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| 1 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Efficacy of CFRP- based techniques for the flexural and shear strengthening of concrete beams 显示文摘 | Barros J A O Dias S J E Lima J 1 T | 2007 | Cement and Concrete Composites2007，29，3： | 1 |
| 3 | Primary chemotherapy effect in sentinel node detection in breast cancer显示文摘 | Vigario A Sapienza M T Sampaio A P Piato J R Barros N Barros A | 2003 | Clin Nucl Med2003，28，： | 1 |
| 4 | An investigation of the differential performance of clones of the aphid Sitobion avenae on two host species显示文摘 | BARRO PJ de SHERRATT T N DAVID O | 1995 | Oecologia1995，104，3： | 1 |
| 5 | Modelingage-based maintenance strategies with minimal repairs for sys-tems subject to competing failure modes due to degradation andshocks显示文摘 | HUYNH K T CASTROL T BARROS A | 2012 | European Journal of Operational Research2012，218，1： | 1 |
| 6 | Separation of biodiesel and glycerol using ceramic membranes显示文摘 | SERGI GOMES M C PEREIRA N C DAVANTEL DE BARROS S T | 2010 | JournalofMembraneScience2010，352，2： | 1 |
| 7 | 查看详情显示文摘 | Barros V P Faria A L M acLeod T C O | | 0，，： | 1 |
| 8 | Crystallization, structure and func- tion of plant light-harvesting Complex II 显示文摘 | Barros T Kiihlbrandt W | 2009 | Biochimica et Biophysica Acta2009，1787，6： | 1 |
| 9 | From weather to climate-Seasonal and interannual variability of storms and implications for erosion process in the Himalaya显示文摘 | BARROS A P CHIAO S LANG T J | 2006 | Tectonics Climate and Land?scape Evolution2006，398，： | 1 |
| 10 | Chemical Attraction of Male Crab Spiders(Araneae,Thomisidae) and Kleptoparasitic Flies( Diptera, Milichiidae, and Chloropidae) 显示文摘 | ALDRICH J R BARROS T M | 1995 | Journal of Arachnology1995，23，3： | 1 |
| 11 | Rotavirus NSP1 inhibits expression of typeⅠinterferon by antagonizing the function of interferon regulatory factors IRF3,IRF5,and IRF7显示文摘 | BARRO M PATTON J T | 2007 | J Virol2007，81，9： | 1 |
| 12 | Differential response of the luteal phase and fertility in cattle following ovulation of the first- wave follicle with human chorionic gonadotropin or an agonist of gonadotropin-releasing hormone显示文摘 | E J Schmitt T Diaz C M Barros | 1996 | ANIM SCI1996，74，： | 1 |
| 13 | Antioxidant capacity and mineral content of pulp and peel from commercial cuhivars of citrus from Brazil显示文摘 | Barros H R D Ferreira T A P D Genovese M I | 2012 | Food Chemistry2012，134，4： | 1 |
| 14 | The use of a simplified DAS-ELISA procedure for large-scale detection of Apple chlorotic leaf spot and Apple stem grooving viruses in apple trees over extended sampling periods显示文摘 | COVO L M BARROS M T F | 2001 | Acta Horticulturae2001，1，1： | 1 |
| 15 | Metabolites from algae with economical impact显示文摘 | Cardozo K H M Guaratini T Barros M P | 2007 | Comparative Biochemistry and Physiology C-Toxicology & Pharmacology2007，146，： | 1 |
| 16 | Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of 1FN regulatory factor 3显示文摘 | Barro M Patton J T | 2005 | Proc Natl Acad Sci U S A2005，102，11： | 1 |
| 17 | Role of Kdr and Esterase- Mediated Metabolism in Pyrethroid-resistant Populations of Haematobia irritans(Diptera: Muscidae) in Brazil显示文摘 | GUERRERO F D BARROS A T | 2006 | Med Entomol2006，43，： | 1 |
| 18 | Coherent detection in optical fiber systems 显示文摘 | Ip E Lau A P T Barros D J F | 2008 | Optics Express2008，16，2： | 1 |
| 19 | Stochastic Optim ization of Multiple Reservoir System Operation显示文摘 | Braga B P F Yeh WW-G Becker L Barros M T E | 1991 | Journal of Water Resources Planning and Management1991，117，4： | 1 |
| 20 | Wild and commercial mush- rooms as source of nutrients and nutraceuticals 显示文摘 | Barros L Cruz T Baptista P | 2008 | Food and Chemical Toxicology2008，46，8： | 1 |
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