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| 1 | Innate immunity in tuberculosis: host defense vs pathogen evasion显示文摘The major innate immune cell types involved in tuberculosis(TB)infection are macrophages,dendritic cells(DCs),neutrophils and natural killer(NK)cells.These immune cells recognize the TB-causing pathogen Mycobacterium tuberculosis(Mtb)through various pattern recognition receptors(PRRs),including but not limited to Toll-like receptors(TLRs),Nod-like receptors(NLRs)and C-type lectin receptors(CLRs).Upon infection by Mtb,the host orchestrates multiple signaling cascades via the PRRs to launch a variety of innate immune defense functions such as phagocytosis,autophagy,apoptosis and inflammasome activation.In contrast,Mtb utilizes numerous exquisite strategies to evade or circumvent host innate immunity.Here we discuss recent research on major host innate immune cells,PRR signaling,and the cellular functions involved in Mtb infection,with a specific focus on the host’s innate immune defense and Mtb immune evasion.A better understanding of the molecular mechanisms underlying host–pathogen interactions could provide a rational basis for the development of effective anti-TB therapeutics. | Cui Hua Liu Haiying Liu Baoxue Ge | 2017 | Cellular & Molecular Immunology2017，14，12： | 43 |
| 2 | High doses of α-galactosylceramide potentiate experimental autoimmune encephalomyelitis by directly enhancing Th17 response显示文摘伪 - Galactosylceramide (伪 - GC ) 广泛地被知道激活不变的自然漂亮 T (iNKT ) 压制髓磷脂的房间抗原特定的 Th1 回答,保护易受影响的老鼠免于试验性的自体免疫的脑脊髓炎(EAE ) 。这里,我们表明那高加重,而非改善的伪 - GC 开 EAE 的意外发现。当与高剂量的伪 - GC 对待的 MOG35-55-specific T 房间被变成 na 时,类似的结果被观察 ? ve syngeneic 接受者老鼠。进一步的学习证明伪 - GC 的高剂量直接通过 STAT3 的 phosphorylation 和 NF-魏 B 的激活由 CD4+CD44+ 记忆 T 房间的激活提高 Th17 和 Th1 反应。不同于由伪 - GC 的低剂量的 iNKT 房间的激活,伪 - GC 的高剂量直接交往了, CD1d 在 T 房间上表示了并且激活 Th17 和 Th1 房间。而且,介绍抗原的房间(APC ) 主要表示 CD1d1,而 CD4+ T 房间快车 CD1d2 的多数。由 RNAi 的 CD1d1 或 CD1d2 基因表示击倒分别地防碍 iNKT 或 Th17/Th1 房间的激活。因此,伪 - GC 处理能改善或变得更坏由雇佣取决于剂量的 APC 或 Th17/Th1 房间的 EAE 使用了。 | Gaochao Qian Xia Qin Ying Qin Zang Baoxue Ge Taylor B Guo Bing Wan Lei Fang Jingwu Z Zhang | 2010 | Cell Research2010，20，4： | 3 |
| 3 | Charge recombination in dye-sensitized nanoporous TiO_(2)solar cell显示文摘DSSC has been a subject of intense study throughout the world. The efforts to investigate DSSC are mainly focused on how to increase light absorption, speed electron transport in circuit and reduce charge recombina-tion. In this article, the development of charge recombination in DSSC is discussed, and the investigating techniques, main paths, mechanism and main inhibiting methods of charge recombination in DSSC are also described. | ZHANG Zhe ZHOU Baoxue GE Weijie XIONG Bitao ZHENG Qing CAI Weimin | 2005 | Chinese Science Bulletin2005，50，21： | 3 |
| 4 | Caenorhabditis elegans mom-4 is required for the activation of the p38 MAPK signaling pathway in the response to Pseudomonas aeruginosa infection显示文摘The p38 mitogen-activated protein kinase(MAPK)plays an evolutionarily conserved role in the cellular re-sponse to microbial infection and environmental stress.Activation of p38 is mediated through phosphorylation by upstream MAPKK,which in turn is activated by MAPKKK.In the Caenorhabditis elegans,the p38 MAPK(also called PMK-1)signaling pathway has been shown to be required in its resistance to bacterial infection.However,how different upstream MAP2Ks and MAP3Ks specifically contribute to the activation of PMK-1 in response to bacterial infection still is not clearly un-derstood.By using double-stranded RNA-mediated interference(RNAi)and genetic mutants of C.elegans,we demonstrate that C.elegans MOM-4,a mammalian TAK1 homolog,is required for the resistance of C.elegans to a P.aeruginosa infection.We have also found that the MKK-4 of C.elegans is required for P.aeruginosa resistance,but not through the regulation of DLK-1.In summary,our results indicate that different upstream MAPKKKs or MAPKKs regulate the activation of PMK-1 in response to P.aeruginosa. | Ajing Xu Guojun Shi Feng Liu Baoxue Ge | 2013 | Protein & Cell2013，4，1： | 3 |
| 5 | Modulation of host signaling in the inflammatory response by enteropathogenic Escherichia coli virulence proteins显示文摘为了成功地感染,招待房间并且躲避主机免疫者反应,一个类型 III 分泌物系统(T3SS ) 被伤寒通常使用细菌的病原体象 enteropathogenic Escherichia coli (EPEC ) 那样。最近的调查结果表明了各种各样的受动器通过 T3SS 被注入主人房间并且在煽动性的发信号的小径上施加禁止的效果,破坏对这些病原体的有免疫力的回答。这里,我们考察针对探讨 EPEC 受动器蛋白质调制的几条重要煽动性的发信号小径的调整的最近的研究,例如原子 factor-B ( NF-B )和 激活mitogen 的蛋白质 kinase ( MAPK )小径,它在这块未经勘探的地和帮助里提供卓见进未完成的工作为 EPEC 受动器在煽动性的发信号的网络识别新奇位置。 | Xiaonan Zhuang Zijuan Chen Chenxi He Lin Wang Ruixue Zhou Dapeng Yan Baoxue Ge | 2017 | Cellular & Molecular Immunology2017，14，3： | 1 |
| 6 | Enteropathogenic Escherichia coli Tir recruits cellular SHP-2 through ITIM motifs to suppress host immune response显示文摘 | Dapeng Yan Heming Quan Lin Wang Feng Liu Haipeng Liu Jianxia Chen Xuetao Cao Baoxue Ge | 2013 | Cellular Signalling2013，，9： | 1 |
| 7 | Optimization of Cry3A yields in Bacillus thuringiensis by use of sporulation-dependent promoters in combination with the STAB-SD mRNA sequence显示文摘 | PARK H W GE Baoxue BAUER L S | 1998 | Applied and Environmental Microbiology1998，64，10： | 1 |
| 8 | The multifaceted functions of cGAS显示文摘Pattern recognition receptors arecritical forthe sensing of pathogen-associated molecular patterns or danger-associated molecular patterns and subsequent mounting of innate immunityandshaping ofadaptive immunity.The identification of 2'3'-cyclic guanosine monophosphate-adenosine monophosphate(cGAMP)synthase(cGAS)as a major cytosolic DNA receptor is a milestone in the field of DNA sensing.The engagement of cGAS by double-stranded DNA from different origins,including invading pathogens,damaged mitochondria,ruptured micronuclei,and genomic DNA results in the generation of cGAMP and activation of stimulator of interferon genes,which thereby activates innate immunity mainly characterized by the activation of type I interferon response.In recent years,great progress has been made in understanding the subcellular localization and novel functions of cGAS.In this review,we particularlyfocus on summarizingthe multifaceted roles ofcGAS in regulating senescence,autophagy,cell stemness,apoptosis,angiogenesis,cell proliferation,antitumor effect,DNA replication,DNA damage repair,micronucleophagy,as well as cell metabolism. | Haipeng Liu Fei Wang Yajuan Cao Yifang Dang Baoxue Ge | 2022 | Journal of Molecular Cell Biology2022，14，5： | 0 |
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