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10篇 您的检索式:作者名="Barnard DE"
    题名 作者 年代 出处 被引量
1Matching words and pictures显示文摘BARNARD K DUYGULU P De FREITAS N 2003Machine Learning Research2003,1,3:1
2Raman investigation ofpigmentary molecules in the molluscan biogenicmatrix 显示文摘Barnard W de Waal D 2006Journal of Raman Spectroscopy2006,37,13:1
3Object recognition as machine translation:Learning a lexicon for a fixed image vocabulary显示文摘Duygulu P Barnard K De Freitas J F G 2002Lecture Notes in Computer science2002,,2353:1
4Hepatic metastases ofchoriocarcinoma : a report of 15 patients 显示文摘Barnard DE Woodward KT Yancy SG 1986Gynecol Oncol1986,25,1:1
5Oxygen and carbon dioxide kinetic challenges for thermophilic mineral bioleaching processes 显示文摘De Kock S H Barnard P Du Plessis C A 2004Biochemical Society Transaction2004,322,:1
6Matching words and pictures显示文摘K Barnard P Duygulu N de Freitas 2003Journal of Machine Learning Research2003,,3:1
7Hepatic metastases of choriocarcinoma:A report of 15 patients显示文摘BARNARD DE WOODWARD KT YANCY SG 1986Gynecologic Oncology1986,25,1:1
8Object recognition as machine translation:learning a lexicon for a fixed image vocabulary显示文摘Duygulu P Barnard K de Freitas J F G 2002Leture Noyes in Computer Science Heidelberg:Springer2002,23,53:1
9Sequence- dependent group scheduling problemsin flexible flow shops 显示文摘Rasaratnam L de Szoeke P Barnard F 2006International Journal of Production Economics2006,102,1:1
10Loss of the BRCA1-PALB2 interaction accelerates p53-associated tumor development in mice显示文摘The BRCA1-PALB2-BRCA2 axis,or the BRCA pathway,plays key roles in genome stability maintenance and suppression of breast and several other cancers.Due to frequent p53 mutations in human BRCA1 breast cancers and mouse mammary tumors from Brcal,Brca2 and Palb2 conditional knockout models,it is often thought that p53 inactivation accelerates BRCA1/2 and PALB2-associated tumorigenesis.Here,we studied tumor development in mice with a mutation in Palb2 that disengages the PALB2-BRCA1 interaction in different Trp53 backgrounds.Rather than mammary tumors,Palb2 and Trp53 compound mutant mice developed,with greatly reduced latencies,lymphomas and sarcomas that are typically associated with germline Trp53 inactivation.Whole exome sequencing failed to identify any significant differences in genomic features between the same tumor types of Trp53 single mutant and Palb2;Trp53 compound mutant mice.These results suggest that loss of the BRCA pathway accelerates p53-associated tumor development,possibly without altering the fundamental tumorigenic processes.Amar H.Mahdi Yanying Huo Ying Chen Pier Selenica Anchal Sharma Elise Merritt Nicola Barnard Chang Chan Shridar Ganesan Jorge S.Reis-Filho Britta Weigelt Subhajyoti De Bing Xia 2022Genes & Diseases2022,9,3:0
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