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| 1 | Hypoxia inducible factor-1αaccumulation in steatotic liver preservation:Role of nitric oxide显示文摘AIM:To examine the relevance of hypoxia inducible factor(HIF-1)and nitric oxide(NO)on the preservation of fatty liver against cold ischemia-reperfusion injury(IRI). METHODS:We used an isolated perfused rat liver model and we evaluated HIF-1αin steatotic and non-steatotic livers preserved for 24 h at 4℃in University of Wisconsin and IGL-1 solutions,and then subjected to 2 h of normothermic reperfusion.After normoxic reperfusion,liver enzymes,bile production,bromosulfophthalein clearance,as well as HIF-1αand NO[endothelial NO synthase(eNOS)activity and nitrites/nitrates]were also measured.Other factors associated with the higher susceptibility of steatotic livers to IRI,such as mitochondrial damage and vascular resistance were evaluated. RESULTS:A significant increase in HIF-1αwas found in steatotic and non-steatotic livers preserved in IGL-1 after cold storage.Livers preserved in IGL-1 showed a significant attenuation of liver injury and improvement in liver function parameters.These benefits were enhanced by the addition of trimetazidine(an antiischemic drug),which induces NO and eNOS activation, to IGL-1 solution.In normoxic reperfusion,the presence of NO favors HIF-1αaccumulation,promoting also the activation of other cytoprotective genes,such as hemeoxygenase-1. CONCLUSION:We found evidence for the role of the HIF-1α/NO system in fatty liver preservation,especially when IGL-1 solution is used. | Mohamed Amine Zaouali Ismail Ben Mosbah Eleonora Boncompagni Hassen Ben Abdennebi Maria Teresa Mitjavila Ramon Bartrons Isabel Freitas Antoni Rimola Joan Roselló-Catafau | 2010 | World Journal of Gastroenterology2010，16，28： | 11 |
| 2 | TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis显示文摘 | Karim Bensaad Atsushi Tsuruta Mary A. Selak M. Nieves Calvo Vidal Katsunori Nakano Ramon Bartrons Eyal Gottlieb Karen H. Vousden | 2006 | Cell2006，，1： | 3 |
| 3 | Hepatic preconditioning preserves energy metabolism during sustained ischemia显示文摘 | Peralta C Bartrons R Riera L | 2000 | Am J Physiol2000，279，： | 1 |
| 4 | The Combination of Ischemie Preconditioning and Liver Bcl - 20verexpression Is a Suitable Strategy to Prevent Liver and Lung Damage after Hepatic Isehemia - Reperfusion 显示文摘 | Carmen Peralta Jose Carlos Perales Ramon Bartrons | 2002 | Am J Pathol2002，160，6： | 1 |
| 5 | Ductus Arteriosus Patency With Stenting in Critical Pulmonary Stenosis and Pulmonary Atres ia With Intact Interventricular Septum显示文摘 | Mortera C Rissech M Bartrons J | 2005 | Revista Espanola de Ca rdiologiy2005，58，5： | 1 |
| 6 | Assisted Reproductive Technologies Are Associated With Cardiovascular Remodeling In Utero That Persists Postnatally显示文摘 | Brenda Valenzuela-Alcaraz Fàtima Crispi Bart Bijnens Monica Cruz-Lemini Montserrat Creus Marta Sitges Joaquim Bartrons Salvadora Civico Juan Balasch Eduard Gratacós | 2013 | Circulation2013，，13： | 1 |
| 7 | Altitudinal gradients of PBDEs and PCBs in fishfrom European high mountain lakes显示文摘 | Gallego E Grimalt JO Bartrons M | 2007 | Environmental Science and Technology2007，41，7： | 1 |
| 8 | Hypoxia, glucose metabolism and the Warburg's effect 显示文摘 | Bartrons R Caro J | 2007 | J Bioenerg Biomembr2007，39，3： | 1 |
| 9 | Hepatic preconditioning preserves energy metabolism during sustained ischemia显示文摘 | Peralta C Bartrons R Riera L | 2000 | Am J Physiol2000，279，1： | 1 |
| 10 | Hypoxia, glucose metabolism and the Warburg's effect 显示文摘 | Bartrons R Cam J | 2007 | J Bioenerg Biomembr2007，39，3： | 1 |
| 11 | Adenosine monophosphate-activated protein kinase mediates the protective effects of ischemic preconditioning on hepatic ischemia- reperfusion injury in the rat显示文摘 | Peralta C Bartrons R Serafin A | 2001 | Hepatology2001，34，6： | 1 |
| 12 | PFKFB3 gene silencing decreases glycolysis,induces cell-cycle delay and inhibits anchorage-independent growth in HeLa cells 显示文摘 | CALVO M N BARTRONS R CASTANO E | 2006 | FEBS Lett2006，580，13： | 1 |
| 13 | Hypoxia, glucose metabolism and the War burg's effect 显示文摘 | Bartrons R Caro J | 2007 | J Bioenerg Biomembr2007，39，3： | 1 |
| 14 | Accuracy of tour-dimensional spatiotemporal image correlation echocardiography in the prenatal diagnosis of con- genital heart defects显示文摘 | Bartrons J | 2010 | Ultrasound in obstetrics & gynecolo- gy2010，36，4： | 1 |
| 15 | Effect of ozone treatment on reactive oxygen species and asenosine production during hepatic ischemia-reperfusion显示文摘 | Peralta C Xaus C Bartrons R Leon OS Gelpi E Rosello-Catafau J | 2000 | Free Radic Res2000，33，8： | 1 |
| 16 | Altitudinal distributions of BDE- 209 and other polybromodiphenyl ethers in high mountain lakes显示文摘 | Bartrons M Grimalt JO Catalan J | 2011 | Environ Pollut2011，159，： | 1 |
| 17 | Hypoxia, glucose metabolism and the Warburg's effect 显示文摘 | Ramon Bartrons Jaime Caro | 2007 | J Bioenerg Biomembr2007，39，3： | 1 |
| 18 | Hybridization in freshwater fishes:a review of case studies and cytonuclear methods of biological inference显示文摘 | SCRIBNER KIM T PAGE KEVIN S BARTRON MEREDITH L | 2001 | Review in Fish Biology and Fisheries2001，10，： | 1 |
| 19 | Amino acids activate roTOR complex 2 via PI3K/Akt signalling显示文摘 | Tato I Bartrons R Ventura F | 2010 | J Biol Chem2010，286，： | 1 |
| 20 | Adenosine monophosphate - activated protein kinase mediates the pro-tective effects of ischemic preconditioning on hepatic ischemic - reperfusion injury in the rat显示文摘 | PERALTA C BARTRONS R SERAFIN A | 2001 | Hepatology2001，34，6： | 1 |
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