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| 1 | Plasma free amino acid profiling of esophageal cancer using high-performance liquid chromatography spectroscopy显示文摘AIM:To perform plasma free amino acid(PFAA)profiling of esophageal squamous cell carcinoma(ESCC)patients at different pathological stages and healthy subjects.METHODS:Plasma samples from ESCC patients(n=51)and healthy control adults(n=60)were analyzed by high-performance liquid chromatography(HPLC).The ESCC patients included moderate/poorly-differentiation(n=24),lymph node metastasis(n=17)and clinical stage>Ib2(n=36).Partial least squares discriminant analysis was performed to demonstrate that the PFAA metabolic patterns enabled discrimination between ESCC patients and controls,and the Student t test was applied to assess significant differences in PFAA concentrations between the two groups.RESULTS:There were significant differences in the PFAA profiles between controls and ESCC patients.Compared with healthy controls,the levels of Asp,Glu,Gly,His,Thr,Tau,Ala,Met,Ile,Leu,and Phe were decreased in ESCC patients,but Cys was increased.There exists a strong correlation between PFAA profiles and clinicopathological characteristics in ESCC patients.The levels of many PFAAs(i.e.,Glu,Asp,Ser,Gly,Tau,Ala,Tyr,Val,Ile,and Leu)were related to pathological grading,lymph node metastasis,and ESCC clinical stage.Very good discrimination between ESCC patients and control subjects was achieved by multivariate modeling of plasma profiles.CONCLUSION:HPLC-based plasma profiling analysis was shown to be an effective approach to differentiate between ESCC patients and controls.PFAA profiles may have potential value for screening or diagnosing ESCC. | Hong Ma Ayshamgul Hasim Batur Mamtimin Bin Kong Hai-Ping Zhang Ilyar Sheyhidin | 2014 | World Journal of Gastroenterology2014，20，26： | 11 |
| 2 | Spatio-temporal patterns of drought in North Xinjiang, China, 1961–2012 based on meteorological drought index显示文摘Drought, which is one of the most frequently occurring severe hazards with long time scales and covering wide geographical areas, is a natural phenomenon resulting in significant economic losses in agriculture and industry. Drought is caused by an imbalance between the inputs of and the demand for water which is insufficient to meet the demands of human activities and the eco-environment. As a major arid and semi-arid area and an important agricultural region in Northwest China, North Xinjiang(NX) shows great vulnerability to drought. In this paper, the characteristics of inter-annual and seasonal drought were analyzed in terms of drought occurrence and drought coverage, by using the composite index of meteorological drought and the data of daily precipitation, air temperature, wind speed, relative humidity and sunshine duration from 38 meteorological stations during the period 1961–2012. Trend analysis, wavelet analysis and empirical orthogonal function were also applied to investigate change trend, period and regional characteristics, respectively. In NX, annual and seasonal drought occurrence and drought coverage all showed a decreasing trend that was most significant in winter(with rates of –0.26 month/10 a and –15.46%, respectively), and drought occurrence in spring and summer were more frequent than that in autumn and winter. Spatially, drought was severe in eastern regions but mild in western regions of NX. Annual and seasonal drought occurrence at 38 meteorological stations displayed decreasing trends and were most significant in 'Shihezi-Urumqi-Changji', which can help to alleviate severe drought hazards for local agricultural production and improve human livelihood. NX can be approximately classified into three sub-regions(severe drought region, moderate drought region and mild drought region), which were calculated from annual drought frequencies. The cross wavelet transform suggested that SOI(Southern Oscillation Index), AOI(Arctic Oscillation Index), AAOI(Antarctic Oscillation Index), PAOI(Pacific/North American Oscillation Index) and NAOI(North Atlantic Oscillation Index) have significant correlation with the variation of drought occurrence in NX. To prevent and mitigate the occurrence of drought disasters in NX, agricultural and government managers should pay more attention to those drought events that occur in spring and summer. | WU Yanfeng Batur BAKE ZHANG Jusong Hamid RASULOV | 2015 | Journal of Arid Land2015，7，4： | 8 |
| 3 | Decreased blood riboflavin levels are correlated with defective expression of RFT2 gene in gastric cancer显示文摘AIM:To investigate the relationship between blood riboflavin levels and riboflavin transporter 2(RFT2) gene expression in gastric carcinoma(GC) development.METHODS:High-performance liquid chromatography was used to detect blood riboflavin levels in patients with GC.Real-time fluorogenic quantitative polymerase chain reaction and immunohistochemistry were used to analyze the expression of RFT2 mRNA and protein in samples from 60 GC patients consisting of both tumor and normal tissue.RESULTS:A significant decrease in the RFT2 mRNA levels was detected in GC samples compared with those in the normal mucous membrane(0.398 ± 0.149 vs 1.479 ± 0.587;P = 0.040).Tumors exhibited low RFT2 protein expression(75%,16.7%,8.3% and 0% for no RFT2 staining,weak staining,medium staining and strong staining,respectively),which was significantly lower than that in the normal mucous membrane(10%,16.7%,26.7% and 46.7% for no RFT2 staining,weak staining,medium staining and strong staining,respectively;P < 0.05).Tumors with low RFT2 expression were significantly associated with tumor stage and histological grade.Moreover,a significantly decrease in Uyghur patients was observed compared with Han patients.However,other parameters-gender,tumor location and lymph node metastasis-showed no significant relationship with RFT2 expression.Blood riboflavin levels were reverse correlated with development of GC(1.2000 ± 0.97 569 ng/mL in high tumor stage patients vs 2.5980 ± 1.31 129 ng/mL in low tumor stage patients;P < 0.05).A positive correlation of plasma riboflavin levels with defective expression of RFT2 protein was found in GC patients(2 = 2.619;P = 0.019).CONCLUSION:Defective expression of RFT2 is associated with the development of GC and this may represent a mechanism underlying the decreased plasma riboflavin levels in GC. | Maynur Eli De-Sheng Li Wei-Wei Zhang Bing Kong Chen-Song Du Maimaitiaili Wumar Batur Mamtimin Ilyar Sheyhidin Ayshamgul Hasim | 2012 | World Journal of Gastroenterology2012，18，24： | 6 |
| 4 | An magnetic resonance-based plasma metabonomic investigation on abnormal Savda in different complicated diseases显示文摘OBJECTIVE: To provide potential evidence for the existence of abnormal Savda, we assessed host metabonomic responses and dynamic changes occurring in various diseases using1H nuclear magnetic resonance(NMR)-based metabonomics.METHODS: Plasma samples taken from patients with complicated diseases with abnormal Savda(n=140, including 35 cases each of diabetes, asthma,breast cancer, and cervical carcinoma) and from healthy controls(n=35) were analyzed by1H NMR(600 MHz), and the spectral profiles were analyzed by multivariate analysis using orthogonal projection to latent structure with discriminant analysis.RESULTS: Supervised modeling of the data provided very good discrimination between patients and healthy controls. Compared with the healthy controls, the patient groups with different disease conditions displayed similar metabolic changes, characterized by lower creatine, creatinine, lactate, and amino acid levels(including isoleucine, leucine, valine, alanine, and 1-methylhistidine) and higher lipid levels(very low-density lipoproteins and unsaturated lipids). Additionally, cancer patients(breast and cervical) showed decreased myo-inositol,α-glucose, and β-glucose, and increased pyruvate and carnitine in plasma.CONCLUSION:The data indicate that decreased oxidative defense, liver function abnormalities, amino acid deficiencies, and energy metabolism disorders are common characteristics of complicated diseases, which may be related to the formation of abnormal Savda. | Batur Mamtimin Mawlanjan Hizbulla Nazuk Kurbantay Li You Xinghai Yan Halmurat Upur | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 5 |
| 5 | 铵(氨)循环工艺-碳氨法制备碳酸钙的研究显示文摘含钙碳酸盐矿物可以经过煅烧制备石灰(CaCO_3■CaO+CO_2↑),同时产生二氧化碳副产物。(熟)石灰常用于制备氨气[Ca(OH)_2+2NH_4Cl→CaCl_2+2NH_3↑+2H_2O],同时产生无太大经济价值的氯化钙副产物。研究了用反应'CaCl_2+CO_2+H_2O+2NH_3→CaCO_3↓+2NH_4Cl'制备轻质碳酸钙(定义为碳氨法)。如果碳氨法获得应用,结合上述两个反应过程(即铵循环工艺),制备碳酸钙的总反应将为CaCO_3→CaCO_3,这样碳酸钙的生产过程在理论上无任何副产物产生。详细研究了碳氨法生成碳酸钙的反应特征、如何用碳氨法制备具有不同形貌和结构的碳酸钙产品,以及相应的反应机理。这些研究为利用储量巨大的含钙碳酸盐矿物(例如方解石、石灰石和白云石)生产高附加值产品提供了重要的思路和理论基础。 | 徐梓淮 Nafiu Sadi Bature 范天博 丁杨 刘云义 郭洪范 | 2019 | 无机盐工业2019，51，4： | 4 |
| 6 | Efficacy of insulin-sensitizing agents in nonalcoholic fatty liver disease显示文摘 | Ziya Omer Sevki Cetinkalp Murat Akyildiz Funda Yilmaz Yucel Batur Candeger Yilmaz Ulus Akarca | 2010 | European Journal of Gastroenterology & Hepatology2010，，1： | 2 |
| 7 | MgCl_2溶液中杂质离子的存在对氨气法制备Mg(OH)_2粒径的影响显示文摘MgCl_2是Mg(OH)_2 (MH)化学沉淀中常用的前驱体,但来自海水、菱镁矿和白云石等的MgCl_2中可能存在一些杂质,可能会影响所制备MH的质量。介绍了在MgCl_2溶液中分别加入不同种类的杂质离子,通过氨气沉淀法制备Mg(OH)_2(MH)产品,以此研究杂质离子的存在对所制备MH产品粒径的影响规律。实验结果表明,在MgCl_2溶液中阳离子的存在对所制备MH的粒径没有明显的影响,但阴离子的存在对所制备MH的粒径有显著的影响。当多价阴离子或单价AC^-存在时,甚至当杂质离子与MgCl_2的摩尔比低至1:120时,所制备的MH的平均粒径也可显著增加,而且其粒径分布也明显变宽。但是当阴离子杂质为单价的NO_3^-或Br^-时,对所制备的MH的粒径却没有明显的影响。 | 闫红旭 徐梓淮 Nafiu Sadi Bature 刘云义 范天博 郭洪范 | 2019 | 当代化工2019，48，3： | 2 |
| 8 | Clinical utility of serum cys- tatin C in predicting coronary artery disease 显示文摘 | Koc M Batur MK Karaarslan O | 2010 | Cardiol J2010，17，4： | 1 |
| 9 | Multiple part- type scheduling in flexible robotic cells 显示文摘 | Batur D G Karasan O E Akturk M S | 2012 | International Journal of Production Economics2012，135，2： | 1 |
| 10 | Clinical utility of serum cystatin C in predicting coronary artery disease 显示文摘 | Koc M Batur MK Karaarslan O | 2010 | Cardiol J2010，17，4： | 1 |
| 11 | Hopfield/ART-1 neural network-based fault detection and isolation 显示文摘 | Srinivasan A Batur C | 1994 | IEEE Trans Neural Networks1994，5，6： | 1 |
| 12 | Factors associated with functional disability in patients with rheumatoid arthritis 显示文摘 | Olden O Batur G Gfindtiz R | 2008 | Rheumatol Int2008，29，2： | 1 |
| 13 | Hypertension and arrhythmia: blood pressure control and beyond显示文摘 | Yildirir A Batur MK Oto A | 2002 | Europace2002，4，2： | 1 |
| 14 | Live Donor Liver Transplantation for Acute Liver Failure显示文摘 | Murat Kilic Unal Aydin Aysin Noyan Cigdem Arikan Sema Aydogdu Murat Akyildiz Zeki Karasu Murat Zeytunlu Mehmet Alper Yucel Batur | 2007 | Transplantation2007，，4： | 1 |
| 15 | Effects of stroke localization on cardiac autonomic balance and sudden death 显示文摘 | Tokgozoglu SL Batur MK Topcuoglu MA | 1999 | Stroke1999，30，： | 1 |
| 16 | Effects of stroke localization on cardiac autonomic balance and sudden death显示文摘 | Tokgozoglu SL Batur MK Topcuoglu MA | 1999 | Stroke1999，30，： | 1 |
| 17 | Interventional therapy in resistant hypertension; new renal denervation applications in Turkey显示文摘 | Dagdelen S Batur MK | 2012 | Anadolu Kardiyol Derg2012，12，2： | 1 |
| 18 | Recurrent transient ischemic attacks in a patients with POEMS syndrome显示文摘 | Akyol A Nazliel B Batur Caglayan HZ | 2014 | Case Rep Neurol Med2014，2014，15： | 1 |
| 19 | Syringocystadenocarcinoma papilliferum with squamous cell carcinoma differentiation and with locoregional naetastasis 显示文摘 | Arslan H Diyarbakrl M Batur S | 2013 | J Craniofac Surg2013，24，1： | 1 |
| 20 | Anodization of titanium alloys for orthopedic applications显示文摘In recent years, nanostructured oxide films on titanium alloy surfaces have gained significant interest due to their electrical, catalytic and biological properties. In literature, there is variety of different approaches to fabricate nanostructured oxide films. Among these methods, anodization technique, which allows fine-tuning of oxide film thickness, feature size, topography and chemistry, is one of the most popular approaches to fabricate nanostructured oxide films on titanium alloys, and it has been widely investigated for orthopedic applications. Briefly, anodization is the growth of a controlled oxide film on a metallic component attached to the anode of an electrochemical cell. This review provides an overview of the anodization technique to grow nanostmctured oxide films on titanium and titanium alloys and summarizes the interactions between anodized titanium alloy surfaces with cells in terms of cellular adhesion, proliferation and differentiation. It will start with summarizing the mechanism of nanofeatured oxide fabrication on titanium alloys and then switch its focus on the latest findings for anodization of titanium alloys, including the use of fluoride free electrolytes and anodization of 3D titanium foams. The review will also highlight areas requiring further research to successfully translate anodized titanium alloys to clinics for orthopedic applications. | Merve Izmir Batur Ercan | 2019 | Frontiers of Chemical Science and Engineering2019，13，1： | 1 |
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