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| 1 | Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy?显示文摘Mesenchymal stromal cells(MSCs) are currently being investigated for use in a wide variety of clinical applications. For most of these applications, systemic delivery of the cells is preferred. However, this requires the homing and migration of MSCs to a target tissue. Although MSC hominghas been described, this process does not appear to be highly efficacious because only a few cells reach the target tissue and remain there after systemic administration. This has been ascribed to low expression levels of homing molecules, the loss of expression of such molecules during expansion, and the heterogeneity of MSCs in cultures and MSC culture protocols. To overcome these limitations, different methods to improve the homing capacity of MSCs have been examined. Here, we review the current understanding of MSC homing, with a particular focus on homing to bone marrow. In addition, we summarize the strategies that have been developed to improve this process. A better understanding of MSC biology, MSC migration and homing mechanisms will allow us to prepare MSCs with optimal homing capacities. The efficacy of therapeutic applications is dependent on efficient delivery of the cells and can, therefore, only benefit from better insights into the homing mechanisms. | Ann De Becker Ivan Van Riet | 2016 | World Journal of Stem Cells2016，8，3： | 37 |
| 2 | Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer显示文摘AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing. | Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 3 | 采用意大利多中心前瞻性研究以评估16层及64层MDCT对计划行冠状动脉造影病人的阴性预测值(NIMISCAD-意大利冠心病无创性多中心性研究)显示文摘这是一项多中心的前瞻性研究.通过应用不同制造商生产的MDCT设备,对计划行选择性冠状动脉造影(CA)的病人行MDCT检查以对其诊断冠心病(CAD)的价值进行评估。2004年7月-2006年6月间.在20所国家医院前瞻性地征集了367例病人。对于每种类型的MDCT(≥16层),CT检查均采用标准化/优化的扫描方案,并且与2周内进行的定量冠状动脉造影比较。共有284例病人(81%)应用16层MDCT进行检查,66例病人(19%)应用64层MDCT进行检查。初步分析采用院内/院外的方法,评估对1例病人的阴性预测值(NPV)。 | R. Marano F. De Cobelli I. Floriani C. Becker C. Herzog M. Centonze 王卿(译) 李威(校) | 2009 | 国际医学放射学杂志2009，32，4： | 3 |
| 4 | LincRNA-p21 Suppresses Target mRNA Translation显示文摘 | Je-Hyun Yoon Kotb Abdelmohsen Subramanya Srikantan Xiaoling Yang Jennifer L. Martindale Supriyo De Maite Huarte Ming Zhan Kevin G. Becker Myriam Gorospe | 2012 | Molecular Cell2012，，4： | 2 |
| 5 | Mapping summer soybean and corn with remote sensing on Google Earth Engine cloud computing in Parana state – Brazil显示文摘Brazilian farming influences directly the worldwide economy.Thus,fast and reliable information on areas sown with the main crops is essential for planning logistics and public or private commodity market policies.Recent farming practices have embraced remote sensing to provide fast and reliable information on commodity dynamics.Medium-to-low resolution free orbital images,such as those from Landsat 8 and Sentinel 2,have been used for crop mapping;however,satellite image processing requires high computing power,especially when monitoring vast areas.Therefore,cloud data processing has been the only feasible option to deal with a large amount of orbital data and its processing and analysis.Thus,our goal was to develop a method to map the two main crops(soybeans and corn)in Paraná,one of the major Brazilian state producers.Landsat-8,Sentinel-2,SRTM+,and field data from 2016 to 2018 were used with the Simple Non-Iterative Clustering segmentation method and the Continuous Naive Bayes classifier,to identify cropped areas.A minimum global accuracy of 90%was found for both crops.Comparison with field data showed correlations of 0.96 and agreement coefficients no lower than 0.86.This ensures mapping quality when using Sentinel and/or Landsat imagery on the GEE platform. | Alex Paludo Willyan Ronaldo Becker Jonathan Richetti Laíza Cavalcante De Albuquerque Silva Jerry Adriani Johann | 2020 | International Journal of Digital Earth2020，13，12： | 2 |
| 6 | Fatigue in children and adolescents with inflammatory bowel disease显示文摘AIM To identify factors other than active disease and anemia that contribute to fatigue in pediatric inflammatory bowel disease(IBD).METHODS We performed an electronic search in Medline and EMBASE from their inception to May 2017 using the search term 'fatigue' or the related keywords 'physical impairment' and 'inflammatory bowel disease' with the filter 'child'(age 0-18 years). Cross-sectional and case-control studies were included. We restricted our search to studies published in English. We used the PRISMA checklist and flow diagram. Duplicate articles were manually deleted in End Note. To identify further relevant studies, we checked the reference lists of the selected articles.RESULTS We identified 149 papers, of which 19 were retrieved for full text review. Eleven studies were subsequently excluded because fatigue was not evaluated as an outcome measure. Eight papers focused on the desired topic and were discussed in the final analysis. A lack of uniformity of outcome measures made the pooling of data impossible. In all but one study, questionnaires were used to evaluate fatigue. In the remaining study, an accelerometer was used to measure daily activities, sleeping time and their relationships with fatigue in a more quantifiable manner. Adolescents with IBD are significantly more fatigued than healthy controls. In addition to active disease, increased anxiety or depression and disturbed family relationships were frequently reported predictors of fatigue. Quantitative measurement of physical activity in patients with Crohn's disease showed a reduction in the number of steps per day, and patients with ulcerative colitis had a shorter duration of physical activity during the day.CONCLUSION Fatigue in pediatric IBD is related to a combination of biological, functional and behavioral factors, which should all be taken into account when managing fatigue. | Els Van de Vijver Ann Van Gils Laura Beckers Yannick Van Driessche Nicolette Dorien Moes Patrick Ferry van Rheenen | 2019 | World Journal of Gastroenterology2019，25，5： | 2 |
| 7 | Oocytes in the empty follicle: a controversial syndrome显示文摘 | Mustafa Aktas Nicole G. Beckers Wouter G. van Inzen Arie Verhoeff Diederick de Jong | 2005 | Fertility and Sterility2005，，： | 2 |
| 8 | Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation显示文摘 | Onno J de Boer Floris Hirsch Allard C van der Wal Chris M van der Loos Pranab K Das Anton E Becker | 1997 | Atherosclerosis1997，，2： | 1 |
| 9 | Atherosclerosis,inflammation,and infection显示文摘 | de Boer OJ van der Wal AC Becker AE | 2000 | Pathol2000，190，3： | 1 |
| 10 | Development of a risk tool for deliberate self-extubation in intensive care patients显示文摘 | Moons P Sels K De Becker W | 2004 | Intensive Care Med2004，30，7： | 1 |
| 11 | Bone marrow-derived mes- enchymal stromal cells are attracted by multiple myeloma cell- produced chemokine CCL25 and favor myeloma cell growth in vitro and in vivo显示文摘 | Xu S Menu E De Becker A | 2012 | Stem Cells2012，30，2： | 1 |
| 12 | Development of a risk assessment tool for deliberate self-extubation in intensive care patients显示文摘 | Moons P Sels K De Becker W | | 0，，07： | 1 |
| 13 | Conflicts and communal forest management in northern Bolivia 显示文摘 | Will de Jong Sergio Ruiz Michel Becker | 2006 | Forest Policy and Economics2006，，8： | 1 |
| 14 | Nausea,vomiting,and hiccups:a review of mec-hanisms and treatment 显示文摘 | Becker DE | 2010 | Anesth Pmg2010，57，4： | 1 |
| 15 | Risk fac- tors for recurrent sinus surgery in cystic fibrosis: review of a decade of experience显示文摘 | Becker S S de Alarcon A Bomeli S R | 2007 | Am J Rhinol2007，21，4： | 1 |
| 16 | Study on the flow structure in an aerated flat apparatus using laser Doppler anemometry显示文摘 | Becker S De Bie H Sweeney J | 2000 | Chemical Engineering and Technology2000，23，3： | 1 |
| 17 | The differential regulation of human telomerase reverse transcriptase and vascular endothelial growth factor may contribute to the clinically more aggressive behavior of p693-positive breast carcinomas 显示文摘 | Ribeiro-Silva A Becker de Moura H Ribeiro do Vale F | 2005 | Int J Biol Markers2005，20，4： | 1 |
| 18 | Mi- crofluidic cell separation by 2-dimensional dielectro- phoresis 显示文摘 | de Gasperis G Yang Jun Becker F F | 1999 | Biomedical Microdevices1999，2，1： | 1 |
| 19 | Computer-aided planning in orthognathic surgery-systematic review 显示文摘 | Haas Jr OL Becker OE de Oliveira RB | 2014 | Int J Oral Maxillofac Surg2014，44，3： | 1 |
| 20 | Bone marrow-derived mesenchymal stromal cells are attracted by multiple myeloma cell-produced chemokine CCL25and favor myeloma cell growth in vitro and in vivo显示文摘 | Xu S Menu E De Becker A | 2012 | Stem Cells2012，30，2： | 1 |
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