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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Electron gun and collector design for 94 GHz gyro amplifiers显示文摘 | Nguyen K T Danly B G Baruch L | 1998 | IEEE Trans Plasma Science1998，26，3： | 1 |
| 3 | Can nucleotides prevent Cu - induced oxidative damage? 显示文摘 | Baruch - Suchodolsky R Fischer B | 2008 | J Inorg Biochem2008，102，4： | 1 |
| 4 | Optimal Weighted Or thogonalization of Measured Modes显示文摘 | BARUCH M ITZHACK Y B | 1978 | AIIA Journal1978，16，4： | 1 |
| 5 | Exploiting the manufacturing-services interface显示文摘 | QUINN J B BARUCH J J PAQUETTE P C | 1988 | Sloan Management Review1988，，： | 1 |
| 6 | Neoadjuvant chemotherapy before liver resection for patients with unresectable liver metastases from eoloreetal earcinoma显示文摘 | GREGORY D L BARUCH B NACY E K | 2005 | J Clin Oncol2005，23，9： | 1 |
| 7 | DNA immunization with the cysteine-rich interdomain region 1 of the Plasmodium falciparum variant antigen elicits limited cross-reactive antibody responses显示文摘 | BARUCH DI GAMAN B MILLER LH | 2003 | Infect Immun2003，71，： | 1 |
| 8 | Alteration of hemodynamics in aneurysm models by stenting: influence of stent porosity显示文摘 | BARUCH B ALFRED P AJAY K | 1997 | Annals of Biomedical Engineering1997，25，： | 1 |
| 9 | Tricuspid valve replacement: the effect of gender on operative results 显示文摘 | Leviner DB Medalion B Baruch I | 2014 | J Heart Valve Dis2014，23，2： | 1 |
| 10 | Exploiting the manufacturing-services interface显示文摘 | QUINN J B BARUCH J J PAQUETYE P C | 1988 | Sloan Management Review1988，32，7： | 1 |
| 11 | Advantage of the presence of living dermal fibroblasts within in vitro reconstructed skin for grafting in humans显示文摘 | Coulomb B Friteau L Baruch J | 1998 | Plast Reconstr Surg1998，101，7： | 1 |
| 12 | Fine diamond turning of KDP crystals显示文摘 | BARUCH A F PAUL H P PHILIP C B | 1986 | Applied Optics1986，25，11： | 1 |
| 13 | Can patients at elevated risk of stroke treated with anticoagulants be further risk strat- ified?显示文摘 | Baruch L Gage B F Horrow J Juul-Moller S Labovitz A Persson M | 2007 | Stroke2007，38，： | 1 |
| 14 | The worldwide leaf economics spectrum显示文摘 | Wright I J Reich P B Westoby M Ackedy D D Baruch Z Bongers F Cavender-Bares J Chapin T Comellssen J H C Diemer M Flexas J Gamier E Groom P K Gullas J Hikosaka K Lamont B B Lee T Lee W Lusk C Midgley J J Navas M Niinemets U Oleksyn J Osada N Poorter H Poot P Prior L Pyankov V I Roumet C Thomas S C Veneklaas E J Villar R | 2004 | Nature2004，428，： | 1 |
| 15 | Exploiting the manufacturing-services interface显示文摘 | QUINN J B BARUCH J J PAQUETTE P C | 1988 | Sloan Management Review1988，29，4： | 1 |
| 16 | Advantage of the presence of living dermalfibroblasts with in vitro reconstructed skin for grafting in humans 显示文摘 | Fritean L Baruch J | 1998 | Plast Reconstr Surg1998，101，： | 1 |
| 17 | Neoadjuvant chemotherapy before liver resection for patients with unresectable liver metastases from colorectal carcinoma显示文摘 | Gregory DL Baruch B Nacy EK | 2005 | J Clin Oncol2005，23，9： | 1 |
| 18 | Neoadjuvant chemotherapy be- fore liver resection for patients with unresectable livermetastases from colorectal carcinoma 显示文摘 | Gregory DL Baruch B Nancy EK | 2005 | J Clin Oncol2005，23，： | 1 |
| 19 | Exploiting the Manufacturing-Ser- vices lnterface显示文摘 | Quinn J B Baruch J J Paquette P C | 1988 | Sloan Management Review1988，，： | 1 |
| 20 | Exploiting the manufacturing-services in interface显示文摘 | QUINN J B BARUCH J PAQUETTE P C | 1988 | Sloan Management Review1988，29，4： | 1 |
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