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| 1 | Octreotide induces caspase activation and apoptosis in human hepatoma HepG2 cells显示文摘AIM: To investigate the role of octreotide on cellular proliferation and apoptosis of human hepatoma (HepG2) cells. METHODS: We studied cellular proliferation, apoptosis and the possible internal caspase-mediated apoptosis pathway involved, after treatment of HepG2 carcinoma cells with octreotide in comparison with the apoptosis caused by tumor necrosis factor-α (TNF-α). Activities of caspase-3, caspase-9, caspase-8 and caspase-2 were studied, while apoptosis was investigated through detection of DNA fragmentation and through identification of apoptotic cells with the annexin-V/propidium iodide flow cytometric method. RESULTS: After an initial increase in HepG2 cellular proliferation, a significant inhibition was observed with 10-8 mol/L octreotide, while TNF-α dose-dependently decreased proliferation. Early and late apoptosis was significantly increased with both substances. Octreotide significantly increased caspase-3, caspase-8 and caspase-2 activity. TNF-α signifi cantly increased only caspase-2. Cellular proliferation was decreased after treatment with octreotide or TNF-α alone but, in contrast to TNF-α, octreotide decreased proliferation only at concentrations of 10-8 mol/L, while lower concentrations increased proliferation. CONCLUSION: Our findings are suggestive of caspasemediated signaling pathways of octreotide antitumor activity in HepG2 cells, and indicate that measurements of serum octreotide levels may be important, at least in clinical trials, to verify optimal therapeutic drug concentrations. | Nikos J Tsagarakis Ioannis Drygiannakis Antonis G Batistakis George Kolios Elias A Kouroumalis | 2011 | World Journal of Gastroenterology2011，17，3： | 5 |
| 2 | On clustering validation techniques 显示文摘 | HALKIDI M BATISTAKIS Y VAZIRGIANNIS M | 2001 | Intelligent Information Systems2001，17，23： | 1 |
| 3 | Clustering validity checking methods: Part II显示文摘 | HALKIDI M BATISTAKIS Y VAZIRGIANNIS M | 2002 | ACM Sigmod Record2002，31，3： | 1 |
| 4 | On clustering validation techniques显示文摘 | Halkidi M Batistakis Y Vazirgiannis M | 2001 | Journal of Intelligent Information Systems Springer2001，17，23： | 1 |
| 5 | On Clustering Validation Techniques显示文摘 | Halkidi M Batistakis Y Vazrgiannis M | 2001 | Intelligent in Formation Systems2001，17，23： | 1 |
| 6 | Clustering validity checking methods : Part 11 显示文摘 | Halkidi M Batistakis Y Vazirgiannis M | 2002 | AC M IGMOD Record2002，31，3： | 1 |
| 7 | On clustering validation techniques 显示文摘 | HALKIDI M BATISTAKIS Y VAZIRGIANNIS M | 2001 | Intelligent Information Systems2001，17，23： | 1 |
| 8 | On Clustering Validation Techniques显示文摘 | Halkidi M Batistakis Y Vazirgiannis M | 2001 | Journal of Intelligent Information Systems2001，17，23： | 1 |
| 9 | Clustering validity checking methods : part I 显示文摘 | HALKIDI M BATISTAKIS Y VAZIRGIANNIS M | 2002 | ACM SIG- MOD Record2002，31，3： | 1 |
| 10 | Clustering validity checking methods:Part Ⅱ显示文摘 | Maria Halkidi Yannis Batistakis Michalis Vazirgiannis | 2002 | ACM SIGMOD Record2002，31，3： | 1 |
| 11 | Clustering algorithms and validity measures显示文摘 | Halkidi M Batistakis Y Vazirgiannis M | 2001 | IEEE Computer2001，3，： | 1 |
| 12 | On clustering validation techniques显示文摘 | Maria Halkidi Yannis Batistakis Michalis Vazirgiannis | 2001 | Journal of Intelligent Information Systems2001，17，23： | 1 |
| 13 | Carbimazole induced acute cholestatic hepatitis显示文摘 | Mazokopakis EE Drygiannakis IA Batistakis AG | 2007 | Endocrinolagist2007，17，： | 1 |
| 14 | Bilateral thoracic splanchnic nerve radiofrequency thermocoagulation for the management of end-stage pancreatic abdominal cancer pain显示文摘 | Papadopoulos D Kostopanagiotou G Batistaki C | | 0，，02： | 1 |
| 15 | On clustering validation techniques 显示文摘 | HALKIDI M BATISTAKIS Y VAZIRGIANNIS M | 2001 | Journal of intelligent information systems2001，17，23： | 1 |
| 16 | Clustering Validity Checking Methods:Part Ⅱ显示文摘 | Maria Halkidi Yannis Batistakis Michalis Vazirgiannis | 2002 | ACM SIGMOD Record2002，31，3： | 1 |
| 17 | Carbimazole-induced acute cholestatic hepatitis显示文摘 | Mazokopakis EE Drygiannakis IA Batistakis AG | 2007 | Endocrinologist2007，17，： | 1 |
| 18 | Quality scheme assessment in the clustering process 显示文摘 | Halkidi M Vazirgianni8 M Batistakis Y | 2013 | Principles of Data Mining and Knowledge Discovery2013，5，6： | 1 |
| 19 | Cluster validity methods: Part Ⅱ显示文摘 | Halkidi M Batistakis Y Vazirgiannis M | 2002 | SIGMOD Record2002，31，3： | 1 |
| 20 | On Clustering Validation Techniques 显示文摘 | Halkidi M Batistakis Y Vazirgiannis M | 2001 | Journal of Intelligent Informa-tion Systems2001，17，23： | 1 |
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