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| 1 | A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes显示文摘AIM:To investigate the effectiveness of antioxidant compounds in modulating mitochondrial oxidative alterations and lipids accumulation in fatty hepatocytes.METHODS:Silybin-phospholipid complex containing vitamin E(Realsil) was daily administered by gavage(one pouch diluted in 3 mL of water and containing 15 mg vitamin E and 47 mg silybin complexed with phospholipids) to rats fed a choline-deprived(CD) or a high fat diet [20% fat,containing 71% total calories as fat,11% as carbohydrate,and 18% as protein,high fat diet(HFD)] for 30 d and 60 d,respectively.The control group was fed a normal semi-purified diet containing adequate levels of choline(35% total calories as fat,47% as carbohydrate,and 18% as protein).Circulating and hepatic redox active and nitrogen regulating molecules(thioredoxin,glutathione,glutathione peroxidase),NO metabolites(nitrosothiols,nitrotyrosine),lipid peroxides [malondialdehyde-thiobarbituric(MDA-TBA)],and pro-inflammatory keratins(K-18) were measured on days 0,7,14,30,and 60.Mitochondrial respiratory chain proteins and the extent of hepatic fatty infiltration were evaluated.RESULTS:Both diet regimens produced liver steatosis(50% and 25% of liver slices with CD and HFD,respectively) with no signs of necro-inflammation:fat infiltration ranged from large droplets at day 14 to disseminated and confluent vacuoles resulting in microvesicular steatosis at day 30(CD) and day 60(HFD).In plasma,thioredoxin and nitrosothiols were not significantly changed,while MDA-TBA,nitrotyrosine(from 6 ± 1 nmol/L to 14 ± 3 nmol/L day 30 CD,P < 0.001,and 12 ± 2 nmol/L day 60 HFD,P < 0.001),and K-18(from 198 ± 20 to 289 ± 21 U/L day 30 CD,P < 0.001,and 242 ± 23 U/L day 60 HFD,P < 0.001) levels increased significantly with ongoing steatosis.In the liver,glutathione was decreased(from 34.0 ± 1.3 to 25.3 ± 1.2 nmol/mg prot day 30 CD,P < 0.001,and 22.4 ± 2.4 nmol/mg prot day 60 HFD,P < 0.001),while thioredoxin and glutathione peroxidase were initially increased and then decreased.Nitrosothiols were constantly increased.MDA-TBA levels were five-fold increased from 9.1 ± 1.2 nmol/g to 75.6 ± 5.4 nmol/g on day 30,P < 0.001(CD) and doubled with HFD on day 60.Realsil administration significantly lowered the extent of fat infiltration,maintained liver glutathione levels during the first half period,and halved its decrease during the second half.Also,Realsil modulated thioredoxin changes and the production of NO derivatives and significantly lowered MDA-TBA levels both in liver(from 73.6 ± 5.4 to 57.2 ± 6.3 nmol/g day 30 CD,P < 0.01 and from 27.3 ± 2.1 nmol/g to 20.5 ± 2.2 nmol/g day 60 HFD,P < 0.01) and in plasma.Changes in mitochondrial respiratory complexes were also attenuated by Realsil in HFD rats with a major protective effect on Complex Ⅱ subunit CII-30.CONCLUSION:Realsil administration effectively contrasts hepatocyte fat deposition,NO derivatives formation,and mitochondrial alterations,allowing the liver to maintain a better glutathione and thioredoxin antioxidant activity. | Ignazio Grattagliano Catia V Diogo Maria Mastrodonato Ornella de Bari Michele Persichella David QH Wang Adriana Liquori Domenico Ferri Maria Rosaria Carratù Paulo J Oliveira Piero Portincasa | 2013 | World Journal of Gastroenterology2013，19，20： | 6 |
| 2 | Role of artificial intelligence in hepatobiliary and pancreatic surgery显示文摘Over the past decade,enhanced preoperative imaging and visualization,improved delineation of the complex anatomical structures of the liver and pancreas,and intra-operative technological advances have helped deliver the liver and pancreatic surgery with increased safety and better postoperative outcomes.Artificial intelligence(AI)has a major role to play in 3D visualization,virtual simulation,augmented reality that helps in the training of surgeons and the future delivery of conventional,laparoscopic,and robotic hepatobiliary and pancreatic(HPB)surgery;artificial neural networks and machine learning has the potential to revolutionize individualized patient care during the preoperative imaging,and postoperative surveillance.In this paper,we reviewed the existing evidence and outlined the potential for applying AI in the perioperative care of patients undergoing HPB surgery. | Hassaan Bari Sharan Wadhwani Bobby V M Dasari | 2021 | World Journal of Gastrointestinal Surgery2021，13，1： | 4 |
| 3 | Catalytic decomposition of NEO over the bed material from circulat- ing fluidized bed (CFB) boilers burning biomass fuels and wastes 显示文摘 | Bari~ic V Neyestanaki A K Klingstedt F | 2004 | Energy & fuels2004，18，6： | 1 |
| 4 | Automated network selection in a heterogeneous wireless network environment显示文摘 | BARI F LEUNG V C M | 2007 | IEEE Network2007，21，1： | 1 |
| 5 | Effect of processing on the microstructural properties of water-in-cocoa butter emulsions显示文摘 | DI BARI V NORTON JE NORTON IT | 2014 | J Food Eng2014，122，： | 1 |
| 6 | Accuracy of magnetic resonance imaging in the kee显示文摘 | Bari V Murad M | 2003 | J Coll Physicians Surg Pak2003，13，： | 1 |
| 7 | QSAR,docking studies and pharmacophore identification of phenylmethyl phenoxy propyl amino propanoic acid derivatives as leukotriene A_4 hydrolase inhibitors显示文摘The enzyme leukotriene A4 (LTA4) plays an important role as precursor of slow reactive substances as LTC4, LTD4, and LTE4. It is an attractive target for molecular modeling and QSAR study. Our effort is mainly focused on exploring the SAR for inhibitors of the LTA4 hydrolase through docking study, pharmacophore modeling and molecular descriptor study. The binding of these small molecules on LTA4 hydrolase enzyme was described by the models developed on 2D molecular descriptors, with good predictive power (39 compounds, 6 descriptors, r2 0.98, SEE 0.167, F-value 268.53, q2 0.90, r2adj 0.97, P-value < 0.0001, SD of residuals 0.15). Docking studies were employed to presume the probable binding conformation of these analogues and exploring the SAR for the compounds. The novel pharmacophore represents the ligand features that are involved in interactions with the target protein, as well as the space around the ligand occupied by the protein. The efforts are aimed to discover the SAR for the inhibitors of LTA4 hydrolase through techniques of QSAR, docking and pharmacophore. | SONAWANE Lalit V BARI Sanjaykumar B | 2010 | 药学学报2010，45，5： | 1 |
| 8 | Unenhanced helical CT of ureterolithiasis: incidence of secondary urinary tract findings显示文摘 | Yaqoob J Usman MU Bari V | 2004 | J Pak Med Assoc2004，54，1： | 1 |
| 9 | The role of magnetic resonance cholangiopancreatography (MRCP) in obstructive jaundice显示文摘 | Munir K Bari V Yaqoob J | 2004 | J Pak Med Assoc2004，54，3： | 1 |
| 10 | Drotrecogin alfa (acti-ated) in adults with septic shock显示文摘 | Ranieri V M Thompson B T Barie P S etal | 2012 | N Engl J Med2012，366，22： | 1 |
| 11 | Ultrasound differentiation of benign versus malig- nant solid breast masses显示文摘 | Murad M Bari V | 2004 | J Coil Physicians Surg Pak2004，14，3： | 1 |
| 12 | The role of magnetic resonance cholangiopancreatography (MRCP) in obstructive jaundice显示文摘 | Munir K Bari V Yaqoob J | 2004 | J Pak Med Assoc2004，54，3： | 1 |
| 13 | Autonomic control of heart rate and QT interval variability influences arrhythmic risk in long QT syn- drome type l显示文摘 | Porta A Girardengo G Bari V | 2015 | J Am Coil Cardiol2015，65，4： | 1 |
| 14 | Low-temperature oxidation of some Turkish coals显示文摘 | Baris K Kizgut S Didari V | 2012 | Fuel2012，93，： | 1 |
| 15 | A tetrahedronized irregular network based DBMS approach for 3D topographic data modeling显示文摘 | FRISO P PETER V O BARIS M K | 2006 | Progress in Spatial Data Handling2006，，10： | 1 |
| 16 | Properties of Polyester/wool Parent and Air-jet Textured Yarns and Their Fabrics 显示文摘 | V K Kothari S K Bari | 2002 | Indian Journal of Fibre & Textile Research2002，27，6： | 1 |
| 17 | Transcriptional profiling reveals coordinated up-regulation of oxidative metabolism genes in thyroid oncocytic tumors 显示文摘 | Baris O Savagner F Nasser V | 2004 | J Clin Endocrinol Metab2004，89，2： | 1 |
| 18 | The evaluation of hepatocellular carcinoma with biphasic contrast enhanced helical CT scan显示文摘 | Yaqoob J Bari V Usman MU | 2004 | J Pak Med Assoc2004，54，3： | 1 |
| 19 | The role of magnetic resonance cholangiopancreatography (MRCP)in obstructive jaundice显示文摘 | Munir K Bari V Yaqoob J | 2004 | J Pak Med Assoc2004，54，3： | 1 |
| 20 | The role of magnetic resonance cholangiopancreatography (MRCP) in obstructive jaundice显示文摘 | Munir K Bari V Yaqoob J | 2004 | J Pak Med Assoc2004，54，： | 1 |
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