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| 1 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 2 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 3 | Benchmarking quality systems in two European academic libraries 显示文摘 | Balagu N Saarti J | 2009 | Library Manage- ment2009，30，45： | 1 |
| 4 | Understanding autoimmune disease:new targets for drug discovery显示文摘 | Balagué C Kunkel SL Godessart N | | 0，，19： | 1 |
| 5 | Identification of Lynch syndrome among patients with colorectal cancer显示文摘 | Moreira L Balaguer F Lindor N | 2012 | JAMA2012，308，15： | 1 |
| 6 | In situ hybridization shows distinct patterns of mucin gene expression normal, benign, and malignant pancreas tissues显示文摘 | Balague C Audie JP Porchet N | 1995 | Gastroenterology1995，109，： | 1 |
| 7 | AhR-and NF-κ B-dependent induction of interlenkin-6 by co-exposure to the environmental contaminant benzanthracene and the cytokine tumor necrosis factor-α in human mammary MCF-7 cells 显示文摘 | KOLASA E HOULBERT N BALAGUER P | 2013 | Chem Biol Interact2013，203，2： | 1 |
| 8 | In situ hybridization shows distinct patterns of mucin gene expression in normal,benign,and malignant pancreas tissues显示文摘 | Balagué C Audié JP Porchet N | 1995 | Gastroenterology1995，109，： | 1 |
| 9 | Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line显示文摘 | Laville N Balaguer P Brion F | 2006 | Toxicology2006，，： | 1 |
| 10 | Understanding autoimmune disease:new targets for drug discovery显示文摘 | Balagué C Kunkel SL Godessart N | 2009 | Drug Discov Today2009，14，1920： | 1 |
| 11 | Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line显示文摘 | LAVILLE N BALAGUER P BRION F | 2006 | Toxicol2006，228，1： | 1 |
| 12 | Quality audits as a tool for quality improvement in selected european higher education libraries显示文摘 | Balague N Duren P Juntunen A | 2014 | Journal of Academic Librarianship2014，40，5： | 1 |
| 13 | Evaluation of an hPXRreporter gene assay for the detection of aquatic emerging pollu-tants:screening of chemicals and application to water samples显示文摘 | Creusot N Kinani S Balaguer Pi | 2010 | Analitical and Bioanalitical Chemistry2010，396，2： | 1 |
| 14 | ln situ hybridization shows distinct patters of mucin gene expression in normal,benign,and malignant pancreas tissues显示文摘 | Balague C Audie IP Prochet N | 1995 | Gastroenterology1995，109，： | 1 |
| 15 | Evaluation of an hPXR reporter gene assay for the detection of aquatic emerging pollutants: Screening of chemicals and application to water samples 显示文摘 | Creusot N Kinani S Balaguer P | 2010 | Anal Bioanal Chem2010，396，2： | 1 |
| 16 | Plastic surgery improves long-term weight control after bariatric surgery显示文摘 | Balague N Combescure C Huber O | 2013 | Plast Reconstr Surg2013，132，4： | 1 |
| 17 | Understanding autoimmune disease: new targets for drug discovery显示文摘 | Balague C Kunkel SL Godessart N | 2009 | Drug Discovery Today2009，14，19： | 1 |
| 18 | Hydalid disease of the femoral shaft treated with surgery and hypertonic solution wash-out combined with albendazole显示文摘 | Jacquot N Balaguer T de Peretti F | 2005 | Rev Chit Orthop Reparatrice Appar Mot2005，91，6： | 1 |
| 19 | Application of a solid tumor model to evaluate tumor recurrence after an open or laparoscopic rectal resection in rats显示文摘 | Braumann C Balague C Guenther N | 2008 | Surg Laparosc Endosc Percutan Tech2008，18，4： | 1 |
| 20 | Third degree formic acid chemical burn in the trealmen! of a hand wart: a case re- port and review of the literature显示文摘 | Balague N Vostrel P Beaulieu JY | 2014 | Springer Plus2014，3，： | 1 |
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