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| 1 | Scintigraphy in laryngopharyngeal and gastroesophageal reflux disease:A definitive diagnostic test?显示文摘AIM: To investigate the utility of scintigraphic studies in predicting response to laparoscopic fundoplication(LF) for chronic laryngopharyngeal reflux symptoms.METHODS: Patients with upper aero-digestive symptoms that remained undiagnosed after a period of 2 mo were studied with conventional p H and manometric studies. Patients mainly complained of cough, sore throat, dysphonia and globus. These patients were imaged after ingestion of 99m-technetium diethylene triamine pentaacetic acid. Studies were quantified with time activity curves over the pharynx, upper and lower oesophagus and background. Late studies of the lungs were obtained for aspiration. Patients underwent LF with post-operative review at 3 mo after surgery.RESULTS: Thirty four patients(20 F, 14 M) with an average age of 57 years and average duration of symptoms of 4.8 years were studied. Twenty four hour p H and manometry studies were abnormal in all patients. On scintigraphy, 27/34 patients demonstrated pharyngeal contamination and a rising or flat pharyngeal curve. Lung aspiration was evident in 50% of patients. There was evidence of pulmonary aspiration in 17 of 34 patients in the delayed study(50%). Pharyngeal contamination was found in 27 patients. All patients with aspiration showed pharyngeal contamination. In the 17 patients with aspiration, graphical time activity curve showed rising activity in the pharynx in 9 patients and a flat curve in 8 patients. In those 17 patients without pulmonary aspiration, 29%(5 patients) had either a rising or flat pharyngeal graph. A rising or flat curve predicted aspiration with a positive predictive value of 77% and a negative predictive valueof 100%. Over 90% of patients reported a satisfactory symptomatic response to LF with an acceptable sideeffect profile. CONCLUSION: Scintigraphic reflux studies offer a good screening tool for pharyngeal contamination and aspiration in patients with gastroesophageal reflux disease. | Gregory L Falk John Beattie Alvin Ing SE Falk Michael Magee Leticia Burton Hans Van der Wall | 2015 | World Journal of Gastroenterology2015，21，12： | 2 |
| 2 | Switching barriers and repurchase intentions in services显示文摘 | Michael A Jones David L Mothersbaugh Sharon E Beatty | 2000 | Journal of Retailing2000，，2： | 2 |
| 3 | 老年高血压患者服用别嘌呤醇后血压的变化显示文摘尿酸可降低青少年血压,表明其在高血压发生发展的病理生理过程中可能起到直接的作用。但是其在老年人高血压中是否扮演同样的角色尚不清楚。该研究通过分析英国临床实践研究数据库的资料,以确定服用别嘌呤醇后血压的改变。方法:纳入〉65岁的使用别嘌呤醇治疗、且有治疗前和治疗时血压读数记录的高血压患者。同时纳入具有可比性的人群作为对照。 | 刘莉 叶鹏 Beattie CJ Fulton RL Higgins P Padmanabhan S McCallum L Walters MR Dominiczak AF Touyz RM Dawson J | 2014 | 中华高血压杂志2014，22，10： | 2 |
| 4 | Posttranscfiptional regulation of ill0 gene expression allows natural killer ceils to express immunoregulatory function 显示文摘 | Maroof A Beattie L Zubairi S | 2008 | Immunity2008，29，2： | 1 |
| 5 | Effect of Polyphosphate and Naphthalene Sulfonate Formaldehyde Condensate on the Rheological Properties of Dewatered Tailings and Cemented Pastebackfill显示文摘 | Huynh L Beattie D A Fornasiero D | 2006 | Minerals Engineering2006，19，1： | 1 |
| 6 | Synthesis of a CrCoAPO-5(AFI) molecular sieve and its activity in cyclohexane oxidation in the liquid phase显示文摘 | Masters A F Beattie James K Roa Adriana L | 2001 | Catal Lett2001，75，34： | 1 |
| 7 | Switching barrier and repurchase intention in service显示文摘 | JONES M A MOTHERSBAUGH D L BEATTY S E | 2000 | Journal of Retailing2000，76，2： | 1 |
| 8 | C-reactive protein and ischemia in users and nonusers of beta-blockers and statins: data from the Heart and Soul Study 显示文摘 | Beattie MS Shlipak MG L iu H | 2003 | Circulation2003，107，38： | 1 |
| 9 | Synchrotron XPS studies of solution exposed chalcopyrite, bornite, and heterogeneous chalcopyrite with bornite显示文摘 | ACRES R G HARMER S L BEATTIE D A | 2010 | International Journal of Mineral Processing2010，94，12： | 1 |
| 10 | Identification of potent and selective amidobipyridyl in-hibitors of protein kinase D显示文摘 | Erik L Meremereredith Kimberly Beattie Bobin Burgis etal | 2010 | J Med Chem2010，，53： | 1 |
| 11 | Synthesis of a CrCo-APO-5(AFI) molecular sieve and its activi- ty in cyelohexane oxidation in the liquid phase显示文摘 | MASTERS A F BEATTIE J K ROA A L | 2001 | Catal Lett2001，75，34： | 1 |
| 12 | Synchrotron XPS, NEXAFS, and ToF-SIMS studies of solution exposed chalcopyrite and heterogeneous chalcopyrite with pyrite显示文摘 | ACRES R G HARMER S L BEATTIE D A | 2010 | Minerals Engineering2010，23，1113： | 1 |
| 13 | Heat trans- fer through tubes with integral spiral fins 显示文摘 | KATZ D L BEATTY K O FOUST A S | 1945 | Trans AMSE1945，70，： | 1 |
| 14 | A comprehensive map of the porcine genome 显示文摘 | Rohrer G A Alexander L J Hu Z Smith T P L Keele JW Beattie C W | 1996 | Genome Res1996，6，： | 1 |
| 15 | Switching barriers and repurchase intentions across service types显示文摘 | Jones M A Mothersbaugh D L Beatty S | 2000 | Journal of Retailing2000，，2： | 1 |
| 16 | Influence of adsorbed polysaccharides and polyacrylamides on talc flotation显示文摘 | Beattie D A Huynh L Kaggwa G B | 2006 | International Journal of Mineral Processing2006，78，4： | 1 |
| 17 | Gait dynamics on an inclined walkway显示文摘 | McIntosh A S Beatty K T Dwan L N | 2006 | Journal of Biomechanics2006，39，13： | 1 |
| 18 | Bacterial degradation of airborne phenol in the phyllosphere 显示文摘 | Sandhu A Halverson L J Beattie G A | 2007 | Environ Microbiol2007，9，2： | 1 |
| 19 | Molten-salt reactor gas pulse impregnation of graphite with carbon显示文摘 | KIPLINGER D V | 1970 | Nucl Applications Techno1970，8，6： | 1 |
| 20 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
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