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| 1 | 2010年世界胃肠病学组织关于炎症性肠病诊断和治疗的实践指南显示文摘炎症性肠病(IBD)是一组特发性、慢性、炎症性肠道疾病状态,包括两种主要类型:克罗恩病(CD)和溃疡性结肠炎(UC),两者的临床和病理特征既有重叠又有区别。IBD过去常见于发达国家,近几十年,发展中国家的患病率逐步上升。本指南就IBD诊断和治疗方面提出的独特议题在当前的文献和指南中几乎从未被提及。由于各地区的IBD临床特点差异较大,因此根据患者的主诉诊断IBD或评估疾病活动度需随地区的变化而变化。同样,治疗亦应根据疾病的分类和当地医疗资源进行调整。世界胃肠病学组织根据世界各国医疗资源的差异,采用级联方法制订了IBD的诊疗指南。 | Charles N.Bernstein Michael Fried J.H.Krabshuis Henry Cohen R.Eliakim Suleiman Fedail Richard Gearry K.L.Goh Saheed Hamid Aamir Ghafor Khan A.W.LeMair Malfertheiner Qin Ouyang J.F.Rey Ajit Sood Flavio Steinwurz Ole O.Thomsen Alan Thomson Gillian Watermeyer 杨钊斌 杨川华 钱本余 | 2010 | 胃肠病学2010，15，9： | 101 |
| 2 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 3 | Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrhea显示文摘AIM: To validate 4-sample lactose hydrogen breath testing(4SLHBT) compared to standard 13-sample LHBT in the clinical setting.METHODS: Irritable bowel syndrome patients with diarrhea(IBS-D) and healthy volunteers(HVs) were enrolled and received a 10 g, 20 g, or 40 g doselactose hydrogen breath test(LHBT) in a randomized, double-blinded, controlled trial. The lactase gene promoter region was sequenced. Breath samples and symptoms were acquired at baseline and every 15 min for 3 h(13 measurements). The detection rates of lactose malabsorption(LM) and lactose intolerance(LI) for a 4SLHBT that acquired four measurements at 0, 90, 120, and 180 min from the same data set were compared with the results of standard LHBT.RESULTS: Sixty IBS-D patients and 60 HVs were studied. The genotype in all participants was C/C-13910. LM and LI detection rates increased with lactose dose from 10 g, 20 g to 40 g in both groups(P < 0.001). 4SLHBT showed excellent diagnostic concordance with standard LHBT(97%-100%, Kappa 0.815-0.942) with high sensitivity(90%-100%) and specificity(100%) at all three lactose doses in both groups.CONCLUSION: Reducing the number of measurements from 13 to 4 samples did not significantly impact on the accuracy of LHBT in health and IBS-D. 4SLHBT is a valid test for assessment of LM and LI in clinical practice. | Jian-Feng Yang Mark Fox Hua Chu Xia Zheng Yan-Qin Long Daniel Pohl Michael Fried Ning Dai | 2015 | World Journal of Gastroenterology2015，21，24： | 4 |
| 4 | Silymarin Ascending Multiple Oral Dosing Phase I Study in Noncirrhotic Patients With Chronic Hepatitis C显示文摘 | Roy L. Hawke Sarah J. Schrieber Tedi A. Soule Zhiming Wen Philip C. Smith Rajender K. Reddy Abdus S. Wahed Steven H. Belle Nezam H. Afdhal Victor J. Navarro Josh Berman Qi-Ying Liu Edward Doo Michael W. Fried | 2010 | Journal of Clinical Pharmacology2010，，4： | 2 |
| 5 | Pneumatosis intestinalis显示文摘 | R. Michael Boerner MD PhD Daniel B. Fried MPH David M. Warshauer MD Dr. Kim Isaacs MD PhD | 1996 | Digestive Diseases and Sciences1996，，11： | 2 |
| 6 | Prevalence and Presentation of Lactose Intolerance and Effects on Dairy Product Intake in Healthy Subjects and Patients With Irritable Bowel Syndrome显示文摘 | Jianfeng Yang Yanyong Deng Hua Chu Yanqun Cong Jianmin Zhao Daniel Pohl Benjamin Misselwitz Michael Fried Ning Dai Mark Fox | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 7 | Maximizing Opportunities and Avoiding Mistakes in Triple Therapy for Hepatitis C Virus显示文摘 | A. Sidney Barritt Michael W. Fried | 2012 | Gastroenterology2012，，6： | 2 |
| 8 | Peroral Endoscopic Myotomy for the Treatment of Achalasia: An International Prospective Multicenter Study显示文摘 | Daniel Von Renteln Karl–Hermann Fuchs Paul Fockens Peter Bauerfeind Melina C. Vassiliou Yuki B. Werner Gerald Fried Wolfram Breithaupt Henriette Heinrich Albert J. Bredenoord Jan F. Kersten Tessa Verlaan Michael Trevisonno Thomas R?sch | 2013 | Gastroenterology2013，，2： | 2 |
| 9 | Peginterferon and Ribavirin Treatment in African American and Caucasian American Patients With Hepatitis C Genotype 1显示文摘 | Hari S. Conjeevaram Michael W. Fried Lennox J. Jeffers Norah A. Terrault Thelma E. Wiley–Lucas Nezam Afdhal Robert S. Brown Steven H. Belle Jay H. Hoofnagle David E. Kleiner Charles D. Howell | 2006 | Gastroenterology2006，，2： | 2 |
| 10 | Fibroblast Growth Factor 23, Bone Mineral Density, and Risk of Hip Fracture Among Older Adults: The Cardiovascular Health Study显示文摘 | Anna Jovanovich Petra Bù?ková Michel Chonchol John Robbins Howard A. Fink Ian H. de Boer Bryan Kestenbaum Ronit Katz Laura Carbone Jennifer Lee Gail A. Laughlin Kenneth J. Mukamal Linda F. Fried Michael G. Shlipak Joachim H. Ix | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，8： | 1 |
| 11 | Peginterferon alfa -2a plus ribavirin for chronic hepatitis C virus infection 显示文摘 | Michael W Fried MD Mitchell L | 2002 | N Engl J Med2002，347，： | 1 |
| 12 | Hepatocellular Carcinoma (HCC): A Global Perspective显示文摘 | Peter Ferenci Michael Fried Douglas Labrecque Jordi Bruix Morris Sherman Masao Omata Jenny Heathcote Teehra Piratsivuth Mike Kew Jesse A. Otegbayo S.S. Zheng S. Sarin Saeed S. Hamid Salma Barakat Modawi Wolfgang Fleig Suliman Fedail Alan Thomson Aamir Kha | 2010 | Journal of Clinical Gastroenterology2010，，4： | 1 |
| 13 | Rapid analysis of sugars in fruit juices by FT-NIR spectroscopy显示文摘 | Luis E. Rodriguez-Saona Fredrick S. Fry Michael A. McLaughlin Elizabeth M. Calvey | 2001 | Carbohydrate Research2001，，1： | 1 |
| 14 | Hepatitis C virus treatment in the real world: optimising treatment and access to therapies显示文摘 | Zoulim Fabien Liang T Jake Gerbes Alexander L Aghemo Alessio Deuffic-Burban Sylvie Dusheiko Geoffrey Fried Michael W Pol Stanislas Rockstroh Ju?rgen Kurt Terrault Norah A Wiktor Stefan | 2015 | Gut2015，，11： | 1 |
| 15 | Variables separated equations:Strikingly different roles for the Branch Cycle Lemma and the finite simple group classification显示文摘Davenport's Problem asks:What can we expect of two polynomials,over Z,with the same ranges on almost all residue class fields? This stood out among many separated variable problems posed by Davenport,Lewis and Schinzel.By bounding the degrees,but expanding the maps and variables in Davenport's Problem,Galois stratification enhanced the separated variable theme,solving an Ax and Kochen problem from their Artin Conjecture work.Denef and Loeser applied this to add Chow motive coefficients to previously introduced zeta functions on a diophantine statement.By restricting the variables,but leaving the degrees unbounded,we found the striking distinction between Davenport's problem over Q,solved by applying the Branch Cycle Lemma,and its generalization over any number field,solved by using the simple group classification.This encouraged Thompson to formulate the genus 0 problem on rational function monodromy groups.Guralnick and Thompson led its solution in stages.We look at two developments since the solution of Davenport's problem.Stemming from MacCluer's 1967 thesis,identifying a general class of problems,including Davenport's,as monodromy precise.R(iemann)E(xistence)T(heorem)'s role as a converse to problems generalizing Davenport's,and Schinzel's (on reducibility).We use these to consider:Going beyond the simple group classification to handle imprimitive groups,and what is the role of covers and correspondences in going from algebraic equations to zeta functions with Chow motive coefficients. | FRIED Michael D. | 2012 | Science China Mathematics2012，55，1： | 1 |
| 16 | Relationship of Uric Acid With Progression of Kidney Disease显示文摘 | Michel Chonchol Michael G. Shlipak Ronit Katz Mark J. Sarnak Anne B. Newman David S. Siscovick Bryan Kestenbaum Jan Kirk Carney Linda F. Fried | 2007 | American Journal of Kidney Diseases2007，，2： | 1 |
| 17 | Rapid virological response is the most important predictor of sustained virological response across genotypes in patients with chronic hepatitis C virus infection显示文摘 | Michael W. Fried Stephanos J. Hadziyannis Mitchell L. Shiffman Diethelm Messinger Stefan Zeuzem | 2011 | Journal of Hepatology2011，，1： | 1 |
| 18 | Should Science be Taught in Early Childhood?显示文摘 | Haim Eshach Michael N. Fried | 2005 | Journal of Science Education and Technology2005，，3： | 1 |
| 19 | Referencestrand-mediated conformation analysis of MHC alleles: a new method for high-resolution typing of the Ovar-DQB genes 显示文摘 | Petra Feichtlbauer-Huber Michael J Stear Ruedi Fries | 2000 | Immunogenetics2000，51，： | 1 |
| 20 | Efficacy and safety of pegylated (40-kd) interferon α-2a compared with interferon α-2a in noncirrhotic patients with chronic hepatitis C显示文摘 | K.Rajender Reddy Teresa L. Wright Paul J. Pockros Mitchell Shiffman Gregory Everson Robert Reindollar Michael W. Fried Preston P. Purdum Donald Jensen Coleman Smith William M. Lee Thomas D. Boyer Amy Lin Simon Pedder Jean DePamphilis | 2001 | Hepatology2001，，2： | 1 |
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