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| 1 | Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats显示文摘AIM:To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (DENA)-induced hepatic carcinogenesis. METHODS:A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each group.Rats in group 1(control group)received a single intraperitoneal(i.p.)injection of normal saline. Animals in group 2(carnitine-supplemented group) were given L-carnitine(200 mg/kg per day)in drinking water for 8 wk.Animals in group 3(carnitine-depleted group)were given D-carnitine(200 mg/kg per day)and mildronate(200 mg/kg per day)in drinking water for 8 wk.Rats in group 4(DENA group)were injected with a single dose of DENA(200 mg/kg,i.p.)and 2 wk later received a single dose of carbon tetrachloride(2 mL/kg) by gavage as 1:1 dilution in corn oil.Animals in group 5(DENA-carnitine depleted group)received the same treatment as group 3 and group 4.Rats in group 6 (DENA-carnitine supplemented group)received the same treatment as group 2 and group 4.RESULTS:Administration of DENA resulted in a significant increase in alanine transaminase(ALT), gamma-glutamyl transferase(G-GT),alkaline phosphatase(ALP),total bilirubin,thiobarbituric acid reactive substances(TBARS)and total nitrate/ nitrite(NOx)and a significant decrease in reduced glutathione(GSH),glutathione peroxidase(GSHPx), catalase(CAT)and total carnitine content in liver tissues.In the carnitine-depleted rat model,DENA induced a dramatic increase in serum ALT,G-GT,ALP and total bilirubin,as well as a progressive reduction in total carnitine content in liver tissues.Interestingly, L-carnitine supplementation resulted in a complete reversal of the increase in liver enzymes,TBARS and NOx,and a decrease in total carnitine,GSH,GSHPx, and CAT induced by DENA,compared with the control values.Histopathological examination of liver tissues confirmed the biochemical data,where L-carnitine prevented DENA-induced hepatic carcinogenesis while D-carnitine-mildronate aggravated DENA-induced hepatic damage. CONCLUSION:Data from this study suggest for the first time that:(1)carnitine deficiency is a risk factor and should be viewed as a mechanism in DENA- induced hepatic carcinogenesis;(2)oxidative stress plays an important role but is not the only cause of DENA-induced hepatic carcinogenesis;and(3) long-term L-carnitine supplementation prevents the development of DENA-induced liver cancer. | Salim S Al-Rejaie Abdulaziz M Aleisa Abdulaziz A Al-Yahya Saleh A Bakheet Abdulmalik Alsheikh Amal G Fatani Othman A Al-Shabanah Mohamed M Sayed-Ahmed | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 2 | F-18 fluorodeoxyglucose chest uptake in lung inflammation and infection显示文摘 | Bakheet S M Saleem M Powe J | 2000 | Clin Nucl Med2000，25，4： | 1 |
| 3 | F-18 fluorodeox-yglucose chest uptake in lung inflammation and infection显示文摘 | Bakheet S M Saleem M Powel J | 2000 | Clin Nucl Med2000，25，4： | 1 |
| 4 | 123I isotope as a diagnostic agent in the follow-up of patients with differentiated thyroid cancer:comparison with post 131I therapy whole body scanning显示文摘 | ALZAHRANI A S BAKHEET S AL MANDIL M | 2001 | J Clin Endocrinol Metabo2001，86，11： | 1 |
| 5 | An update of AU-rich element mRNA database显示文摘 | Bakheet T Williams B R Khabar K S | 2003 | Nucleic Acids Research2003，31，1： | 1 |
| 6 | Bone mineral density of the spine and femur in healthy saudi pregnancy and lactation显示文摘 | Hammami M M Bakheet S M | 1999 | Calcified Tissue International1999，65，1： | 1 |
| 7 | Benign causes of 18F- FDG uptake on whole body imaging显示文摘 | Bakheet S M Powe J | 1998 | Semin Nucl Med1998，28，4： | 1 |
| 8 | Glutaricaciduria type D : observations in seven patients with neo-natal-and late-onset disease 显示文摘 | al-Essa M A Rashed M S Bakheet S M ei al | 2000 | J Perinatol2000，20，2： | 1 |
| 9 | 99TcZ-human serum al- bumin scans in children with protein-losing enteropathy显示文摘 | Halaby I-I Bakheet SM Shabib S | 2000 | J NuclMed2000，41，： | 1 |
| 10 | 18Fluoro-2-deoxyglucose( 18FDG) PET scan ofthe brain in propionic acidemia: clinical and MRI correlations显示文摘 | Al-Essa M Bakheet S Patay Z | 1999 | Brain Dev1999，21，5： | 1 |
| 11 | Regulation of fat storage and reproduction by Kruppel-like transcription factor KLF3 and fat- associated genes in Caenorhabditis elegans 显示文摘 | Jun Zhang Razan Bakheet Ranjit S | 2011 | J Molecular Biology2011，411，3： | 1 |
| 12 | Effect of dihydrokainate on the capacity of repair of DNA damage and apoptosis induced by doxorubicin显示文摘 | Attia S M Bakheet S A | 2013 | Mutagenesis2013，28，： | 1 |
| 13 | Inhibition of polymer formation in electrochemical degradation of p-nitrophenol by combining electrolysis with ozonation显示文摘 | Bakheet B Qiu C Yuan S | 2014 | Chemical Engineering Journal2014，252，： | 1 |
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