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| 1 | Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome显示文摘AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome(ARDS).METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of i NO(20 ppm) or nebulized epoprostenol(10 μg/mL) was done in all patients. Thereafter, inhaled milrinone(1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide(iN O) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen(PaO_2) were recorded before and after each inhaled therapyadministration.RESULTS The majority of ARDS were of pulmonary cause(n = 13) and pneumonia(n = 7) was the leading underlying initial disease. Other pulmonary causes of ARDS were: Post cardiopulmonary bypass(n = 2), smoke inhalation injury(n = 1), thoracic trauma and pulmonary contusions(n = 2) and aspiration(n = 1). Two patients had an extra pulmonary cause of ARDS: A polytrauma patient and an intra-abdominal abscess Inhaled nitric oxide, epoprostenol, inhaled milrinone and the combination of inhaled milrinone and i NO had no impact on systemic hemodynamics. No significant adverse events related to study medications were observed. The median increase of PaO 2 from baseline was 8.8 mmH g [interquartile range(IQR) = 16.3], 6.0 mm Hg(IQR = 18.4), 6 mm Hg(IQR = 15.8) and 9.2 mm Hg(IQR = 20.2) respectively with i NO, epoprostenol, inhaled milrinone, and i NO added to milrinone. Only i NO and the combination of inhaled milrinone and i NO had a statistically significant effect on PaO 2. CONCLUSION When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milrinone appeared safe but failed to improve oxygenation in ARDS. | Martin Albert Daniel Corsilli David R Williamson Marc Brosseau Patrick Bellemare Stéphane Delisle Anne QN Nguyen France Varin | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 2 | Room tem- perature muhifrequency erbium-doped fiber lasers an- chored on the ITU frequency grid 显示文摘 | Bellemare A Kar6sek M Rochette M | 2000 | Journal of Light- wave Technology2000，18，6： | 1 |
| 3 | A Broadly Tunable Erbium-Doped Fiber Ring Laser:Experimentation and Modeling显示文摘 | Bellemare A Karasek M Riviere C | 2001 | IEEE J Select Topics Quantum Electron2001，7，： | 1 |
| 4 | Synthetic Plasmodiurn-like hemozoin activates the immune response: a morphologyfunction study 显示文摘 | Jaramillo M Bellemare MJ Martel C | 2009 | PLoS One2009，4，9： | 1 |
| 5 | Effect of pressure and timing of contraction on human diaphragm fatigue 显示文摘 | Bellemare F Grassino A | 1982 | J Appl Physiol1982，53，5： | 1 |
| 6 | The impact of germline genetic variations in hydroxysteroid (17-beta) dehydrogenases on prostate cancer outcomes after prostatectomy显示文摘 | Audet-Walsh E Bellemare J Lacombe L | | 0，，： | 1 |
| 7 | Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes显示文摘 | ELPEK K G RUBINSTEIN M P BELLEMARE PELLETIER A | 2010 | Proc Natl Acad Sci U S A2010，107，21： | 1 |
| 8 | Reconsidering Conventional Explanations of the Inverse Productivity - SizeRelationship显示文摘 | Barrett C B Bellemare M F Hou J Y | 2010 | World Development2010，38，1： | 1 |
| 9 | As you sow, so shall you reap:The welfare impacts of contract farming显示文摘 | Bellemare M F | 2012 | World Development2012，40，7： | 1 |
| 10 | Continuous-wave silica-based erbium-doped fibre lasers显示文摘 | BELLEMARE A | 2003 | Progress in Quantum Electronics2003，27，4： | 1 |
| 11 | Evaluation of human diaphragm function 显示文摘 | Bellemare F | 1993 | Monaldi Arch Chest Dis1993，48，： | 1 |
| 12 | Outdoor tem- perature,age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-de- teeted BAT in humans显示文摘 | Ouellet V Routhier-Labadie A Bellemare W | 2011 | J Clin Endoerinol Metab2011，96，1： | 1 |
| 13 | A natomic landmarks to estimate the length of the diaphragm from chest radiographs:effects of emphysema and lung volume reduction surgery显示文摘 | Bellemare F Couture J Cordeau MP | 2001 | Chest2001，120，2： | 1 |
| 14 | Effect of pressure and timing of contraction on human diaphragm fatigue 显示文摘 | Bellemare F Grassino A | 1982 | J Appl Physiol1982，53，5： | 1 |
| 15 | The dichoto- mous pattern of |L-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation 显示文摘 | Chognard G Bellemare L Pelletier AN | 2014 | Plus one2014，9，89： | 1 |
| 16 | Cloned DNAsequences complementary to mRNAs encoding precursors to thesmall subunit of ribulose-1,5-bisphosphate carboxylase and achlorophyll a/b binding polypeptide显示文摘 | Broglie R Bellemare G Bartlett S G | 1981 | Proc Natl Acad Sci USA1981，78，： | 1 |
| 17 | Reconstruction of the replaced right hepatic artery at the time of pancreaticoduodenectomy 显示文摘 | Allendorf JD Bellemare S | 2009 | J Gastrointest Surg2009，13，3： | 1 |
| 18 | Force reserve of the diaphragm in patients with chronic obstructive pulmonary disease 显示文摘 | Grassino A | 1983 | J Appl Physiol1983，55，1： | 1 |
| 19 | Expression of hyaluronan and the hyaluronan-binding proteoglycans neurocan, aggrecan, and versican by neural stem cells and neural cells derived from embryonic stem cells显示文摘 | Abaskharoun M Bellemare M Lau E | 2010 | Brain Res2010，1327，： | 1 |
| 20 | Agricultural extension and imperfect supervision in contract farming; evidence from Madagascar显示文摘 | Bellemare M F | 2010 | Agricultural Economics2010，，41： | 1 |
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