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| 1 | Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis显示文摘Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics.We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained database.Multiple logistic regression was used to identify predictors of ERCP-confirmed choledocholithiasis.MLMs were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to MLMs.Results:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed chol-edocholithiasis.Logistic regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed choledocholithiasis.Among the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,respectively.ASGE high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD diameter,and choledocholithiasis on pre-ERCP noninvasive imaging predict ERCP-confirmed choledocholithiasis with good sensitivity and specificity and outperform the ASGE criteria for patients with suspected choledocholithiasis. | Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian | 2021 | Liver Research2021，5，4： | 3 |
| 2 | A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse显示文摘 | ADVANI A S SHADMAN M ALI-OSMAN F BARKER A RYBICKI L KALAYCIO M SEKERES M A de CASTRO C M DIEHL L F MOORE J O BEAVEN A COPELAN E SOBECKS R TALEA P RIZZIERI D A | 2010 | Clinical lymphoma Myeloma & Leukemia2010，10，6： | 1 |
| 3 | Phosphorylation of the liverX receptors显示文摘 | Chen M Bradley MN Beaven SW | 2006 | FEBSLett2006，580，20： | 1 |
| 4 | Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha显示文摘 | Chen M Beaven S Tontonoz P | 2005 | Lipid Res2005，46，12： | 1 |
| 5 | The A3 adeno-sine receptors is the unique adenosine receptor which facilitates release of allergic mediators in mast cells显示文摘 | Ramkumar V Stiles G L Beaven M A | 1993 | J Biol Chem1993，268，16： | 1 |
| 6 | Identication and characterization of two alternatively spliced transcript variants of human liver X receptor á显示文摘 | Chen M Beaven S Tontonoz P | 2005 | Lipid Res2005，46，： | 1 |
| 7 | Compound 48/80activates mast cell phospolopase D via heterotrimeric GTP-bindingproteins显示文摘 | Chahdi A Fraundorfer P F Beaven M A | 2000 | J Pharmacol Exp Ther2000，292，1： | 1 |
| 8 | Microstructure and mechanical properties of Cu-bearing MMA C-Mn weld metal显示文摘 | Es-Souni M Beaven P A Evans G M | 1991 | WRA1991，，23： | 1 |
| 9 | Identification and characterization of two alternatively spliced transcript variants of human liver X receptor α显示文摘 | Chen M Beaven S Tontonoz P | 2005 | J Lipid Res2005，46，12： | 1 |
| 10 | Regulation of mast cell responses in health and disease显示文摘 | Gilfillan AM Beaven M A | 2011 | Crit Rev Im?munol2011，31，6： | 1 |
| 11 | Three weeks of oe clusion training can improve strength and power in trained ath- letes显示文摘 | COOK C J KILDUFF L P BEAVEN C M | 2013 | Int J Sports Physiol Perform2013，8，4： | 1 |
| 12 | The MARS for squat, countermovement, and standing long jump performance analyses: are measures reproducible? 显示文摘 | Hebert-Losier K Beaven C M | 2014 | J Strength Cond Res2014，28，7： | 1 |
| 13 | Phosphorylation of the liver X receptors 显示文摘 | Chen M Bradley MN Beaven SW | 2006 | FEBS Lett2006，580，20： | 1 |
| 14 | Activation of exocytosis by the heterotrimeric G protein Gi3 显示文摘 | Aridor M Rajmilevich G Beaven MA | 1993 | Science1993，262，： | 1 |
| 15 | Synergistic activation of phosphotipases Cγ and Cβ:a novel mechanism of PI3K in depedent enhancement of FcεRI-induced mast cell media tor release显示文摘 | Kuehn H Beaven M Ma H el al | 2008 | Cell Signal2008，20，4： | 1 |
| 16 | Certain inhibitors of protein serine/threonine kinases also inhibit tyrosine phosphorylation of phospholipase C gamma 1 and other proteins and reveal distinct roles for tyrosine kinase (s) and protein kinase C in stimulated, rat basophilic RBL- 2H3 cells显示文摘 | Yamada K Jelsema G L Beaven M A | 1992 | J Immunol1992，149，3： | 1 |
| 17 | Regulation of mast cell re- sponses in health and disease 显示文摘 | GILFILLAN A M BEAVEN M A | 2011 | Crit Rev Immunol2011，31，6： | 1 |
| 18 | Weighting function selection in the H~ design process 显示文摘 | BEAVEN R W WRIGHT M T SEAWARD D R | 1996 | Control Engi- neering Practice1996，4，5： | 1 |
| 19 | Weighting function selection in the H∞ design process显示文摘 | BEAVEN R W WRIGHT M T SEAWARD D R | 1996 | Control Engineering Practice1996，4，5： | 1 |
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