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| 1 | Radiofrequency ablation of liver tumors: Actual limitations and potential solutions in the future显示文摘Over the past decade,radiofrequency ablation(RFA) has evolved into an important therapeutical tool for the treatment of non resectable primary and secondary liver tumors.The clinical benefit of RFA is represented in several clinical studies.They underline the safety and feasibility of this new and modern concept in treating liver tumors.RFA has proven its clinical impact not only in hepatocellular carcinoma(HCC) but also in metastatic disease such as colorectal cancer(CRC).Due to the increasing number of HCC and CRC,RFA might play an even more important role in the future.Therefore,the refinement of RFA technology is as important as the evaluation of data of prospective randomized trials that will help define guidelines for good clinical practice in RFA application in the future.The combination of hepatic resection and RFA extends the feasibility of open surgical procedures in patients with extensive tumors.Adverse effects of RFA such as biliary tract damage,liver failure and local recurrence remain an important task today but overall the long term results of RFA application in treating liver tumors are promising.Incomplete ablation of liver tumors due to insufficient technology of ablation needles,tissue cooling by the neighbouring blood vessels,large tumor masses and ablation of tumors in close vicinity to heat sensitive organs remain difficult tasks for RFA.Future solutions to overcome these limitations of RFA will include refinement of ultrasonographic guidance(accuracy of probe placement),improvements in needle technology(e.g.needles preventing charring)and intraductal cooling techniques. | Beat M Künzli Paolo Abitabile Christoph A Maurer | 2011 | World Journal of Hepatology2011，3，1： | 15 |
| 2 | Liver resections can be performed safely without Pringle maneuver: A prospective study显示文摘AIM To evaluate liver resections without Pringle maneuver, i.e., clamping of the portal triad. METHODS Between 9/2002 and 7/2013, 175 consecutive liver resections(n = 101 major anatomical and n = 74 large atypical > 5 cm) without Pringle maneuver were performed in 127 patients(143 surgeries). Accompanying, 37 wedge resections(specimens < 5 cm) and 43 radiofrequency ablations were performed. Preoperative volumetric calculation of the liver remnant preceeded all anatomical resections. The liver parenchyma was dissected by waterjet. The median central venous pressure was 4 mmH g(range: 5-14). Data was collected prospectively. RESULTS The median age of patients was 60 years(range: 16-85). Preoperative chemotherapy was used in 70 cases(49.0%). Liver cirrhosis was present in 6.3%, and liver steatosis of ≥ 10% in 28.0%. Blood loss was median 400 mL(range 50-5000 mL). Perioperative blood transfusions were given in 22/143 procedures(15%). The median weight of anatomically resected liver specimens was 525 g(range: 51-1850 g). One patient died postoperatively. Biliary leakages(n = 5) were treated conservatively. Temporary liver failure occurred in two patients.CONCLUSION Major liver resections without Pringle maneuver are feasible and safe. The avoidance of liver inflow clamping might reduce liver damage and failure, and shorten the hospital stay. | Christoph A Maurer Mikolaj Walensi Samuel A Kaser Beat M Künzli Rene Lotscher Anne Zuse | 2016 | World Journal of Hepatology2016，8，24： | 6 |
| 3 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 4 | Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin显示文摘The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal hyperplasia.Similarly,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the skin.However,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains unknown.Here,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T cells.This activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/LFA-1.Naive T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 cells.In particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/CD2.The latter molecule initiated STAT1 signaling and IFN γproduction in T cells.Costimulation of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin disease.Consequently,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases. | Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag | 2020 | Cellular & Molecular Immunology2020，17，4： | 4 |
| 5 | A systematic review and meta-analysis of laparoscopic versus open distal pancreatectomy for benign and malignant lesions of the pancreas: It’s time to randomize显示文摘 | Arianeb Mehrabi Mohammadreza Hafezi Jalal Arvin Majid Esmaeilzadeh Camelia Garoussi Golnaz Emami Julia K?ssler-Ebs Beat Peter Müller-Stich Markus W. Büchler Thilo Hackert Markus K. Diener | 2014 | Surgery2014，，： | 4 |
| 6 | Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial显示文摘 | John Willy Haukeland Zbigniew Konopski Heidi Beate Eggesb? Hilde L?land von Volkmann Gabriele Raschpichler Kristian Bj?ro Terese Haaland Else Marit L?berg K?re Birkeland | 2009 | Scandinavian Journal of Gastroenterology2009，，7： | 3 |
| 7 | Is laparoscopic colorectal cancer surgery equal to open surgery? An evidence based perspective显示文摘Laparoscopic colorectal surgery(LCS) is an evolving subject.Recent studies show that LCS can not only offer safe surgery but evidence is growing that this new technique can be superior to classical open procedures.Fewer perioperative complications and faster postoperative recovery are regularly mentioned when studies of LCS are presented.Even though the learning curve of LCS is frequently debated when limitations of laparoscopic surgeries are reviewed,studies show that in experienced hands LCS can be a safe procedure for colorectal cancer treatment.The learning curve however,is associated with high conversion rates and economical aspects such as higher costs and prolonged hospital stay.Nevertheless,laparoscopic colorectal cancer surgery(LCCR) offers several advantages such as less co-morbidity and less postoperative pain in comparison with open procedures.Furthermore,the good exposure of the pelvic cavity by laparoscopy and the magnification of anatomical structures seem to facilitate pelvic dissection laparoscopically.Moreover,recent studies describe no difference in safety and oncological radicalness in LCCR compared to the open total mesorectal excision(TME).The oncological adequacy of LCCR still remains unproven today,because long-term results do not yet exist.To date,only a few studies have described the results of laparoscopic TME combined with preoperative adjuvant treatment for colorectal cancer.The aim of this review is to examine the various areas of development and controversy of LCCR in comparison to the conventional open approach. | Beat M Künzli Helmut Friess Shailesh V Shrikhande | 2010 | World Journal of Gastrointestinal Surgery2010，2，4： | 3 |
| 8 | Impact of land use changes on water dynamics-a case study in temperate meso and macroscale river basins显示文摘 | Beate K and Haberlandt U | 2002 | Physics and Chemistry of the Earth2002，27，： | 1 |
| 9 | Ceftiofur Sodium Monoclonal antibody development and cross - reactivity studies with structurally related cephalosporins显示文摘 | Beate G R Sandra A B Carol K H | 1996 | J Agric Food Chem1996，44，： | 1 |
| 10 | Rosiglitazone improves glomerular hyperfihration,renal endothelial dysfunction,and microalbuminuria of incipient diabetic nephlopathy in patients显示文摘 | Frank P Kay H Beate K | 2005 | Diabetes2005，54，7： | 1 |
| 11 | Specific bacterial, archaeal, and eukaryotic communities in tidal-flat sediments along a vertical profile of several meters显示文摘 | Reinhard W Henrik S Beate K | 2006 | Applied and Environmental Microbiology2006，72，4： | 1 |
| 12 | The predictive value of metabolic response to preoperative radiochemotherapy in locally advanced rectal cancer measured by PET/CT显示文摘 | Robert Rosenberg Ken Herrmann Ralf Gertler Beat Künzli Markus Essler Florian Lordick Karen Becker Tibor Schuster Hans Geinitz Matthias Maak Markus Schwaiger J?rg-Rüdiger Siewert Bernd Krause | 2009 | International Journal of Colorectal Disease2009，，2： | 1 |
| 13 | Specific Bacterial, Archaeal, and Eukaryotic Communities in Tidal - Flat Sediments along a Vertical Profile of Several Meters显示文摘 | Reinhard Wilms Henrik Sass Beate Kǒpke | 2006 | Applied and Environmental Microbiology2006，72，： | 1 |
| 14 | Ceftiofur sodium mono-clonal antibody development and cross reactivity studies withstructurally related cephalosporins显示文摘 | Beate G R Sandra A B Carol K H | 1996 | J Agric Food Chem1996，44，： | 1 |
| 15 | Effect of wetting and the presence of peanut tissues on germination of sclerotia of Sclerotium rolfsii produced in soil显示文摘 | BEATE M K RODRIGUEZ-KABANA R | 1979 | Phytopathology1979，89，： | 1 |
| 16 | Rigid double plate fixation for ankle arthrosis显示文摘 | Beat H Markus K | 2009 | Tech Foot Ankle Surg2009，8，： | 1 |
| 17 | Effect of wetting and the presence of peanut tissues on germination of selerotia of Sclerotium rolfsii produced in soil 显示文摘 | Beate M K Rodriguez-Kabana R | 1979 | Phytopathology1979，89，： | 1 |
| 18 | Rosiglitazone Improves Glomerular Hyperfihration, Renal Endothelial Dysfunction, and Microalbuminuria of Incipient Diabetic Nephlopathy in Patients 显示文摘 | Frank P Kay H Beate K | 2005 | Diabetes2005，54，7： | 1 |
| 19 | Reduced Coronary Dilatory Capacity and Ultrastructural Changes of the Myocardium in Patients with Angina Pectoris But Normal Coronary Arteriograms显示文摘 | DIETER OPHERK HORST ZEBE EBERHARD WEIHE GERHARD MALL Charlotte Dürr BEATE GRAVERT HELMUTH C. MEHMEL FRANZ SCHWARZ Wolfgang Kübler | 1981 | Circulation1981，，： | 1 |
| 20 | Rosiglitazone improves glomerular hyperfihration, renal endothelial dysfunction, and microalbuminuria of incipient diabetic nephlopathy in patients显示文摘 | FRANK P KAY H BEATE K | 2005 | Diabetes2005，54，7： | 1 |
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