|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | Sandwich injection-molding of thermotropic copolyesters and filled polyester 显示文摘 | Baird D G Wilkes G L | 1983 | Polym Eng Sci1983，23，11： | 2 |
| 3 | OxLDL induced cell death is inhibited by the macrophage synthesised pterin,7,8-dihydroneopterin,in U937 cells but not THP-1 cells显示文摘 | BAIRD S K REID L HAMPTON M B | 2005 | Biochem Biophys Acta2005，1745，： | 1 |
| 4 | The use of QSD (q-sequence deconvolution) to recover supeposed,transient evokedresponses显示文摘 | D L Jewett G Caplovitz B Baird | 2004 | Clinical Neurophysiology2004，115，12： | 1 |
| 5 | Thermal and structural studies of flexible and semi rigid polymeric blends 显示文摘 | Joseph E G L Wilkes G Baird D G | 1983 | Polymer1983，24，： | 1 |
| 6 | Monitoring Keap1-Nrf2 interactions in single live cells显示文摘 | Baird L Swift S Lleres D | 2014 | Biotechnol Adv2014，32，6： | 1 |
| 7 | The cytoprotective role of the Keap1-Nrf2 pathway显示文摘 | Baird L Dinkova-Kostova A T | 2011 | Arch Toxicol2011，85，4： | 1 |
| 8 | Genetic linkage mapping in peach using morphological,RFLP and RAPD markers显示文摘 | RAJAPAKSE S BELTHOFF L E HE G ESTAGER A E SCORZA R VERDE I BALLARD R E BAIRD W V CALLAHAN A MONET R ABBOTT A G | 1995 | Theor Appl Genet1995，90，： | 1 |
| 9 | The cytoproteetive role of the Keapl- Nrf2pathway显示文摘 | Baird L Dinkova-Kostova AT | 2011 | Areh Toxicol2011，85，4： | 1 |
| 10 | Trinexapac-ethyl arm ni- trogen effects on creeping bentgrass grown under reduced light conditions 显示文摘 | Goss R M Baird J H Kelm S L | 2002 | Crop Science2002，42，2： | 1 |
| 11 | Construction of a genetic linkage map and identification of AFLP markers for resistance to root-knot nematodes in peach rootstocks显示文摘 | LU Z X SOSINSKI B REIGHARD G L BAIRD W V ABBOTT A G | 1998 | Genome1998，41，： | 1 |
| 12 | Perihematomal edema in primary intracerebral hemorrhage is plasma derived显示文摘 | Butcher KS Baird T MacOregor L | 2004 | Stroke2004，35，8： | 1 |
| 13 | Posterolateral transfibular approach to tibial plateau fractures: technique, results, and rationale显示文摘 | Solomon L B Stevenson A W Baird R P | 2010 | J Orthop Trauma2010，24，8： | 1 |
| 14 | What Characterizes a Productive Re search Department? 显示文摘 | Baird L L | 1986 | Research in Higher Edu cazion1986，25，3： | 1 |
| 15 | Pressure garments for use in the treatment of hypertrophic scars--a review of the problems associated with their use显示文摘 | Macintyre L Baird M | | 0，，01： | 1 |
| 16 | Effects of breed and production system on lameness parameters in dairy cattle显示文摘 | Baird L G O'Connell N E McCoy M A | 2009 | J Dairy Sci2009，92，： | 1 |
| 17 | Minimally disruptive decompression and transforaminal lumbar interbody fusion显示文摘 | Ozgur B M Hughes S A Baird L C | 2006 | Spine J2006，6，1： | 1 |
| 18 | The chilling of carcasses显示文摘 | Savell J W Mueller S L Baird B E | 2005 | Meat Science2005，70，3： | 1 |
| 19 | Maintenance of 3T3-L1cells in culture media containing saturated fatty acids decreases insulin binding and insulin action显示文摘 | GRUNFELD C BAIRD K L KAHN C R | 1981 | Biochem Biophys Res Commun1981，103，1： | 1 |
| 20 | The cytoprotective role of the Keapl-Nrf2 path-way 显示文摘 | Baird L Dinkova-Kostova AT | 2011 | Arch Toxicol2011，85，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员