|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin显示文摘The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal hyperplasia.Similarly,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the skin.However,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains unknown.Here,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T cells.This activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/LFA-1.Naive T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 cells.In particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/CD2.The latter molecule initiated STAT1 signaling and IFN γproduction in T cells.Costimulation of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin disease.Consequently,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases. | Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag | 2020 | Cellular & Molecular Immunology2020，17，4： | 4 |
| 2 | Activation ofperoxisome proliferator--activated receptor-alpha protects the heart from ischemia/reperfusion injury显示文摘 | Yue TL Bao WK Beat J | 2003 | Circulation2003，108，19： | 1 |
| 3 | Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging显示文摘 | Hannes G. Kenngott Martin Wagner Matthias Gondan Felix Nickel Marco Nolden Andreas Fetzer Jürgen Weitz Lars Fischer Stefanie Speidel Hans-Peter Meinzer Dittmar B?ckler Markus W. Büchler Beat P. Müller-Stich | 2014 | Surgical Endoscopy2014，，3： | 1 |
| 4 | Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ 显示文摘 | TRAYHURN P BEAT'FIE J | 2001 | Proc Nutr Soc2001，60，： | 1 |
| 5 | Phenotypic characterization of skin lesions in urticaria pigmentosa and mastocytomas显示文摘 | Norbert Haas Kathrin Hamann Jürgen Grabbe Bernd Algermissen Beate M. Czarnetzki | 1995 | Archives of Dermatological Research (-)1995，，3： | 1 |
| 6 | The predictive value of metabolic response to preoperative radiochemotherapy in locally advanced rectal cancer measured by PET/CT显示文摘 | Robert Rosenberg Ken Herrmann Ralf Gertler Beat Künzli Markus Essler Florian Lordick Karen Becker Tibor Schuster Hans Geinitz Matthias Maak Markus Schwaiger J?rg-Rüdiger Siewert Bernd Krause | 2009 | International Journal of Colorectal Disease2009，，2： | 1 |
| 7 | The effects of disseminated meth- ane hydrate on the dynamic stiffness and damping of a sand 显示文摘 | Clayton C Priest J Beat A | 2005 | Geotechnique2005，55，6： | 1 |
| 8 | Evaluation of nun - formalin tissue fixation for molecular profiling studies 显示文摘 | Gillespie J W Beat C M Biehsel V E | 2002 | Am J Pathol2002，160，2： | 1 |
| 9 | Exploration of stress-induced immuno suppresion in chickens reveals both stress-resistant and stress-susceptible antigen responses显示文摘 | Heba E L Beat H E Thomas W J | 2003 | Veterinary Immunology and Immunopathology2003，95，： | 1 |
| 10 | Anal Chim Acta显示文摘 | Ariane Nimptsch Stephanie Schibur Matthias Schnabelrauch Beate Fuchs Daniel Huster Jürgen Schiller | 2009 | 635:1752009，635，： | 1 |
| 11 | The predictive value of metabolic response to preoperative radiochemotherapy in locally advanced rectal cancer measured by PET/CT显示文摘 | Robert Rosenberg Ken Herrmann Ralf Gertler Beat Künzli Markus Essler Florian Lordick Karen Becker Tibor Schuster Hans Geinitz Matthias Maak Markus Schwaiger J?rg-Rüdiger Siewert Bernd Krause | 2009 | International Journal of Colorectal Disease2009，，： | 1 |
| 12 | Gender identity and material symbols:Objects and decision considerations in impulse purchases显示文摘 | Dittmar H Beat tie J and Friese S | 1995 | Journal of Economic Psychology1995，16，3： | 1 |
| 13 | Experi- mental verification of the fracture density and shear-wave splitting relationship using synthetic silica cemented sand- stones with a controlled fracture geometry 显示文摘 | TILLOTSON P SOTHCOT1 J BEAT A I | 2012 | Geophysical prospecting2012，60，3： | 1 |
| 14 | Expression of luciferase in selected organs following delivery of naked and formulated DNA to rainbow trout(Oncorhynchus mykiss) by different routes of administration显示文摘 | Kristine R Beate J T Oystein E | 2004 | Fish & Shellfish Immunology2004，16，： | 1 |
| 15 | Insiturheological investigation of the coagulation aqueous alumina suspensions 显示文摘 | Beate B Martink M H Ludwig J G | 2001 | Am Ceram Sac2001，84，8： | 1 |
| 16 | 注意力缺陷/多动症和儿童期自闭症与产前暴露于全氟烷基物质之间的关联:丹麦全国出生队列的一项巢式病例对照研究显示文摘[背景]全氟烷基物质(PFASs)是持久性污染物,动物实验中具有内分泌干扰性和神经毒性。一些横断面数据显示PFASs与儿童神经行为的问题之间存在正向关联,但是来自前瞻性研究的结果仍然有限。[目的]研究产前暴露于PFASs是否与儿童中的注意力缺陷/多动障碍(ADHD)或儿童期自闭症之间有关联。[方法]在1996—2002年丹麦全国出生队列的83 389对母子中,根据丹麦国家医院登记和丹麦精神病中心登记,确定了890名ADHD病例和301名儿童自闭症病例。从这个队列中,随机各选择220例多动症和自闭症病例,并随机选择550例性别相匹配的对照儿童。测量在妊娠早期或中期采集的母体血浆中16种PFASs,使用广义线性模型计算风险比(RRs),模型中考虑到了抽样权重。[结果]在所有样品中均检测到全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA),在≥90%的样本中可以定量其他4种PFASs。没有发现母亲PFAS血浆水平和ADHD之间关联的一致性证据[浓度(ng/m L)的自然对数值每增加一个单位,PFOS对应的RR=0.87(95%CI:0.74,1.02),PFOA对应的RR=0.98(95%CI:0.82,1.16)],对于自闭症也是如此[浓度(ng/m L)的自然对数每增加一个单位,PFOS对应的RR=0.92(95%CI:0.69,1.22),PFOA对应的RR=0.98(95%CI:0.73,1.31)]。在同时校正所有PFASs的模型中,较高的PFAS分位数和ADHD之间既有阳性关联也有阴性关联,但是这些关联的估计值并不精确。[结论]在这项研究中,没有发现一致性的证据能够提示产前PFAS暴露增加儿童中ADHD或儿童期自闭症儿的风险。 | Zeyan Liew Beate Ritz Ondine S.von Ehrenstein Bodil Hammer Bech Ellen Aagaard Nohr Chunyuan Fei Rossana Bossi Tine Brink Henriksen Eva Cecilie Bonefeld-Jφrgensen Jφrn Olsen | 2015 | 环境与职业医学2015，32，10： | 1 |
| 17 | Endoscopic posterior mesorectal resection as an option to combine local treatment of early stage rectal cancer with partial mesorectal lymphadenectomy显示文摘 | J?rg K?ninger Beat P. Müller-Stich Frank Autschbach Peter Kienle Jürgen Weitz Markus W. Büchler Carsten N. Gutt | 2007 | Langenbeck’s Archives of Surgery2007，，5： | 1 |
| 18 | Alveolar echinococcosis: From a deadly disease to a well-controlled infection. Relative survival and economic analysis in Switzerland over the last 35 years显示文摘 | Paul R. Torgerson Alexander Schweiger Peter Deplazes Maja Pohar Jürg Reichen Rudolf W. Ammann Philip E. Tarr Nerman Halkik Beat Müllhaupt | 2008 | Journal of Hepatology2008，，1： | 1 |
| 19 | Enhanced green fluorescent protein-transfection of murine colon carcinoma cells: Key for early tumor detection and quantification显示文摘 | J?rg W. Sturm Michael A. Keese Beate Petruch Roderich G. B?nninghoff Hongyue Zhang Norbert Gretz Mattias Hafner Stefan Post Robert S. Mc Cuskey | 2003 | Clinical and Experimental Metastasis2003，，5： | 1 |
| 20 | Magnesium deficiency treatment causes reductions in photosynthesis of well-nourished norway spruce显示文摘 | Beate M J | 1996 | Trees1996，10，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员