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| 1 | Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies显示文摘In the past century, there have been many attempts to treat cancer with low levels of electric and magnetic fields. We have developed noninvasive biofeedback examination devices and techniques and discovered that patients with the same tumor type exhibit biofeedback responses to the same, precise frequencies. Intrabuccal administration of 27.12 MHz radiofrequency(RF) electromagnetic fields(EMF), which are amplitude-modulated at tumor-specific frequencies, results in long-term objective responses in patients with cancer and is not associated with any significant adverse effects. Intrabuccal administration allows for therapeutic delivery of very low and safe levels of EMF throughout the body as exemplified by responses observed in the femur, liver, adrenal glands, and lungs. In vitro studies have demonstrated that tumor-specific frequencies identified in patients with various forms of cancer are capable of blocking the growth of tumor cells in a tissue- and tumor-specific fashion. Current experimental evidence suggests that tumor-specific modulation frequencies regulate the expression of genes involved in migration and invasion and disrupt the mitotic spindle. This novel targeted treatment approach is emerging as an appealing therapeutic option for patients with advanced cancer given its excellent tolerability. Dissection of the molecular mechanisms accounting for the anti-cancer effects of tumor-specific modulation frequencies is likely to lead to the discovery of novel pathways in cancer. | Jacquelyn W.Zimmerman Hugo Jimenez Michael J.Pennison Ivan Brezovich Desiree Morgan Albert Mudry Frederico P.Costa Alexandre Barbault Boris Pasche | 2013 | Chinese Journal of Cancer2013，32，11： | 3 |
| 2 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 3 | Receptor and ligand based 3D-QSAR study for a series of non-nucleoside HIV-1 reverse transcriptase inhibitors 显示文摘 | Rongjing Hu Florent Barbault Michel Delamar | 2009 | Bioorganie & Medicinal Chemistry2009，17，6： | 1 |
| 4 | Solution structure of Alo-3: a new knottin-type antifungal peptide from the insect Acrocinus longimanus显示文摘 | Barbault F Landon C Guenneugues M Meyer JP Schott V Dimarcq JL Vovelle E 2003 | 2003 | Biochemistry2003，42，14： | 1 |
| 5 | Richness and composition of Oasis bird communities:spatial issues and species-area rela-tionships显示文摘 | Selmi S Boulinier T Barbault R | 2002 | The Auk2002，119，2： | 1 |
| 6 | Mycorrhizas and seedling growth of slow-growing sclerophylls from nutrient-poor environments 显示文摘 | Barbault R Doucet MC | 1993 | Journal of Ecology1993，14，： | 1 |
| 7 | Reintroduction, challenges and lessons for basic ecology显示文摘 | SARRAZIN F BARBAULT R | 1996 | Trends in Ecology & Evolution1996，11，11： | 1 |
| 8 | Mycorrhizas and seedling growth of slow-growing sclerophylls from nutrient-lx)or environments显示文摘 | BARBAULT R DOUCET M C | 1993 | Acta Oecol1993，14，： | 1 |
| 9 | Biodiversity dynamics: from population and community ecology approaches to a landscape ecology point of view 显示文摘 | Robert Barbault | 1995 | Landscape and Urban Planning1995，，31： | 1 |
| 10 | The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species 显示文摘 | Ozawa M Barbault H Kemler R | 1989 | EMBO J1989，8，： | 1 |
| 11 | Cellular interaction through LewisX cluster: theoretical studies显示文摘 | Luo Y Barbault F Gourmala C | 2008 | J Mol Model2008，14，10： | 1 |
| 12 | Molecular modeling studies of N-substituted pyrrole derivatives-Potential HIV-1 gp41 inhibitors显示文摘 | Teixeira C Barbault F Rebehmed J | | 0，，： | 1 |
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