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| 1 | Endoscopy and polyps-diagnostic and therapeutic advances in management显示文摘Despite multiple efforts aimed at early detection through screening, colon cancer remains the third leading cause of cancer-related deaths in the United States, with an estimated 51000 deaths during 2013 alone. The goal remains to identify and remove benign neoplastic polyps prior to becoming invasive cancers. Polypoid lesions of the colon vary widely from hyperplastic, hamartomatous and inflammatory to neoplastic adenomatous growths. Although these lesions are all benign, they are common, with up to one-quarter of patients over 60 years old will develop pre-malignant adenomatous polyps. Colonoscopy is the most effective screening tool to detect polyps and colon cancer, although several studies have demonstrated missed polyp rates from 6%-29%, largely due to variations in polyp size. This number can be as high as 40%, even with advanced (> 1 cm) adenomas. Other factors including sub-optimal bowel preparation, experience of the endoscopist, and patient anatomical variations all affect the detection rate. Additional challenges in decision-making exist when dealing with more advanced, and typically larger, polyps that have traditionally required formal resection. In this brief review, we will explore the recent advances in polyp detection and therapeutic options. | Scott R Steele Eric K Johnson Bradley Champagne Brad Davis Sang Lee David Rivadeneira Howard Ross Dana A Hayden Justin A Maykel | 2013 | World Journal of Gastroenterology2013，19，27： | 16 |
| 2 | Phytochemical and anti-bacterial activity of epidermal glands extract of Christella parasitica (L.) H. Lev.显示文摘Objective:To study the morphology,biochemistry and bioactivity of the epidermal glands of the glandular morphotype of Christella parasitica(C.parasitica)(L.) H.Lev.Methods: Morphological studies on epidermal glands were earned out by using light microscope and scanning electron microscope.To prepare the extract,the shade-dried fronds of glandular morphotype were soaked in acetone.For antibacterial studies paper disc method was followed by using various pathogenic bacteria.Results:Detailed micromorphological,phytochemical and bioactivity studies on a medicinal fern C.parasitica(L.) H.Lev.showed its inlraspecific variation in antibacterial activity.The presence or absence of the epidermal glands was the key factor for antibacterial activity in the morphovariants of this species.The epidermal glands were orange-coloured,stalked and elongated ones of about 84.2μm×45μm,and distributed on the undersurface of cosla,coslules and veins in croziers,young and mature leaves.Frequency of glands varied from 15/cm on costa in mature leaves to 140/cm on costules in croziers.The acetone extract of the glands showed antibacterial activities and also toxic effect against mosquito larvae and tadpoles of frog.Preliminary phytochemical analysis and HPLC studies of the gland extract showed the presence of various kinds of terpenoids,alkaloids,tannins,saponins and flavonoids in it.Conclusions:The present study shows that epidermal glands of the glandular morphotype of C. parasitica(L.) H.Lev.have several bioactive compounds and such rare moiphovariant should be conserved in nature.The next step is to isolate the pure compounds and to screen the bioactivity of individual compounds of the epidermal glands. | Paul Raj K Irudayaraj V Johnson M Patric Raja D | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 14 |
| 3 | Operative considerations for rectovaginal fistulas显示文摘To describe the etiology, anatomy and pathophysiology of rectovaginal fistulas(RVFs); and to describe a systematic surgical approach to help achieve optimal outcomes. A current review of the literature was performed to identify the most up-to-date techniques and outcomes for repair of RVFs. RVFs present a difficult problem that is frustrating for patients and surgeons alike. Multiple trips to the operating room are generally needed to resolve the fistula, and the recurrence rate approaches40% when considering all of the surgical options. At present, surgical options range from collagen plugs and endorectal advancement flaps to sphincter repairs or resection with colo-anal reconstruction. There are general principles that will allow the best chance for resolution of the fistula with the least morbidity to the patient. These principles include: resolving the sepsis, identifying the anatomy, starting with least invasive surgical options, and interposing healthy tissue for complex or recurrent fistulas. | Kevin R Kniery Eric K Johnson Scott R Steele | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 7 |
| 4 | New Pd(Ⅱ)- and Ni(Ⅱ)-Based Catalysts for Polymerization of Ethylene and α-Olefins显示文摘 | Johnson L K Killian C M Brookhart M | | 0，，： | 6 |
| 5 | Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth显示文摘AIM: To investigate the functional significance of insulin-like growth factor binding protein-5 (IGFBP-5) overexpression in pancreatic cancer (PaC).METHODS: The effects of IGFBP-5 on cell growth were assessed by stable transfection of BxPC-3 and PANC-1 cell lines and measuring cell number and DNA synthesis. Alterations in the cell cycle were assessed by flow cytometry and immunoblot analyses. Changes in cell survival and signal transduction were evaluated after mitogen activated protein kinase and phosphatidylinositol 3-kinase (PI3K) inhibitor treatment.RESULTS: After serum deprivation, IGFBP-5 expression increased both cell number and DNA synthesis in BxPC-3 cells, but reduced cell number in PANC-1 cells. Consistent with this observation, cell cycle analysis of IGFBP-5-expressing cells revealed accelerated cell cycle progression in BxPC-3 and G2/M arrest of PANC-1 cells. Signal transduction analysis revealed that Akt activation was increased in BxPC-3, but reduced in PANC-1 cells that express IGFBP-5. Inhibition of PI3K with LY294002 suppressed extracellular signal-regulated kinase-1 and -2 (ERK1/2) activation in BxPC-3, but enhanced ERK1/2 activation in PANC-1 cells that express IGFBP-5. When MEK1/2 was blocked, Akt activation remained elevated in IGFBP-5 expressing PaC cells; however, inhibition of PI3K or MEK1/2 abrogated IGFBP-5-mediated cell survival.CONCLUSION: These results indicate that IGFBP-5 expression affects the cell cycle and survival signal pathways and thus it may be an important mediator of PaC cell growth. | Sarah K Johnson Randy S Haun | 2009 | World Journal of Gastroenterology2009，15，27： | 5 |
| 6 | Re- sponses in ovulation rate, embryonal survival, and litter traits in swine to 14 generations of selection to increase litter size 显示文摘 | JOHNSON R K NIELSEN M K CASEY D S | 1999 | J Anim Sci1999，77，3： | 5 |
| 7 | Copolymerization of Ethylene and Propyiene with Functionalized Vinyl Monomers by PalladiumII) Catalysts显示文摘 | Johnson L K Killian C M Arthur S D | | 0，，： | 4 |
| 8 | Prevalence of unsuspected thyroid nodules in adults on contrast enhanced 16-and 64-MDCT of the chest显示文摘AIM: To determine the prevalence of unsuspected thyroid nodules on contrast enhanced 16and 64-modified discrete cosine transform (MDCT) of the chest, in a population of adult outpatients imaged for indications other than thyroid disease. METHODS: This retrospective study involved review of intravascular contrast-enhanced MDCT scans of the chest from 3077 consecutive adult outpatients, to identify unsuspected thyroid nodules. Exclusion criteria included history of thyroid cancer, known thyroid nodules or thyroid disease and risk factors for thyroid cancer, as evidenced by their medical records. One of 9 radiologists recorded number of nodules, location and bidirectional measurement of largest nodule, as well as amount of thyroid visualized on the chest computed tomography (CT). Presence of nodule was correlated with age, gender, race and percentage of thyroid imaged. RESULTS: A total of 2510 (2510/3077 or 81.6%) study subjects were included in the data analysis; among them,one or more nodules were identified in 629 subjects (629/2510 or 25.1%), with 242 (242/629 or 38.5%) having multiple nodules. Patients with nodule(s) were significantly older than those without (64 ± 13 years vs 58 ± 14 years, P < 0.0001), and female gender was associated with presence of nodule(s) (373/1222 or 30.5% vs 256/1288 or 19.9%, P < 0.0001). Women were also more likely having multiple nodules (167/373 or 44.8%) compared to men (75/256 or 29.3%, P < 0.0001). The majority of nodules (427/629 or 67.9%) were less than 1 cm. CONCLUSION: This retrospective review revealed a prevalence of 25.1% for unsuspected thyroid nodules on contrast-enhanced chest CT. | Sameer Ahmed Pamela T Johnson Karen M Horton Atif Zaheer Saline Tsai Elliot K Fishman | 2012 | World Journal of Radiology2012，4，7： | 4 |
| 9 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 10 | Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study显示文摘 | JT Moller P Cluitmans LS Rasmussen P Houx H Rasmussen J Canet P Rabbitt J Jolles K Larsen CD Hanning O Langeron T Johnson PM Lauven PA Kristensen A Biedler H van Beem O Fraidakis JH Silverstein JEW Beneken JS Gravenstein | 1998 | The Lancet . 1998 (9106)1998，，9106： | 2 |
| 11 | Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)显示文摘 | Claudia Allemani Hannah K Weir Helena Carreira Rhea Harewood Devon Spika Xiao-Si Wang Finian Bannon Jane V Ahn Christopher J Johnson Audrey Bonaventure Rafael Marcos-Gragera Charles Stiller Gulnar Azevedo e Silva Wan-Qing Chen Olufemi J Ogunbiyi Bernard R | 2015 | The Lancet . 2015 (9972)2015，，： | 2 |
| 12 | MicroRNA-181b通过调节金属蛋白酶组织抑制因子3和弹性蛋白影响动脉粥样硬化和动脉瘤显示文摘动脉粥样硬化和动脉瘤是全世界人口的主要致死原因。微小RNA(microRNAs,miR)是基因和蛋白表达的关键决定因素,miR异常表达与许多心血管病有关。目前对它们在动脉粥样硬化斑块和腹主动脉瘤(abdominal aortic aneurysm,AAA)稳定性中的作用了解甚少。 | 刘莉 叶鹏 Di Gregoli K Mohamad Anuar NN Bianco R White SJ Newby AC George SJ Johnson JL | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 13 | Stretch flanging of V shaped sheet metal blanks显示文摘 | Wang N M Johnson L K Tang S C | 1983 | J Applied Metalworking1983，3，3： | 2 |
| 14 | Multidisciplinary approach for multifocal, bilobar hepatocellular carcinoma: A case report and literature review显示文摘BACKGROUND Hepatocellular carcinoma(HCC) is the second most lethal malignancy worldwide. There has been virtually no change in the survivability of HCC in spite of improvement in therapies. Surgery is considered the ideal first, curative intervention, however most patients present in advanced stages with unresectable disease. Therefore, systemic and liver-directed non-operative therapies are initially offered to downstage the disease. To ensure optimal management, a multidisciplinary team approach is often warranted. Our case highlights the benefits of a multidisciplinary approach in a young woman with multifocal, bilobar HCC.CASE SUMMARY A 36-year-old Chinese woman with untreated hepatitis B was found to have large bilobar HCC during work up for abdominal pain. Her initial serum alphafetoprotein was significantly elevated to 311136 ng/mL. Computed tomography scan demonstrated bulky bilobar liver masses, consistent with intermediate stage HCC, Barcelona Clinic Liver Cancer Stage B. Her case was discussed and a personalized care plan was developed at the Multidisciplinary Center for Advanced Minimally Invasive Liver Oncologic Therapies at the University of Washington. She initially underwent bilobar transarterial chemoembolization with partial response of the left lobar tumor. Salvage hypofractionated proton beam radiation therapy was delivered to the right lobe followed by two additional transarterial chemoembolizations to the left lobe with good response.Finally, to remove left lobar residual disease, she was taken to the operating roomfor a left hepatectomy eleven months after her initial presentation. She continues to be without evidence of disease.CONCLUSION Coordinating the multiple HCC treatment modalities is complex and our case highlights the benefits of a multidisciplinary approach. | Kevin P Labadie Stephanie K Schaub Derek Khorsand Guy Johnson Smith Apisarnthanarax James O Park | 2019 | World Journal of Hepatology2019，11，1： | 2 |
| 15 | Fix and replace:An emerging paradigm for treating acetabular fractures in older patients显示文摘Acetabular fractures in older patients are challenging to manage.The 'fix and replace' construct may present a new paradigm for the management of these injuries.We present the current challenge of acetabular fractures in older patients.We present this in the context of the current literature.This invited editorial presents early results from our centre and the ongoing challenges are discussed. | Elizabeth K Tissingh Abigail Johnson Joseph M Queally Andrew D Carrothers | 2017 | World Journal of Orthopedics2017，8，3： | 2 |
| 16 | 尿酸是正常高值血压发展为高血压的一个重要危险标志物显示文摘正常高值血压常发展为高血压,是一个与心血管病和脑卒中高死亡率和高发病率相关的事件。然而,正常高值血压发展成高血压的危险因素仍不清楚。研究者采用年龄(52.1±11.0)岁日本成年高血压患者3584例(2081例为男性)的资料进行前瞻性群体研究,研究对象在2004年被发现处于正常高值血压阶段,并在2009年重新进行检查。 | 黄洁 叶鹏 Kuwabara M Hisatome I Niwa K Hara S Roncal-Jimenez CA Bjornstad P Nakagawa T Andres-Hernando A Sato Y Jensen T Garcia G Rodriguez-Iturbe B Ohno M Lanaspa MA Johnson RJ | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 17 | 紫杉醇局部治疗抑制猪静脉桥新生内膜形成和增厚的实验研究显示文摘目的 :局部药物治疗是一个很好的防治静脉桥病变的策略。本研究用抗细胞增殖药物紫杉醇处理大隐静脉桥后植入猪的颈动脉 ,以观察紫杉醇的抗细胞增殖作用在抑制静脉桥内膜平滑肌细胞增殖、迁移导致内膜形成和增厚的效果。方法 :将 10头猪的 2 0只大隐静脉桥分为两组。治疗组 :将大隐静脉桥 10只置于含有 10 μmol/L浓度的紫杉醇溶液中 (先用该溶液灌洗 )浸泡 1h后植入猪的颈动脉 ,紫杉醇是溶解在 2 5 μl/L的无水酒精中 ,对照组 10只大隐静脉桥置于单纯的酒精中浸泡。 4周后取开放的静脉桥进行组织学分析。结果 :①治疗组静脉桥新生内膜面积 (1 5 9± 0 95 )mm2 ,对照组新生内膜面积高达 (2 43± 1 3 5 )mm2 ,治疗组显著低于对照组 ,两组比较有非常显著的差异 ,P <0 0 1;②治疗组内膜平滑肌细胞密度均值为 (3 681± 193 5 ) /mm2 ,对照组为 (4 60 7± 1993 ) /mm2 ,两组比较有显著性差异 ,P <0 0 5 ;中膜平滑肌细胞密度均值治疗组 (2 13 9± 73 4) /mm2 ,对照组(3 62 9± 3 2 0 7) /mm2 ,两组比较有显著性的差异 ,P <0 0 5。结论 :紫杉醇可显著抑制静脉桥内膜、中膜平滑肌细胞的增殖 ,抑制新生内膜的形成 ,证明紫杉醇可在防治静脉桥闭塞方面发挥独特作用。 | 吴隐雄 Martin H Chamberlain Thomas Johnson Jason L Johnson Andrew C Newby Gianni D Angelin Martin Oberhoff Karl K Karsch | 2003 | 中国循环杂志2003，18，6： | 2 |
| 18 | 管柱腐蚀的分析和处理方法优选显示文摘列举了作业工处理油管腐蚀的几种方法 。 | G.R.'Bob'Moe Carl K Johnson 马文英 | 2002 | 石油石化节能2002，0，11： | 2 |
| 19 | Lactic acid production in a mixed- culture biofilm reactor显示文摘 | DEMIRCI A POMETTO A Johnson K | 1993 | Appl Environ Microbiol1993，59，： | 1 |
| 20 | Identifiaction and validation of the mitochondrial F1 Fo-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423 显示文摘 | JOHNSON K M CHEN X BOITANO A | 2005 | Chem Boil2005，12，4： | 1 |
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