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| 1 | Mindin is upregulated during colitis and may activate NF-κB in a TLR-9 mediated manner显示文摘AIM:To investigate the regulation of mindin expression and the signaling pathway involved during inflammation.METHODS:C57BL/6 mice were treated with 3% dextran sulfate sodium (DSS) in drinking water for 6 d to induce acute colitis,and then the colon was harvested for histological analysis or for RNA isolation.mRNA expression of mindin and nuclear factor (NF)-κB p65 was analyzed by quantitative real time polymerase chain reaction (RT-PCR) and mindin expression construct was conf irmed by Western blotting.Mouse macrophage and intestinal epithelial lineage cells were stimulated with different cytokines and toll-like receptor (TLR) ligands,before pNF-κB-luciferase activity was assessed using the Dual-Luciferase reporter assay system.RESULTS:mRNA expression of mindin was upregulated 4.7 ± 1.1 fold compared with the baseline during DSS-induced intestinal inflammation in the mice.Stimulation with CpG-ODN (a known TLR-9 ligand) induced 4.2 ± 0.3 fold upregulation of mindin expression in RAW 264.7 cells.Full-length of mindin was cloned from cDNA of mouse mesenteric lymph node,then the pCMV-Mindin-Flag expression vector was established and the protein expression level was confi rmed.Transfection of the mindin construct and stimulation with CpG-ODN signifi cantly increased the NF-κB-luciferase activity by 2.5 ± 0.3 and 4.5 ± 0.5 fold in RAW264.7 and CMT93 cells,respectively (P < 0.01).CONCLUSION:Mindin expression is upregulated during intestinal inflammation and may induce NF-κB promoter activation in a TLR-9 mediated manner. | Bayasi Guleng | 2010 | World Journal of Gastroenterology2010，16，9： | 3 |
| 2 | Cancer-derived VEGF plays no role in malignant ascites formation in the mouse显示文摘AIM: Vascular endothelial growth factor (VEGF) is a potent mediator of peritoneal fluid accumulation following tumor progression. This study investigated the role of VEGF secreted by cancerous cells in the formation of malignant ascites.METHODS: VEGF expression was eliminated byknockdown in the pancreas cancer cell-line PancO2 using vector-based short-hairpin type RNA interference (RNAi).Malignant ascites formation in the mouse was analyzed by intraperitoneal injection of PancO2 cells expressing VEGF or with expression knockdown.RESULTS: The VEGF knockdown PancO2 cell was successfully established. Knockdown of VEGF did not affect cancer cell proliferation in vitro or in vivo. The volume of ascites following peritoneal expansion of the tumor in VEGF knockdown cells and control cells did not differ statistically in this in vivo study. Moreover, the VEGF concentration in the ascites did not differ statistically.CONCLUSION: Malignant ascites formation might be mediated by VEGF production in noncancerous tissues,such as stromal compartments. An anti-VEGF strategy against malignant ascites could be applied to various tumors regardless of whether they secrete VEGF. | Bayasi Guleng Keisuke Tateishi Fumihiko Kanai Amarsanaa Jazag Miki Ohta Yoshinari Asaoka Hideaki Ijichi Yasuo Tanaka Jun Imamura Tsuneo Ikenoue Yasushi Fukushima Keita-Morikane Makoto Miyagishi Kazunari Taira Takao Kawabe Masao Omata | 2005 | World Journal of Gastroenterology2005，11，35： | 2 |
| 3 | Properties of polypropylene fiber reinforced concrete显示文摘 | Ziad Bayasi Jack Zeng | 1993 | ACI Material Journal1993，90，6： | 2 |
| 4 | Artifi cial liver support system in treatment of liverfailure after acute poisoning显示文摘BACKGROUND: Acute poisoning (AP) may cause failure of the liver and kidney, and evendeath. This study aimed to investigate the efficacy of artificial liver support system (ALSS) on thetreatment of liver failure after acute poisoning.METHODS: A total of 31 patients with liver failure caused by AP were admitted to emergency ICU,central ICU, and Department of Gastroenterology from 2005 to 2009 in Zhongshan Hospital Affi liatedto Xiamen University, China. Among them, 13 patients served as a treatment group, and used ALSS inaddition to detoxifi cation treatment and protective treatment of liver function, and the other 18 patientsserved as a control group receiving detoxifi cation treatment and protective treatment of liver function.RESULTS: In the treatment group, 10 patients (76.9%) were cured or improved, 2 died, and1 was discharged against advice. In the 18 patients in the control group, 7 (38.9%) were cured orimproved, 3 died, and 8 were discharged against advice. There was a significant difference in therates of improvement between the two groups (P〈0.05).CONCLUSION: ALSS is a safe and effective clinical method for the treatment of acute toxicliver failure. | Li-gang Chen Bayasi Guleng Jian-lin Ren Jian-min Chen Lin Wang | 2011 | World Journal of Emergency Medicine2011，2，4： | 2 |
| 5 | Chloride permeability and impact resistance of polypropylene-fiber-reinforced silica fume concrete 显示文摘 | TOUTANJI H MCNEIL S BAYASI Z | 1998 | Cem Concr Res1998，28，7： | 1 |
| 6 | Reduction of lateral reinforcement in seismic beam-column connection via application of steel fibers显示文摘 | Bayasi Z Gebman M | 2002 | ACI Structural Journal2002，99，6： | 1 |
| 7 | Application of fibrillated polypropylene fibres for restraint of plastic shrinkage cracking in silica fume concrete 显示文摘 | BAYASI Z MCINTYRE M | 2002 | ACI Materials Journal2002，99，4： | 1 |
| 8 | Chloride permeability and impact resistance of polypropylene-fiber reinforced silica fume concrete显示文摘 | TOUTANJI H MCNEIL S BAYASI Z | 1998 | CCR1998，28，7： | 1 |
| 9 | Reduction of lateral reinforcement in seismic beam-column connection via application of steel fibers 显示文摘 | Bayasi Z Gebman M | 2002 | ACI Structure Journal2002，99，6： | 1 |
| 10 | Composite slabs with corrugated SIMCON deck as alternative for corrugated metal sheets 显示文摘 | Bayasi Z Kaiser H Gonzales M | 2001 | Journal of Structural Engineering2001，127，10： | 1 |
| 11 | Properties of polypropylene fiber reinforced concrete显示文摘 | Bayasi Z Zeng J | 1993 | ACI Materials Journal1993，90，6： | 1 |
| 12 | Fiber-type effects on the performance of steel fiber reinforced concrete显示文摘 | BAYASI Z | 1991 | ACI Meterials Journal1991，88，2： | 1 |
| 13 | Fiber Type Effects on the Performance of Steel Fiber Reinforced Concrete 显示文摘 | Soroushian P Bayasi Z | 1991 | ACI Materials Journal1991，88，2： | 1 |
| 14 | Properties of polypropylene fiber reinforced concrete 显示文摘 | BAYASI Z ZENG J | 1993 | ACI Materials Journal1993，90，6： | 1 |
| 15 | Composite slabs with corrugated SIMCON deck as alterna- tive for corrugated metal sheets 显示文摘 | Bayasi Z Kaiser H Gonzales M | 2007 | Journal of Structural Engineering2007，127，10： | 1 |
| 16 | Effect of curing procedures on properties of silica fume concrete 显示文摘 | TOUTANJI H A BAYASI Z | 1999 | Cement and Concrete Research1999，29，4： | 1 |
| 17 | Effect of manufacturing techniques on the flexural behavior of steel fiber-reinforced concrete 显示文摘 | TOUTANJI H BAYASI Z | 1998 | Cement and Concrete Research1998，28，1： | 1 |
| 18 | Circulatory Antigen Processing by Mucosal Dendritic Cells Controls CD8 + T Cell Activation显示文摘 | Sun-Young Chang Joo-Hye Song Bayasi Guleng Carmen Alonso Cotoner Seiji Arihiro Yun Zhao Hao-Sen Chiang Michael O’Keeffe Gongxian Liao Christopher L. Karp Mi-Na Kweon Arlene H. Sharpe Atul Bhan Cox Terhorst Hans-Christian Reinecker | 2013 | Immunity2013，，： | 1 |
| 19 | Fiber type effects on the per formance of steel fiber reinforced concrete显示文摘 | SOROUSH1ANP BAYASI Z | 1991 | AC1 Materials Journal1991，88，2： | 1 |
| 20 | Chloride Permeabil- ity and Impact Resistance of Polypropylene-fiber-rein- forced Silica fume Concret显示文摘 | Toutanji H McNeil S Bayasi Z | 1998 | Cement and Concrete Re- search1998，28，7： | 1 |
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