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| 1 | Genotypic Characterization of Methicillin-resistant Staphylococcus aureus Isolated from Pigs and Retail Foods in China显示文摘Objective To investigate the genotypic diversity of Methicillin-resistant Staphylococcus aureus(MRSA) isolated from pigs and retail foods from different geographical areas in China and further to study the routes and rates of transmission of this pathogen from animals to food. Methods Seventy-one MRSA isolates were obtained from pigs and retail foods and then characterized by multi-locus sequencing typing(MLST), spa typing, multiple-locus variable number of tandem repeat analysis(MLVA), pulsed-field gel electrophoresis(PFGE), and antimicrobial susceptibility testing. Results All isolated MRSA exhibited multi-drug resistance(MDR). Greater diversity was found in food-associated MRSA(7 STs, 8 spa types, and 10 MLVA patterns) compared to pig-associated MRSA(3 STs, 1 spa type, and 6 MLVA patterns). PFGE patterns were more diverse for pig-associated MRSA than those of food-associated isolates(40 vs. 11 pulse types). Among the pig-associated isolates, CC9-ST9-t899-MC2236 was the most prevalent clone(96.4%), and CC9-ST9-t437-MC621(20.0%) was the predominant clone among the food-associated isolates. The CC9-ST9 isolates showed significantly higher antimicrobial resistance than other clones. Interestingly, CC398-ST398-t034 clone was identified from both pig-and food-associated isolates. Of note, some community-and hospital-associated MRSA strains(t030, t172, t1244, and t4549) were also identified as food-associated isolates. Conclusion CC9-ST9-t899-MC2236-MDR was the most predominant clone in pigs, but significant genetic diversity was observed in food-associated MRSA. Our results demonstrate the great need for improved surveillance of MRSA in livestock and food and effective prevention strategies to limit MDR-MRSA infections in China. | WANG Wei LIU Feng ZULQARNAIN Baloch ZHANG Cun Shan MA Ke PENG Zi Xin YAN Shao Fei HU Yu Jie GAN Xin DONG Yin Ping BAI Yao LI Feng Qin YAN Xiao Mei MA Ai Guo XU Jin | 2017 | Biomedical and Environmental Sciences2017，30，8： | 13 |
| 2 | The Ability of Baseline Triglycerides and Total Cholesterol Concentrations to Predict Incidence of Type 2 Diabetes Mellitus in Chinese Men and Women:A Longitudinal Study in Qingdao, China显示文摘Objectives The purpose of this study was to assess the association between triglycerides(TG),total cholesterol(TC)at baseline,and type 2 diabetes mellitus(T2DM)incidence in a general Chinese population.Further,it aimed to evaluate the ability of TG and TC to predict T2DM incidence.Methods Qingdao Diabetes Prevention Program participants recruited between 2006 and 2009 were followed up in 2012–2015.TG,TC,and T2DM status were measured.Cox proportional hazards models were used to estimate the association between TG,TC,and T2DM incidence.The receiver operating characteristic(ROC)curve was used to evaluate the ability of TG and TC to identify T2DM participants.Results The incidence of T2DM significantly increased with TG in women and TC in both men and women(Ptrend<0.05).Univariate Cox regression indicated that higher TG{borderline high TG[hazards ratio(HR):2.05;95%confidence interval(CI):1.40,3.00]and hypertriglyceridemia[HR:2.64;95%CI:1.68,4.15]}and TC[hypercholesterolemia(HR:2.05;95%CI:1.43,2.95)]were significantly associated with increased risk of T2DM incidence in women but not in men.Multivariate Cox regression showed that hypertriglyceridemia in women(HR:1.78,95%CI:1.07,2.97),borderline high TC in men(HR:1.61,95%CI:1.04,2.48),and hypercholesterolemia in women(HR:1.68,95%CI:1.81,2.61)had a higher significant risk of T2DM incidence.The optimal cutoff values of TG were>1.15 and>1.23 mmol/L in men and women,respectively.For TC,they were>5.17 and>5.77 mmol/L in men and women,respectively.The area under the ROCs of TG and TC were 0.54(0.51–0.57)and 0.55(0.52–0.58),respectively,in men,and 0.60(0.58–0.62)and 0.59(0.56–0.61),respectively,in women.Conclusion Elevated TG and TC were risk factors for T2DM incidence.However,no predictive capacity was found for both factors to identify T2DM incidence in Chinese men and women.Hence,TG and TC levels in both Chinese men and women might be used for decreasing the incidence of T2DM but no clinical predictive capacity for T2DM. | CUI Jing MA Ping SUN Jian Ping Zulqamain Baloch YIN Fan XIN Hua Lei REN Jie TAN Ji Bin WANG Bing Ling | 2019 | Biomedical and Environmental Sciences2019，32，12： | 7 |
| 3 | Topiramate induced sudden loss of vision显示文摘 | Baloch M Siddiqui MA | 2012 | J Pak Med Assoc2012，62，10： | 1 |
| 4 | Angioembolization in itractable epistaxis-a tertiary care experience显示文摘 | Baloch MA Awan MS Resident HN | 2012 | J Pak Med Assoc2012，62，3： | 1 |
| 5 | Topiramate induced sudden loss of vision显示文摘 | Baloch M Siddiqui MA | 2012 | J Pak Med Assoc2012，62，10： | 1 |
| 6 | COVID-19 impact on high school student’s education and mental health:A cohort survey in China显示文摘BACKGROUND The ongoing coronavirus disease 2019(COVID-19)pandemic and the universal implementation of control measures are fundamentally affecting every aspect of our society and daily lives.AIM To evaluate the prevalence of post-traumatic stress disorder symptoms and their associated factors as well as the effects and attitudes towards online education in Chinese high school students.METHODS A total of 883 students were included.The first,second and third-year students of a high school in Lanzhou,Gansu province of China were invited to participate in this study.They were requested to involve their parents to complete the survey together.A detailed questionnaire of 65 questions was designed and divided into five sections.The survey was anonymously conducted via WeChat,a Chinese multipurpose messaging,social media and mobile payment app.RESULTS Overall,32.94%of students experienced post-traumatic stress disorder due to the COVID-19 epidemic.The majority of students(60.82%)felt that online education was not(10.76%)or less effective(50.06%)in terms of gaining knowledge and improving practical and communications skills.Correlation analysis revealed that the class level,residential background and whether living with parents were significantly linked with the effectiveness and satisfaction of the online education system.Of the final year students,74.2%said that the COVID-19 outbreak has negatively affected their preparation for the college entrance exam,and 68%of students felt that this outbreak increased psychological pressure for their college entrance examination preparation.In case of having COVID-19 symptoms during the exam,50.7%,13.3%,and 10.2%would notify the proctor,teacher and parents,respectively.CONCLUSION We found a high prevalence rate of post-traumatic stress disorder symptoms in high school students.Thus,our results call for urgent attention from both government and schools to implement effective interventions to cope with the psychological effects and the disturbance of education by COVID-19 on children. | Zhong-Ren Ma Wei-Hua Ma Sakinah Idris Qiu-Wei Pan Zulqarnain Baloch | 2021 | World Journal of Psychiatry2021，11，6： | 0 |
| 7 | COVID-19 knowledge,risk perception,and information sources among Chinese population显示文摘BACKGROUND Measures for effective control of the coronavirus disease 2019(COVID-19)pandemic include identifying the causal organisms,applying appropriate therapies,and developing vaccines,as well as improving understanding among the general public.AIM To evaluate the knowledge,awareness,perception,and response of the general public to COVID-19 in China.METHODS A detailed questionnaire comprising 47 questions designed in both English and Chinese was developed.The survey was conducted via WeChat,a multipurpose messaging,social media,and mobile payment app that is widely used by the Chinese population.In total,1006 participants responded,and most of them were from different provinces of China's Mainland.RESULTS Overall,this comprehensive survey revealed that the general public in China is highly aware of the basic information concerning COVID-19 and its precautions.Interestingly,more respondents(99.3%)were aware of the term severe acute respiratory syndrome(SARS)than COVID-19(97.2%)and Middle East respiratory syndrome(MERS)(73.4%).Among them,2.4%,1.6%,and 0.9%said that they or their family members or friends were affected by COVID-19,SARS,and MERS,respectively.The majority of the respondents(91.2%)indicated that knowledge about COVID-19 was received mainly from WeChat,followed by TV(89%),friends(76.1%),and QQ(a Chinese instant messaging software service)(57.7%).CONCLUSION The general public in China is highly aware of COVID-19 and the necessary precautions.Unexpectedly,2.8%of the participants were unaware of the current epidemic.The remaining information gaps highlight the necessity of further enhancing awareness and preparedness. | Zhong-Ren Ma Sakinah Idris Qiu-Wei Pan Zulqarnain Baloch | 2021 | World Journal of Psychiatry2021，11，5： | 0 |
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