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您的检索式：作者名="Basste Hadjab"
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| 1 | Study of biological markers in skin quality treatment by subcutaneous injection of a stabilized composition of 26 mg/mL of high molecular weight HA显示文摘Aim:Hyaluronic acid(HA)injectables have gained rapid acceptance for the treatment of skin rejuvenation.A novel HA/sorbitol composition intended for skin quality improvement containing 2.6%of high molecular weight HA stabilized by sorbitol was recently designed to be injected subcutaneously.The aim of this study was to assess the expression of biological markers of skin quality after administration of the composition.Methods:The HA/sorbitol composition was evaluated after injection into the superficial adipose tissue with ex vivo cultured human skin explants versus a product comparator to study the general morphology of the skin tissues and the expression of HA,elastin,collagen type Ⅰ,collagen type Ⅲ,and fibrillin-1 in the dermal layer.Results:The results demonstrate that the HA/sorbitol composition is able to boost the production of HA,elastin,collagen type Ⅰ,collagen type Ⅲ,and fibrillin-1 in the dermis while providing a proper quality of skin morphology.Conclusion:The HA/sorbitol composition improved biological markers of skin quality in the dermis after product injection into the superficial adipose tissue.This novel composition can be considered as an attractive solution to treat skin aging by injecting a specific HA/sorbitol formulation to strategically target the subcutaneous tissue to improve the quality of the different layers of the skin. | Jérémie Bon Bétemps Samuel Gavard Molliard Basste Hadjab Mhd Badi Anas Ghazal Marco Cerrano | 2022 | Plastic and Aesthetic Research2022，9，1： | 0 |
| 2 | Stabilized composition of 26 mg/mL of high molecular weight HA for subcutaneous injection to improve skin quality显示文摘Aim:Skin firmness is one of the key parameters to define skin quality and facial aging.Among the minimally invasive anti-aging strategies,hyaluronic acid(HA)injection is widely accepted to improve skin quality.While most of the available HA injectables are designed and intended for intradermal injection,a novel HA/sorbitol composition containing 2.6% high molecular weight hyaluronic acid stabilized by sorbitol was recently developed to be specifically injected into the adipose tissue to improve the quality of all skin layers,especially the skin firmness.Methods:The HA/sorbitol composition was investigated versus product comparators in terms of biophysical properties,tolerance in subcutaneous tissue with in vivo implantation study,and skin firmness assessment on human skin explants.Results:The HA/sorbitol composition was characterized by unique and differentiated biophysical properties,proper distribution and high tolerance of the gel composition into the adipose tissue,and the ability to efficiently improve skin firmness.Conclusion:The HA/sorbitol composition represents a new attractive solution to treat facial skin aging with an injection strategy specifically targeting the adipose tissue instead of the dermis,to improve the quality of the skin. | Samuel Gavard Molliard Jérémie Bon Bétemps Basste Hadjab Anas Ghazal Mhd Badi Marco Cerrano | 2022 | Plastic and Aesthetic Research2022，9，1： | 0 |
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