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| 1 | Different profile of cytokine synthesis according to the severity of acute pancreatitis显示文摘AIM: To evaluate the cellular synthetic ability of cytokines involved in pro- and anti-inflammatory reactions in patients with AP.METHODS: Sixty-seven patients with AP (16 severe,51 mild) and 10 controls were included in the study.Cultures of whole blood were performed in samples obtained within the first 72 h from the onset of pain.Serum levels of interleukins (IL) 6, 8, 10, and TNF-α were measured at baseline and in the supernatant of cultures with (functional reserve) or without stimulation with phytohemaglutinin.RESULTS: Basal levels of cytokines were significantly higher in patients with severe AP. A significant increase of all pro-inflammatory cytokines vs basal levels was observed in the supernatant after 24 h of whole blood cultures in patients, but not in controls. In contrast, IL-10 increased significantly in the supernatant of cultures only in patients with mild AP. Cells showed a statistically significant functional reserve for all IL in patients with mild, but only for pro-inflammatory cytokines in patients with severe AP.CONCLUSION: A marked activation of immune system may be observed in patients with AP, being balanced between pro- and anti-inflammatory cytokines in patients with mild but not severe AP. A reduced functional reserve for the synthesis of IL-10 may be observed in patients with severe AP, which might lead to a worst prognosis. | Raquel Laveda Juan Martínez Carlos Mu■oz Juan Carlos Penalva Jesus Sáez Germán Belda Salvador Navarro Faust Feu Anton Mas José Ma Palazón José Sánchez-Payá José Such Miguel Pérez-Mateo | 2005 | World Journal of Gastroenterology2005，11，34： | 24 |
| 2 | Real-Time PCR for Diagnosing Helicobacter pylori Infection in Patients with Upper Gastrointestinal Bleeding: Comparison with Other Classical Diagnostic Methods显示文摘 | Jesús Saez Sofía Belda Miguel Santibá?ez Juan Carlos Rodríguez Javier Sola-Vera Antonio Galiana Montserrat Ruiz-García Alicia Brotons Elena López-Girona Eva Girona Carlos Sillero Gloria Royo | 2012 | Journal of Clinical Microbiology2012，，10： | 2 |
| 3 | Screening for retinopathy of prematurity: is it painful? 显示文摘 | Belda S Pallds CR De la Cruz J | 2004 | Biol Neonate2004，86，3： | 1 |
| 4 | Salinity effects on the xylem vessels in tomato fruit among cultivars with different susceptibilities to blossom-end rot显示文摘 | Belda R M Fenlen J S Ho L C | 1996 | J of Horticultural Science1996，71，2： | 1 |
| 5 | Recoverable resin-supported pyridylamide ligand for microwave-accelerated molybdenum-catalyzed asymmetric allylic alkylations:enantioselective synthesis of baclofen 显示文摘 | Belda O Lundgren S Moberg C | 2003 | Org Lett2003，5，： | 1 |
| 6 | Real-Time PCR for Diagnosing Helicobacter pylori Infection in Patients with Upper Gastrointestinal Bleeding: Comparison with Other Classical Diagnostic Methods显示文摘 | Jesús Saez Sofía Belda Miguel Santibá?ez Juan Carlos Rodríguez Javier Sola-Vera Antonio Galiana Montserrat Ruiz-García Alicia Brotons Elena López-Girona Eva Girona Carlos Sillero Gloria Royo | 2012 | Journal of Clinical Microbiology2012，，10： | 1 |
| 7 | Screening for retinopathy of prematurity, is it painful?显示文摘 | Belda S Pallas CR De la Cruz J | 2004 | Bioi Neonate2004，86，3： | 1 |
| 8 | Recoverable resin-supported pyridylamide ligand for microwave-accelerated molybdenum-catalyzed asymmetric allylic alkylations:enantioselective synthesis of Baclofen 显示文摘 | BELDA O LUNDGREN S MOBERG C | 2003 | Org Lett2003，5，13： | 1 |
| 9 | A single exposure to immobilization causes long-lasting pituitary-adre,al and behavioral sensitization to mild stressurs 显示文摘 | Belda X Fuentes S Nadal R | 2008 | Horm Behav2008，54，5： | 1 |
| 10 | Low E-cadherin expression in bladder cancer at the trascriptional and protein level provides prognostic information显示文摘 | Popov Z Gil Diez de Medina S Lefrere Belda MA | 2000 | Br J Cancer2000，83，2： | 1 |
| 11 | Exposure to severe stressors causes long-lasting dysregulation of resting and stress-induced activation of the hypothalamic-pituitary-adrenal axis 显示文摘 | Belda X Rotllant D Fuentes S | 2008 | Ann N Y Acad Sci2008，1148，： | 1 |
| 12 | Recoverable resin-supported pyridylamide ligand for microwave-accelerated molybdenum-catalyzed asymmetric allylic alkylations: enantioselective synthesis of baclofen 显示文摘 | Belda O Lundgren S Moberg C | 2003 | Org Lett2003，5，13： | 1 |
| 13 | Markers of Airway Remodeling in Induced Sputum From Healthy Smokers显示文摘 | Avilés B Belda J Margarit G | 2006 | Arch Bronconeumol2006，42，： | 1 |
| 14 | Screening for retinopathy of prematurity:Is it painfui显示文摘 | Pallas CR de la Cruz J | 2004 | Biol Neonate2004，86，3： | 1 |
| 15 | Screening for retinopathy of prematurity~ is it painful?显示文摘 | Belda S Pallds CR De la Cruz J | 2004 | Biol Neonate2004，86，3： | 1 |
| 16 | Sentinel lymph node biopsy in cervix and corpus uteri cancers 显示文摘 | Lelievre L Camatte S LeFrere -belda MA | 2004 | Int J Gynecol Cancer2004，14，2： | 1 |
| 17 | Quantification of Helico- batter pylori in gastric mucosa by real-time polymerase chain reac- tion: comparison with traditonal diagnostic methods 显示文摘 | Belda S Saez J SantibOfiez M | 2012 | Diagn Mierobiol Infect Dis2012，74，3： | 1 |
| 18 | Relationship between tobacco, cagA and vacA il virulence factors and bacterial load in patients infected by Helicobacter pylori显示文摘 | Santib6~ez M Aguirre E Belda S | 2015 | PLoS One2015，10，12： | 1 |
| 19 | Profiles of the 2 INK4a gene products, p16 and p14ARF, in human reference urothelium and bladder carcinomas, according to pRb and p53 protein status显示文摘 | Le Frere Belda MA Gil Diez de Medina S Daher A | 2004 | Hum Pathol2004，35，7： | 1 |
| 20 | Sentinellymph node biopsy in cervix and corpus uteri cancers 显示文摘 | Lelievre L Camatte S Le Frere - Belda MA | 2004 | Int J Gynecol Cancer2004，14，2： | 1 |
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