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5篇 您的检索式：作者名="Beat Ernst"

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		题名	作者	年代	出处	被引量
	1	Metabolism of dichloromethane (methylene chloride) to formaldehyde in human erythrocytes: influence of polymorphism of glutathione transferase Theta (GST T1-1)显示文摘	Ernst Hallier Klaus R. Schr?der Karin Asmuth Anja Dommermuth Beate Aust Hans Werner Goergens	1994	Archives of Toxicology1994，，7：	1
	2	Evalution of parameters seterminating the performance of electrochromatography in packed capillary columns显示文摘	Behnke Beate Grom Edgar Bayer Ernst	1995	J Chromatography A1995，716，：	1
	3	Mercury, cadmium and lead concentrations in different ecophysiological groups of earthworms in forest soils显示文摘	Gregor Ernst Stefan Zimmermann Peter Christie Beat Frey	2008	Environmental Pollution2008，，3：	1
	4	The diffu- sion of deterrents into propellants observed by FTIR microspectro- pscopy-quantification of the diffusion process显示文摘	Beat Vogelsanger Bruno Ossola Ernst Bronnimann	1996	Propellants Ex- plosive Pyrotechnic1996，21，6：	1
	5	E-selectin ligand complexes adopt an extended high-affinity conformation显示文摘E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early inflammatory response by binding to glycoproteins containing the tetrasaccharide sialyl Lewisx(sLex).Efficient leukocyte recruitment under vascular flow conditions depends on an increased lifetime of E-selectin/ligand complexes under tensile force in a so-called catch-bond binding mode.Co-crystal structures of a representative fragment of the extracellular E-selectin region with sLex and a glycomimetic antagonist thereof reveal an extended E-selectin conformation,which is identified as a high-affinity binding state of E-selectin by molecular dynamics simulations.Small-angle X-ray scattering experiments demonstrate a direct link between ligand binding and E-selectin conformational transition under static conditions in solution.This permits tracing a series of concerted structural changes connecting ligand binding to conformational stretching as the structural basis of E-selectin catch-bond-mediated leukocyte recruitment.The detailed molecular view of the binding site paves the way for the design of a new generation of selectin antagonists.This is of special interest,since their therapeutic potentialwas recently demonstrated with the pan-selectin antagonists GMI-1070(Rivipansel).	Roland C.Preston Roman P.Jakob Florian P.C.Binder Christoph P.Sager Beat Ernst Timm Maier	2016	Journal of Molecular Cell Biology2016，8，1：	0

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