Only two patients whose course was adversely affected by the development of an anastomotic leak had been discharged before the onset of the complication itself,requiring readmission.Readmission rate within 30 d was 4%.Perioperative mortality was 1%.CONCLUSION:Our results confirm that introduction of an ERAS protocol for colorectal surgery allows quickerpostoperative recovery and shortens the length of stay compared to historical series. | Stefano Bona Mattia Molteni Riccardo Rosati Ugo Elmore Pietro Bagnoli Roberta Monzani Monica Caravaca Marco Montorsi | 2014 | World Journal of Gastroenterology2014，20，46： | 30 |
| 2 | 芙蓉统和排碧阶底界全球层型剖面的牙形刺生物地层显示文摘寒武系芙蓉统和排碧阶全球层型剖面——湖南花垣排碧剖面底界界线层的牙形刺生物地层,由下至上划分为Westergaardodina tetragonia带、Westergaardodina matsushitai带和Westergaardodina bicuspidate 3个牙形刺带,可与该界线层的三叶虫带进行很好对比;同时讨论了芙蓉统和排碧阶底界划在牙形刺Westergaardodina mat-sushitai带和Westergaardodina bicuspidata带之间的合理性;此外,还将该牙形刺分带与华北和东北地区寒武系牙形刺带进行了对比。 | 祁玉平 王志浩 Gabriella Bagnoli | 2004 | 地层学杂志2004，28，2： | 16 |
| 3 | Key nodes of a micro RNA network associated with the integrated mesenchymal subtype of high-grade serous ovarian cancer显示文摘Metastasis is the main cause of cancer mortality. One of the initiating events of cancer metastasis of epithelial tumors is epithelial-to-mesenchymal transition(EMT), during which cells dedifferentiate from a relatively rigid cell structure/morphology to a flexible and changeable structure/morphology often associated with mesenchymal cells. The presence of EMT in human epithelial tumors is reflected by the increased expression of genes and levels of proteins that are preferentially present in mesenchymal cells. The combined presence of these genes forms the basis of mesenchymal gene signatures, which are the foundation for classifying a mesenchymal subtype of tumors. Indeed, tumor classification schemes that use clustering analysis of large genomic characterizations, like The Cancer Genome Atlas(TCGA), have defined mesenchymal subtype in a number of cancer types, such as high-grade serous ovarian cancer and glioblastoma. However, recent analyses have shown that gene expression-based classifications of mesenchymal subtypes often do not associate with poor survival. This 'paradox' can be ameliorated using integrated analysis that combines multiple data types. We recently found that integrating m RNA and micro RNA(mi RNA) data revealed an integrated mesenchymal subtype that is consistently associated with poor survival in multiple cohorts of patients with serous ovarian cancer. This network consists of 8 major mi RNAs and 214 m RNAs. Among the 8 mi RNAs, 4 are known to be regulators of EMT. This review provides a summary of these 8 mi RNAs, which were associated with the integrated mesenchymal subtype of serous ovarian cancer. | Yan Sun Fei Guo Marina Bagnoli Feng-Xia Xue Bao-Cun Sun Ilya Shmulevich Delia Mezzanzanica Ke-Xin Chen Anil K. Sood Da Yang Wei Zhang | 2015 | Chinese Journal of Cancer2015，34，1： | 10 |
| 4 | Robotic rectal surgery: State of the art显示文摘Laparoscopic rectal surgery has demonstrated its superiority over the open approach, however it still has some technical limitations that lead to the development of robotic platforms. Nevertheless the literature on this topic is rapidly expanding there is still no consensus about benefits of robotic rectal cancer surgery over the laparoscopic one. For this reason a review of all the literature examining robotic surgery for rectal cancer was performed. Two reviewers independently conducted a search of electronic databases(Pub Med and EMBASE) using the key words 'rectum', 'rectal', 'cancer', 'laparoscopy', 'robot'. After the initial screen of 266 articles, 43 papers were selected for review. A total of 3013 patients were included in the review. The most commonly performed intervention was low anterior resection(1450 patients, 48.1%), followed by anterior resections(997 patients, 33%), ultra-low anterior resections(393 patients, 13%) and abdominoperineal resections(173 patients, 5.7%). Robotic rectal surgery seems to offer potential advantages especially in low anterior resections with lower conversions rates and better preservation of the autonomic function. Quality of mesorectum and status of and circumferential resection margins are similar to those obtained with conventional laparoscopy even if robotic rectal surgery is undoubtedly associated with longer operative times. This review demonstrated that robotic rectal surgery is both safe and feasible but there is no evidence of its superiority over laparoscopy in terms of postoperative, clinical outcomes and incidence of complications. In conclusion robotic rectal surgery seems to overcome some of technical limitations of conventional laparoscopic surgery especially for tumors requiring low and ultralow anterior resections but this technical improvement seems not to provide, until now, any significant clinical advantages to the patients. | Fabio Staderini Caterina Foppa Alessio Minuzzo Benedetta Badii Etleva Qirici Giacomo Trallori Beatrice Mallardi Gabriele Lami Giuseppe Macrì Andrea Bonanomi Siro Bagnoli Giuliano Perigli Fabio Cianchi | 2016 | World Journal of Gastrointestinal Oncology2016，8，11： | 7 |
| 5 | Carbon-Isotope Excursions Recorded in the Cambrian System,South China:Implications for Mass Extinctions and Sea-Level Fluctuations显示文摘Cambrian carbonates with abundant fossils of agnostoid trilobites deposited on the southern slope(Jiangnan slope belt) of the Yangtze Platform and in the Jiangnan deepwater basin are well exposed in the Wangcun Section of western Hunan, South China, and in the Duibian A Section of western Zhejiang, southeastern China, respectively. To better understand the response of carbon-isotope excursions to depositional environment changes, mass extinctions and eustatic events, we collected 530 carbonate samples in fresh roadcut exposures of the two measured sections for analysis of carbon and oxygen isotopic compositions. Data of δ13 C from the Wangcun Section, western Hunan, South China, demonstrate that the Cambrian carbon-isotope profile includes three remarkable positive excursions CPEwc-1, 2, 3 in the Upper Series 2, in the Lower and in the Middle Furongian Series. Three distinctive negative excursions CNEwc-1, 2, 3 were separately tested in the Lower Terreneuvian Series, Lower Series 3 and in the Upper Furongian Series. Similarly, in the corresponding horizons in the Duibian A Section, Zhejiang Province, southeastern China, three positive excursions CPEdb-1, 2, 3 and three negative excursions CNEdb-1, 2, 3 also have been discovered. We interpret these significant carbon-isotope excursions as being associated with enhanced biogenic productivity, mass extinctions and eustatic events. | Jingxun Zuo Shanchi Peng Yuping Qi Xuejian Zhu Gabriella Bagnoli Huaibin Fang | 2018 | Journal of Earth Science2018，29，3： | 6 |
| 6 | Proposed GSSP for the base of Cambrian Stage 9,coinciding with the first appearance of Agnostotes orientalis, at Duibian, Zhejiang, China显示文摘Exposed in natural outcrops near the Duibian Village, Jiangshan County, Zhejiang Province, China, the Duibian B section is proposed as the boundary stratotype for the base of an unnamed stage termed provisionally Cambrian Stage 9. The proposed position of the GSSP is 108.12 m above the base of the Huayansi Formation, at a horizon coinciding with the first appearance of the cosmopolitan agnostoid trilobite Agnostotes orientalis. This horizon coincides also with the first appearance of the cosmopoli-tan polymerid trilobite Irvingella angustilimbata. The section fulfills all the requirements for a GSSP, and the horizon can be constrained not only by the primary stratigraphic marker (A. orientalis) but also with secondary biostratigraphic, chemostratigraphic, and sequence-stratigraphic correlation tools. The first appearance of A. orientalis is one of the most readily recognizable levels in Cambrian, and can be correlated with precision to all paleocontinents. | Loren E. BABCOCK Gabriella BAGNOLI | 2009 | Science China Earth Sciences2009，52，4： | 4 |
| 7 | Cellular FLICE - inhibintory protein ( c - FLIP) signalling: A key regulator of receptor - mediated apoptosis in physiologic context and in cancer显示文摘 | Bagnoli M Canevari S Mezzanzanica D | 2010 | Int J Biochem & Cell Biol2010，42，2： | 1 |
| 8 | The pathophysiology of retinopathy of prematurity: an update of previous and recent knowledge 显示文摘 | Cavallaro G Filippi L Bagnoli P | 2013 | Acta Ophthalmol2013，131，1： | 1 |
| 9 | The pathophysiology of retinopathy of prematurity:an update of previous and recent knowledge显示文摘 | Cavallaro G Filippi L Bagnoli P | | 0，，： | 1 |
| 10 | The response of aluminium/GLARE hybrid materials to impact and to in-plane fatigue显示文摘 | F. Bagnoli M. Bernabei D. Figueroa-Gordon P.E. Irving | 2009 | Materials Science & Engineering A2009，，1： | 1 |
| 11 | Development of an erbium-doped fibre laser as a deep-sea hydrophone显示文摘 | BAGNOLI P E BEVERINI N FALCIAI R | 2006 | Journal of Optics:A2006，8，7： | 1 |
| 12 | The Theory of Fuzzy Logic and Its Application to Real Estate Valuation 显示文摘 | Bagnoli C Smith H C | 1998 | Journal of Real Estate Research1998，16，2： | 1 |
| 13 | On the influence of the backbone conformations of a side chain liquid crystal polymer on the fast rotational dynamics of a probe molecule显示文摘 | Laura A Bagnoli B Massimo F | 2001 | Molecular Crystals and Liquid Crystals2001，372，1： | 1 |
| 14 | Sensitization of p53- mutated epithelial ovarian cancer to CD95-mediated apoptosis is synergistically induced by cisplatin pretreatment显示文摘 | Bagnoli M Balladore E Luison E | 2007 | Mol Cancer Ther2007，6，2： | 1 |
| 15 | Fatigue fracture of a main landing gear swinging lever in a civil aircraft 显示文摘 | BAGNOLI F DOLCE F COLAVITA M | 2008 | Engineering Failure Analysis2008，15，6： | 1 |
| 16 | Morphological and functional changes in the retinotectal system of the pigeon during the early posthatching period显示文摘 | Bagnoli P Fontanesi G Sebastiani L | 1987 | J Comp Neurol1987，256，： | 1 |
| 17 | The urokinase plasminogen activator gene (PLAU) is not associated with late onset Alzheimer's disease显示文摘 | Bagnoli S Tedde A Cellini E | | 0，，： | 1 |
| 18 | The urokinase-plasminogen activator(PLAU) gene is not associated with late onset Alzheimer's disease显示文摘 | Tedde A Cellini E | 2005 | Neurogenetics2005，6，： | 1 |
| 19 | Stock price manipulation through take over bids显示文摘 | Bagnoli M Lipman B | 1996 | Rand Journal of Economics1996，27，1： | 1 |
| 20 | The expres- sion of the estrogen receptor in obese patients with high breast density (HBD) 显示文摘 | Souza MA Fonseca Ade M Bagnoli VR | 2014 | Gynecol Endocrinol2014，30，1： | 1 |
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