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| 1 | High prevalence of multidrug-resistance in Acinetobacter baumannii and dissemination of carbapenemase-encoding genes bla_(OXA-23-like),bla_(OXA-24-like)and bla_(NDM-1) in Algiers hospitals显示文摘Objective:To assess and characterize antibiotic resistance in Acinetobacter baumannii strains recovered from 5 health-care facilities in Algiers.Methods:Antibiotic susceptibility testing was performed by agar diffusion and agar dilution methods,resistance genes were identified by PCR and sequencing,and molecular typing of isolates was carried out by enterobacterial repetitive intergenic consensus-PCR(ERIC-PCR).Results:Among 125 tested isolates,117(93.6% ) were multidrug-resistant.of which 94(75.2% ) were imipenem resistant.The bla_(ADC)and bla_(OXA-51-like) genes were detected in all isolates,in association with ISAba I sequence in 84% and 8% (imipenem resistant) of isolates,respectively.The bla_(OXA-23-like) and bla_(OXA-24-like)carbapenemase genes were delected in 67.02% and 20.21% of imipenem-resistant isolates,respectively.The bla_(OXA-23-like) gene is linked to ISAba1 or ISAba4 elements.The metallo-β-lactamase NDM-1 gene was found in 10(10.6% ) imipenem-resisianl strains from three hospitals,it is linked to ISAba125 clement in nine strains.Extended spectrum β-lactamases production was not detected.Imipenem and cefotaxime resistance phenolypes could not be transferred to Escherichia coli by conjugation.Outer membrane protein CarO gene was not delected in four imipenem-resisianl isolates.The aac(6')-1b.sul1,sul2,tetA and tetB genes were present in 5.31% .36.17% .77.65% .1.06% and 65.92% of strains,respectively.Class 1 integrons were detected in 23.4% strains.KRIC-PCR typing showed a genetic diversity among bla_(OXA-23-like) and bla_(OXA-24-like) positive strains,while clonality was observed among bla_(NDM-1)positives.Conclusions:This study highlighted the high prevalence of imipenem resistance in Acinetobacter baumannii in Algiers hospitals mediated mainly by bla_(OXA-23-like),bla_(OXA-24-like),and bla_(NDM-1) genes. | Khadidja Khorsi Yamina Messai Moufida Hamidi Houria Ammari Rabah Bakour | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，6： | 20 |
| 2 | Risk factors associated with endometrial polyps in abnormal uterine bleeding显示文摘 | S.H Bakour J.K Gupta K.S Khan | 2002 | International Journal of Gynecology and Obstetrics2002，，2： | 2 |
| 3 | Risk factors associated with endometrial polyps in abnomal uterine bleeding显示文摘 | Bakour SH Gupta JK Khan KS | 2002 | Int Gynaecol Obstet2002，76，2： | 1 |
| 4 | Rapid detection of carbapenem resistance in Acinetobacter baumannii using matrix-assisted laser desorption ionization-time of flight mass spectrometry显示文摘 | KEMPF M BAKOUR S FLAUDROPS C | 2012 | PLoS One2012，7，31： | 1 |
| 5 | The risk of premalignant and malignant pathology in endometrial polyps显示文摘 | Bakour SH Khan KS Gupta JK | 2000 | Acta Obstet Gynecol Scand2000，79，8： | 1 |
| 6 | Ambulatory hysteroscopy:evidence-based guide to diagnosis and therapy显示文摘 | Bakour SH Jones SE O'Donovan P | 2006 | Best Pract Res Clin Obstet Gynaecol2006，20，6： | 1 |
| 7 | The risk of premalignant and malignant pathology in endometrial polyps显示文摘 | Bakour SH Khan KS Gupta JK | 2000 | Acta Obstet Gynecol Scand2000，79，： | 1 |
| 8 | Risk factors associated with endometrial polyps in abnormal uterine bleeding 显示文摘 | Bakour SH Gupta JK Khan KS | 2002 | lnt ] Gynaecol Obstet2002，76，： | 1 |
| 9 | BRCA1 and BRCA2 germline mutations screening in algerian breast/ovarian cancer families显示文摘 | Cherbal F Bakour R Adane S | 2010 | Disease Markers2010，28，6： | 1 |
| 10 | The risk of premalighantand malignant pathology in endometrial polyps显示文摘 | Bakour SH Rhan RS Gupta JK | 2000 | Acta ObstetGy-necolScand2000，79，1： | 1 |
| 11 | Risk factors associated with endometrial polyps in abnormal uterine bleeding显示文摘 | Bakour SH Gupta JK Khan KS | 2002 | Int J Gynaecol Obstet2002，76，： | 1 |
| 12 | The differential expression of oestrogen receptors,progesterone receptors,Bcl-2and Ki67 in endometrial polyps显示文摘 | BAKOUR L J JACKSON T L REID J G | 2003 | BJOG2003，110，9： | 1 |
| 13 | Risk factors associated with endometrial polyps in abnormal uterine bleeding显示文摘 | Bakour SH Gupta JK Khan KS | 2002 | Int J Gynaecol Obstet2002，76，2： | 1 |
| 14 | The risk of premalignant and malignant pathology in endometriai polyps显示文摘 | Khan KS Gupta JK | 2002 | Acta Obstet Gynecol Scand2002，81，2： | 1 |
| 15 | The risk of premalignant and ma- lignant pathology in endomtrial polyps 显示文摘 | Bakour SH Khan KS Gupta JK | 2002 | Acta Obstet Gynecol scand2002，81，2： | 1 |
| 16 | Ambulatory hysteroscopy: evidence -based guide to diagnosis and theapy 显示文摘 | Bakour SH Jones SE O'Donovan P | 2006 | Best Praet Res Clin Obstet Gynaecol2006，20，6： | 1 |
| 17 | Risk factors associated with endometrial polyps in abnormal uterine bleeding 显示文摘 | Bakour SH Gup ta JK Khan KS | 2002 | Int J Gynaecol Obstet2002，76，2： | 1 |
| 18 | The risk of premalignant and malignant pathoogy in endometrial pollyps显示文摘 | Bakour SH Khan KS Gupta JK | 2000 | Acta Obstet Gynecol Scand2000，79，： | 1 |
| 19 | The risk of premalignant and malignant pathology in endometrial polyps显示文摘 | Bakour SH Khan KS Gupta JK | 2000 | Acta Obstet Gynecol Scand2000，79，： | 1 |
| 20 | The risk of premalignant and malignant pathology in endometrial polyPs显示文摘 | Bakour SH Khan KS Gupta JK | 2000 | Acta Obstet Gynecol Scsand2000，79，： | 1 |
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