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182篇 您的检索式:作者名="Baylin B"
    题名 作者 年代 出处 被引量
1Cancer epigenetics: linking basic biology to clinical medicine显示文摘癌症进化根本,阶段被 epigenetic 畸形以及基因改变驾驶。epigenetic 控制事件的 Dysregulation 可以导致 DNA methylation 和染色质配置的反常模式,哪个是到癌症的致病的批评贡献者。这些 epigenetic 畸形被在他们的单个部件之间的多重蛋白质建筑群和相互影响包括 DNA methylation 机械放并且坚持说, histone 修饰词,特别地 polycomb (PcG ) 蛋白质,和染色质改变蛋白质。在染色体宽的技术的最近的进展表明了这些 dysregulated epigenetic 部件的参与看起来广泛。而且,作为为癌症的一个驱动力有关像茎的房间 subpopulations 在在癌症和概念的 epigenetic 畸形之间有一个成长连接。新兴的数据建议对正常胚胎、成年的干细胞固有的 epigenetic 风景的方面可以帮助促进在长期的发炎或积累的反应的氧种类的压力下面,恶意的 subpopulations 的进化。最后,理解在癌症的所有类型涉及 epigenetic 畸形的开始和维护的分子的机制为翻译目的有大潜力。这为 epigenetic biomarker 开发已经是明显的,并且为指向的药理学瞄准颠倒癌症特定的 epigenetic 改变。Hsing-Chen Tsai Stephen B Baylin 2011Cell Research2011,21,3:18
2DNA hypermethylation in tumorigenesis:epigenetics joins genetics显示文摘Baylin S B Herman J G 0,,04:1
3Hypermethylation of the 5'region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies 显示文摘Baylin SB Fearon ER Vogelstein B 1987Blood1987,70,:1
4DNA hypermethylation in tumorigenesis: epigenetics joins genetics 显示文摘Baylin S B Herman J G 2000Trend Genet2000,16,4:1
5Expression of CD44 in human lung tumors显示文摘Penno M B August J T Baylin S B 1994CancerRes1994,54,5:1
6A gene hypermethylation profile of human cancer 显示文摘Esteller M Corn P G Baylin S B 2001Cancer Res2001,61,8:1
7The fundamental role of epigenetic events in cancer显示文摘JONES P A BAYLIN S B 2002Nat Rev Genet2002,3,6:1
8Gene silencing in cancer in assortatton with promoter hypermethylatian显示文摘HERMAN J G BAYLIN S B 2003N Engl J Med2003,349,:1
9Hypermethylation of the 5′ region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies显示文摘Baylin SB Fearon ER Vogelstein B 1987Blood1987,70,:1
10The epigenomies of cancer显示文摘P A Jones S B Baylin 2007Cell2007,128,4:1
11DNA hypermothylatian in tumorigenesis显示文摘Baylin S B Herman J G 2000TIG2000,16,4:1
12p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing显示文摘Cameron E E Baylin S B Herman J G 1999Blood1999,94,7:1
13Stress and the epigenetic landscape:a link to the pathobiology of human diseases? 显示文摘Johnstone SE Baylin B 2010Nat Rev Genet2010,11,:1
14The fundamental role of epigenetic events in cancer显示文摘Jones P A Baylin S B 0,,08:1
15A gene hypermethylation profile of human cancer显示文摘ESTELLER M CORN P G BAYLIN S B 2001Cancer Res2001,61,:1
16Protein kinase C-beta 2 inhibits cycling and decreases c-myc-induced apoptosis in small cell lung cancer cells显示文摘Barr L F Campbell S E Baylin S B 1997Cell Growth Differ1997,8,4:1
17A gene hypermethylation profile of human cancer显示文摘Esteller M Corn P G Baylin S B 2001Cancer Res2001,61,8:1
18The fundamental role of epige- netic events in cancer显示文摘Jones P A Baylin S B 2002Nat Rev Genet2002,3,6:1
19Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors显示文摘Ball D W Azzoli C G Baylin S B 1993Proc Natl Acad Sci USA1993,90,12:1
20Gene silencing in cancer in association with promoter hypermethylation 显示文摘Herman J G Baylin S B 2003N Engl J Med2003,349,21:1
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