|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Respiratory syncytial virus, pneumonia virus of mice, and influenza A virus differently affect respiratory allergy in mice 显示文摘 | Barends M de Rond LG Dormans J | 2004 | Clin Exp Allergy2004，34，3： | 1 |
| 3 | Timing of infection and prior immunization with respiratory syncytial virus (RSV) in RSVenhanced allergic inflammation显示文摘 | Barends M van Oosten M de Rond GH | 2004 | Infect Dis2004，189，： | 1 |
| 4 | Risk analysis of analytical vali- dations by probabilistic modification of FMEA显示文摘 | BARENDS D M OLDENHOF M T VREDEN- BREGT M J | 2012 | Journal of Pharmaceutical and Biomedical Analy- sis2012，6465，： | 1 |
| 5 | Effect of lack of Inter- 1 eukin-4, Interleu-kin-12, Interleukin-18, or the Interferongamma receptor on virus replication,eytokine response, and lung pathology during respiratory syncytial virus infection in mice显示文摘 | Boelen A Kwakkel J Barends M | 2002 | J Med Virol2002，66，： | 1 |
| 6 | Equivalence testing of salbutamol dry powder inhalers: in vitro impaction results versus in vivo efficacy显示文摘 | M Weda P Zanen A.H de Boer D Gjaltema A Ajaoud D.M Barends H.W Frijlink | 2002 | International Journal of Pharmaceutics2002，，1： | 1 |
| 7 | Word sense disambiguation in the biomedical domain:an overview显示文摘 | Martijn J Jan A Barend M | 2005 | Journal of Computational Biology2005，12，5： | 1 |
| 8 | Analysis of body water compartments inrelation to tissue depletion in clinically stable patients with chronic obstructive pulmonary disease显示文摘 | Barends E M Schol A M W J Lichtenbeh WDW | 1997 | Am J Chn Nutr1997，65，： | 1 |
| 9 | Structure and mech-anistic implications of a tryptophan synthase quinonoid inter-mediate显示文摘 | Barends T R M Domratcheva T Kulik V | | 0，，07： | 1 |
| 10 | Transfer -- messenger RNA controls the translation of cell-cycle and stress proteins in Streptomyces 显示文摘 | Barends S Zehl M Bialek S | 2010 | EMBO Rep2010，11，2： | 1 |
| 11 | A different outlook on the role of bone marrow stem cells in vascular growth bone marrow delivers software not hardware显示文摘 | Matthias H Tibor Z Barend M | 2004 | Circulation Research2004，94，： | 1 |
| 12 | Effect of lack of interleukin-4,interleukin-12,interleukin-18,or the interferon-gamma receptor on virus replication,cytokine response,and lung pathology during respiratory syncytial virus infection in mice显示文摘 | Boelen A Kwakkel J Barends M | | 0，，06： | 1 |
| 13 | Patient experiences with the performance of tablet score lines needed for dosing 显示文摘 | RODENHUIS N DE SMET P A BARENDS D M | 2003 | Pharm World Sci2003，25，4： | 1 |
| 14 | A different outlook on the role of bone marrow stem cells in vascular growth:bone marrow delivers software not hardware显示文摘 | Matthias H Tibor Z Barend M | 2004 | Circulation Research2004，94，9： | 1 |
| 15 | Three-dimensional structures of enzymes useful for P-lactam antibiotic production显示文摘 | Thomas R M Barends H Y Bauke W D | 2004 | Current Opinion in Biotechnology2004，15，： | 1 |
| 16 | Becoming an evi- dence-based HR Practitioner 显示文摘 | Denise M Rousseau Eric G R Barends | 2010 | Human Resource Manage- ment Journal2010，2，3： | 1 |
| 17 | Respiratory syncytial virus rnhances respiratory allergy in mice despite the inhibitory effect of virus-induced interferon-gamma显示文摘 | Barends M Boelen A De Rond L | 2003 | J Med Virol2003，69，1： | 1 |
| 18 | Timing of infection and prior immunization with respiratory syncytial virus(RSV) in RSV enhanced allergic inflammation显示文摘 | Barends M Van Oosten M De Rond C G | 2004 | J Infect Dis2004，189，： | 1 |
| 19 | Respiratory syncytial virus enhances respiratory allergy in mice despite the inhibitory effect of virus- induced interferon- 显示文摘 | BARENDS M BOELEN A de ROND L | 2003 | J Med Virol2003，69，1： | 1 |
| 20 | Timing of infection and prior immunization with respiratory syncytial virus (RSV) in RSV-enhanced allergic inflammation显示文摘 | Barends M Van Oosten M De Rond CGH | 2004 | J Infection Dis2004，189，15： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员