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| 1 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 2 | Underwater ambient noise meas- urements in aquaculture systems:a survey 显示文摘 | Bart A N Clark J Young J | 2001 | Aquacultural Engio neering2001，25，2： | 1 |
| 3 | Therapeutic strategies in acute intracerebral hemorrhage显示文摘 | H BART B JOSHUA N GOLDSTEIN | 2012 | Neurotherapeutics2012，9，1： | 1 |
| 4 | Density and strength of ties in innovation networks : an analysis of multimedia and biotechnology 显示文摘 | Vietor G Bart N | 2005 | European Management Review2005，2，3： | 1 |
| 5 | Density and strength of ties in innovation networks: an analysis of multimedia and biotechnology 显示文摘 | Vietor G Bart N | 2005 | European Management Rev- iew2005，2，3： | 1 |
| 6 | Mechanism of action of clinically approved adjuvants显示文摘 | Bart N Lambrecht Mirjam Kool Monique AM Willart Hamida Hammad | 2009 | Current Opinion in Immunology2009，，1： | 1 |
| 7 | Differential GnRH and GnRH-receptor mRNA expression patterns in different tissues of the female rat across the estrous cycle显示文摘 | SCHIRMAN-HILDESHEIM T D BART BEN A N | 2005 | Endocrinology2005，146，： | 1 |
| 8 | Survival of zebrafish, (Braehydanio rerio) embryo after immersion in methanol and exposure to ultrasound with implications to cryopreservation显示文摘 | BART A N KYAW H A | 2003 | Aquaculture Research2003，34，： | 1 |
| 9 | Temperature compensation for near infrared reflectance measurement of apple fruit soluble solids contents显示文摘 | Peirs A Scheerlinck N Bart M N | 2003 | Postharvest Biology and Technology2003，30，： | 1 |
| 10 | Pseudopmgression after radiotherapy with concurrent temozolomide for high - grade glioma : clinical observation and working recommendations显示文摘 | risto C Bart N Alex M | 2009 | Surg Neural2009，72，： | 1 |
| 11 | Photoperiodic control of body weight and energy metabolism in Syrian hamsters Mesocricetus auratus : role of pineal gland, melatonin, gonads, and diet显示文摘 | BARTNESS T J WADE G N | 1984 | Endocrinology1984，114，9： | 1 |
| 12 | Diagnostic value of Tei index in detection of chronic heart failure in elderly patients 显示文摘 | BART B LARINA V N | 2008 | Ter Arkh2008，80，4： | 1 |
| 13 | Modelling of induced anisotropic damage in granite显示文摘 | Shao J F Hoxha D Bart M Homand F Duveau Ca Souley M Hoteit N | 1999 | International Journal of Rock Mechanics and Mining Sciences1999，36，8： | 1 |
| 14 | Nondeslructive measurement of fiuit and vegetable quality by means of NIR spectroscopy: A review显示文摘 | Bart M N Katrien B | 2007 | Postharvest biology and technology2007，46，2： | 1 |
| 15 | A brief his try of electronic nose 显示文摘 | Gardner J W Bart lett P N | 1994 | Sensors and Actuators B1994，18，19： | 1 |
| 16 | Pulsed white light in combination with UV-C and heat to reduce storage rot of strawberry显示文摘 | David Marquenie Chris W Michiels Jan F Van Impe Eddie Schrevens Bart N Nicola?? | 2002 | Postharvest Biology and Technology2002，，3： | 1 |
| 17 | On the relations among work value orienta- tions, psychological need satisfaction and job outcomes: A self- determination theory approach 显示文摘 | Maarten V Bart N Christopher P Niemiec Bart S Hans D W Anja V B | 2007 | Journal of Occupational and Organizational Psychology2007，，80： | 1 |
| 18 | Review of sewage sludge management: standards, regulations and analytical meth ods显示文摘 | Bart]omiej M C Jacek N Piotr K | 2015 | J Clean Prod2015，90，： | 1 |
| 19 | Spermatophore cryo- preservation and artificial insemination of black tiger shrimp,Penaeus rnonodon (Fabricius) 显示文摘 | Bart A N Choosuk S Thakur D P | 2006 | Aquacult Re- search2006，37，： | 1 |
| 20 | Numerical solution of the spatially distributed population balance equation describing the hydrodynamics of interacting liquid-liquid dispersions显示文摘 | Attarakih M M Bart H J Faqir N M | | 0，，： | 1 |
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