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| 1 | Interleukin-1 and TNF-α polymorphisms and Helicobacter pylori in a Brazilian Amazon population显示文摘AIM:To study the association between Interleukin-1(IL-1)and tumor necrosis factor(TNF)-αpolymorphisms,infection by Helicobacter pylori(H pylori)and the development of gastrointestinal diseases.METHODS:Genomic DNA was extracted from the peripheral blood of 177 patients with various gastrointestinal diseases and from 100 healthy volunteers.The polymorphisms in IL-1βand TNF-αgenes were analyzed using the polymerase chain reactionrestriction fragment length polymorphism method(PCRRFLP)and those from IL-1RN with PCR.The presence of infection due to H pylori and the presence of the CagA toxin were detected by serology.The histopathological parameters in the gastric biopsies of the patients were according to the Sydney classification.RESULTS:A comparison of the frequencies of the different polymorphisms studied among the patients and the control group demonstrated that the allele IL1RN*2 was more frequent among patients with gastric ulcers and adenocarcinoma.Carriers of the allele ILRN*2 and those with reactive serology for anti-CagA IgG had a greater risk of developing peptic ulcer and gastric adenocarcinoma,as well as a higher degree of inflammation and neutrophilic activity in the gastric mucosa.CONCLUSION:Our results indicate a positive association between IL-1RN gene polymorphism and infection by positive H pylori CagA strains and the development of gastric ulcers and adenocarcinoma. | Hivana Patricia Melo Barbosa Luisa Caricio Martins Sidney Emanuel Batista dos Santos Samia Demachki Mnica Baraúna Assumpo Charliana Damasceno Arago Tereza Cristina de Oliveira Corvelo | 2009 | World Journal of Gastroenterology2009，15，12： | 17 |
| 2 | 灿烂弧菌对厚壳贻贝免疫指标和消化酶活性的影响显示文摘为探究灿烂弧菌对厚壳贻贝免疫指标和消化酶活性的影响,用1×10~6、1×10~7、1×10~8个/mL 3个浓度的灿烂弧菌刺激厚壳贻贝,探讨弧菌刺激后厚壳贻贝的一氧化氮合酶(NOS)、一氧化氮(NO)、超氧化物歧化酶(SOD)、丙二醛(MAD)等免疫指标和淀粉酶、蛋白酶等消化酶的变化情况。结果显示,灿烂弧菌刺激48 h后,厚壳贻贝足、鳃、消化腺等组织中仅消化腺的NOS活性较对照组有显著升高,且酶活性随初始细菌浓度的升高而升高,故选用消化腺来测定灿烂弧菌刺激后72 h内的免疫指标和消化酶活性的变化。灿烂弧菌刺激后,48 h内NOS活性较对照组均显著升高。NO含量较对照组均显著升高,与NOS显现相同变化趋势。SOD活性在各浓度灿烂弧菌刺激下较对照组均显著升高,而MAD含量在实验组中含量显著低于对照组。淀粉酶活性在实验组中显著低于对照组,总体呈现先下降后升高的趋势。蛋白酶活性在各实验组中均呈现先升高后下降的趋势。研究表明,灿烂弧菌对厚壳贻贝免疫指标和蛋白酶活性的升高有诱导作用,但对蛋白酶的活性有抑制作用。本研究初步探明了厚壳贻贝对灿烂弧菌的免疫应答机制,为进一步研究灿烂弧菌和厚壳贻贝相互作用机制以及厚壳贻贝免疫机制奠定了基础。 | 梁箫 张亚 刘钰珠 李一峰 BATISTA M F POWER D 杨金龙 | 2018 | 水产学报2018，42，9： | 5 |
| 3 | Biogeochemistry inNeves Corvo mining region,Iberian Pyrite Belt,Portugal显示文摘 | Batista M J Abreu M M Serrano P M | 2007 | Journal of Geochemical Exploration2007，92，23： | 3 |
| 4 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 5 | The effect of removal of seminal plasma, egg yolk level and season on sperm freezabili- ty of Canary buck (Capra hircus) 显示文摘 | Cabrera F Gonzfdez F Batista M | 2005 | Reprod Dom Anim2005，40，3： | 1 |
| 6 | Effects of taurine supplementation upon food intake and central insulin signaling in malnourished mice fed on a high-fat diet显示文摘 | Camargo R L Batista T M Ribeiro R A | 2013 | Advances in Experi- mental Medicine and Biology2013，4776，： | 1 |
| 7 | High efficiency steam reforming of ethanol by cobalt-based catalysts显示文摘 | Batista M S Santos R K S M Assaf E M | 2004 | J Power Sources2004，134，1： | 1 |
| 8 | A Study of the Behavior of Several Methods for Balancing Machine Learning TrainingData显示文摘 | Batista G E A Prati R C Monard M C | 2004 | ACM SIGKDD Explorations Newsletter2004，6，1： | 1 |
| 9 | Anti-inflammatory effect of physical training in heartfailure:role of TNF-alpha and IL-10显示文摘 | BATISTA M L Jr LOPES R D SEELAENDER M C | 2010 | Cardiol2010，95，2： | 1 |
| 10 | A study of k-nearest neighbor as a model-based to treat missing data 显示文摘 | Batista G E Menards M C | 2003 | Proeeedings of the Argentine Symposium on Artificial Intelligence2003，，30： | 1 |
| 11 | Implementation of advanced analysis method for steel-framed structures under fire conditions显示文摘 | Landesmann Alexandre de M Batista Eduardo | 2005 | Fire Safety Journal2005，40，4： | 1 |
| 12 | Characterization of the activity and stability of supported cobalt catalysts for the steam reforming of ethanol显示文摘 | Batista M S Santos R K S M Assaf E M | 2003 | J Power Sources2003，24，1： | 1 |
| 13 | Is it possible to compare researchers with different scientific interests 显示文摘 | BATISTA P D CAMPITELI M G KINOUCHI O | 2006 | Scientometrics2006，68，1： | 1 |
| 14 | Effects of periodontal dressings on fibroblasts and gingival wound healing in dogs 显示文摘 | Petelin M Pavlica Z Batista U | 2004 | Acta Vet Hung2004，52，1： | 1 |
| 15 | The accuracy of seven mathematical function in modeling dairy cattle lactation curves based on testday records from varying sample schemes显示文摘 | SILVESTRE A M PETIMBATISTA F COLACO J | 2006 | J Dairy Sci2006，89，： | 1 |
| 16 | Accessing gelling ability of vegetable proteins using rheological and fluorescence techniques显示文摘 | Ana Paula Batista Carla A M Portugal Isabel Sousa | 2005 | International Journal of Biological Macromolecules2005，36，： | 1 |
| 17 | Analysis of in vitro and in vivo anti oxi-dant properties of hydrophilic fractions from theseaweed halimeda monile 显示文摘 | Batista Gonzalez A E Silva A M D 0 E Vidal-NovoaA | 2012 | Journal of Food Bio-chemistry2012，36，2： | 1 |
| 18 | Gastric antiulcer activity of Syngonanthus arthrotrichus SILVEIRA 显示文摘 | Batista L M de Almeida ABA Magri L D | 2004 | Biol Pharm Bull2004，27，3： | 1 |
| 19 | Lidar observations of atmospheric sodium at an equatorial location显示文摘 | Clemesha B R Simonich D M Batista P P | 1998 | Journal of Atmospheric and Solar-Terrestrial Physics1998，60，： | 1 |
| 20 | Taurine supplementation restores glucose and carbachol-induced insulin secretion in islets from low-protein diet rats:involvement of Ach-M3R,Synt 1 and SNAP-25 proteins显示文摘 | BATISTA T M RIBEIRO R A AMARAL A G | 2012 | Journal of Nutritional Biochemistry2012，23，： | 1 |
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