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| 1 | Rapid and efficient reprogramming of human fetal and adult blood CD34~ cells into mesenchymal stem cells with a single factor显示文摘进体的干细胞的皮房间的直接变换在再生药打开了新治疗学的可能性。这里,我们证明人的导致的间充质的干细胞(iMSCs ) 能高效地从绳索血(CB ) 被产生 - 或由有一个单个因素的直接 reprogramming 的成年的外部血(PB )-CD34+ 房间, OCT4。面对一个 GSK3 禁止者, 16% OCT4-transduced CD34 + 房间在 2 个星期以内被变换成 iMSCs。有效直接 reprogramming 与两 episomal 被完成调停向量的短暂 OCT4 表示和 lentiviral 调停向量的 OCT4 transduction。iMSCs 快车 MSC 标记,类似于骨头髓(BM ) 在形态学的 -MSCs,并且在 vitro multilineage 区别能力拥有,还与 BM-MSCs 相比有一个更大的 proliferative 能力。类似于 BM-MSCs,植入的 iMSCs 形式骨头和结缔组织,并且是在老鼠的 non-tumorigenic。然而, BM-MSCs 不而 iMSCs 确实形成肌肉纤维,显示 iMSCs 的一个潜在的功能的优点。另外,我们观察到 OCT4 表示的高水平为起始的 reprogramming 和最佳的 iMSC 自强被要求,当 OCT4 表示的减小为 multilineage 区别被要求时。我们的方法将贡献病人特定的 iMSCs 的产生,它能在再生药有应用。这发现可以也为血房间的直接变换便于策略的发展进临床的重要性的房间的另外的类型。 | Xianmei Meng Rui-Jun Su David J Baylink Amanda Neises Jason B Kiroyan Wayne Yuk-Wai Lee Kimberly J Payne Daila S Gridley Jun Wang K-H William Lau Gang Li Xiao-Bing Zhang | 2013 | Cell Research2013，23，5： | 2 |
| 2 | Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways 显示文摘 | Kapur S Baylink D J Lau KH | 2003 | Bone2003，32，3： | 1 |
| 3 | Skeletal alkaline phosphatase ac- tivity in serum显示文摘 | Farley J Baylink D J | 1995 | Clinical chemistry1995，41，11： | 1 |
| 4 | Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways显示文摘 | Kapur S Baylink D J Lau K H | 2003 | Bone2003，32，3： | 1 |
| 5 | Structure-function analysis of the human insulin-like growth factor binding protein-4显示文摘 | Qin X Strong D D Baylink D J | 1998 | J Biol Chem1998，273，23： | 1 |
| 6 | Incidence of hip fractures in osteoporotic women treated with sodium fluoride显示文摘 | Riggs BL Baylink D J Kleerekoper M | 1987 | J Bone Miner Res1987，2，： | 1 |
| 7 | Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanisms显示文摘 | Mohan S Richman C Guo R Amaar Y Donahue LR Wergedal J Baylink DJ | | 0，，： | 1 |
| 8 | Expression of a structurally unique osteoclastic protein-tyrosine phosphatase is driv- en by an alternative intronic, cell type-specific promoter显示文摘 | Amoui M Baylink D J Tillman J B Lau K H | 2003 | J Bi- ol Chem2003，278，44： | 1 |
| 9 | Skeletal alkaline phosphatase activity in serum显示文摘 | Farley J Baylink DJ | 1995 | Clin Chem1995，41，11： | 1 |
| 10 | Growth factors to srimulate bone formation显示文摘 | Baylink J Finkelman RD Mohan S | 1993 | J Bone Miner Res1993，8，2： | 1 |
| 11 | Skeletal alkaline phosphatase activity inserum 显示文摘 | FARLEY J BAYLINK D J | 1995 | Clin Chem1995，41，11： | 1 |
| 12 | Recombinant Human Insulin-like Growth Factor-binding Protein-5 Stimulates Bone Formation Parameters in Vitro and in Vivo显示文摘 | Richman C Baylink D J Lang K | 1999 | Endocrinology1999，140，10： | 1 |
| 13 | Insulin-like growth factor binding proteins in serum and other biology fluids:regulation and functions显示文摘 | Rajaram S Baylink D J Mohan S | 1997 | Endocr Rev1997，67，9： | 1 |
| 14 | Fluoride directly stimulates proliferation and alkaline phosphatase activity of boneforming cells显示文摘 | Farley J R Wergedal J E Baylink D J | 1983 | Science1983，227，： | 1 |
| 15 | Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways显示文摘 | KAPUR S BAYLINK D J LAU K H | 2003 | Bone2003，32，： | 1 |
| 16 | Inhibition of bone formation during space flight显示文摘 | MOREY E R BAYLINK D J | 1978 | Science1978，201，4361： | 1 |
| 17 | Skeletal alkaline phosphatase activity in serum 显示文摘 | Farley J Baylink DJ | 1995 | Clin Chem1995，41，11： | 1 |
| 18 | Growth factors to stimulate bone formation显示文摘 | Baylink D J Finkelman RD Mohan S | 1993 | J Bone Miner Res1993，8，2： | 1 |
| 19 | Fluid shear stress synergizes with insulin-like growth factor-I(IGF-I)on osteoblast proliferation through integrin-dependent activation of IGF-I mitogenic signaling pathway 显示文摘 | Kapur S Mohan S Baylink D J | 2005 | J Biol Chem2005，280，20： | 1 |
| 20 | Growth factors to stimulate bone formation显示文摘 | BAYLINK D J FINKELMAN R D MOHAN S | 1993 | J Bone Miner Res1993，8，： | 1 |
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