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| 1 | Analysis of the postoperative hemostatic profile of colorectal cancer patients subjected to liver metastasis resection surgery显示文摘BACKGROUND Liver resection surgery has advanced greatly in recent years,and the adoption of fasttrack programs has yielded good results.Combination anesthesia (general anesthesia associated to epidural analgesia) is an anesthetic-analgesic strategy commonly used for the perioperative management of patients undergoing surgery of this kind,though there is controversy regarding the coagulation alterations it may cause and which can favor the development of spinal hematomas.AIM To study the postoperative course of liver resection surgery,an analysis was made of the outcomes of liver resection surgery due to colorectal cancer metastases in our centre in terms of morbiditymortality and hospital stay according to the anesthetic technique used (general vs combination anesthesia).METHODS A prospective study was made of 61 colorectal cancer patients undergoing surgery due to liver metastases under general and combination anesthesia between January 2014 and October 2015.The patient characteristics,intraoperative variables,postoperative complications,evolution of hemostatic parameters,and stay in intensive care and in hospital were analyzed.RESULTS A total of 61 patients were included in two homogeneous groups: general anesthesia (n = 30) and combination anesthesia (general anesthesia associated to epidural analgesia)(n = 31).All patients had normal coagulation values before surgery.The international normalized ratio (INR) in both the general and combination anesthesia groups reached maximum values at 2448 h (mean 1.37 and 1.45 vs 1.39 and 1.41,respectively),followed by a gradual decrease.There was less intraoperative bleeding in the combination anesthesia group (769 mL) than in the general anesthesia group (1200 mL)(P < 0.05).Of the 61 patients,38.8% in the general anesthesia group experienced some respiratory complication vs 6.6% in the combination anesthesia group (P < 0.001).The time to gastrointestinal tolerance was significantly correlated to the type of anesthesia,though not so the stay in critical care or the time to hospital discharge.CONCLUSION Epidural analgesia in liver resection surgery was seen to be safe,with good results in terms of pain control and respiratory complications,and with no associated increase in complications secondary to altered hemostasis. | Guillermo Perez Navarro Ana Maria Pascual Bellosta Sonia María Ortega Lucea Mario Serradilla Martín Jose Manuel Ramirez Rodriguez Javier Martinez Ubieto | 2019 | World Journal of Clinical Cases2019，7，17： | 4 |
| 2 | Non-lipid-related effects of statins显示文摘 | Bellosta S Ferri N Bernini F | 2000 | Ann Med2000，32，3： | 1 |
| 3 | Non lipid related effects of statins 显示文摘 | Bellosta S Ferri N Bermini F | 2002 | Ann Med2002，32，3： | 1 |
| 4 | Direct vascular effects of HMG-CoA reductase inhibitor显示文摘 | Bernini F Ferri N | 1998 | Atherosclerosis1998，137，： | 1 |
| 5 | HM G2COA reductase inhi-bitons reduce MM P29 secretion by macrophages显示文摘 | Bellosta S V ia D CanavesiM | 1998 | ArteriosclerThromb Vasc biol1998，18，： | 1 |
| 6 | Anti-atherothrombotic and anti-inflammatory properties of rosuvastatin in ApoE-deficient mice显示文摘 | Canavesi M Monetti M | 2004 | Arterioscler Thromb Vasc Biol2004，24，： | 1 |
| 7 | Direct vascular effects of HMG-CoA reductase inhibitors显示文摘 | Bellosta S Bernini F Ferri N | 1998 | Atherosclerosis1998，，： | 1 |
| 8 | Pharmacology of the new p2y12 receptor inhibitors: insights on pharmacokinetic and pharmacody- namic properties显示文摘 | Ferri N Corsini A Bellosta S | 2013 | Drugs2013，73，15： | 1 |
| 9 | Direct vascular effects of HMG-CoA reductase inhibitors显示文摘 | Bellosta S Bernini F Ferri N | 1998 | Atherosclerosis1998，137，： | 1 |
| 10 | New insights into the pharmaeodynamie and pharmacokinetic properties of statins 显示文摘 | CORSINI A BELLOSTA S BAETTA R | 1999 | Pharmaeol Ther1999，84，3： | 1 |
| 11 | HM G2COA reductase inhibitons reduce MM P29 secretion by macrophages显示文摘 | Bellosta S Via D Canavesi M | | 0，，： | 1 |
| 12 | Safety considerations for statins显示文摘 | Bolego C Baetta R Bellosta S | 2002 | Curr Opin Lipidol2002，13，6： | 1 |
| 13 | Pleiotropic effects of statins inatheros clerosis and diabetes 显示文摘 | Bellosta S Ferri N Amaboldi L | 2000 | Diabetes Care2000，23，2： | 1 |
| 14 | Lithium bistriflu-oromethanesulfonimidate-mediated regioselective ring o-pening of aziridines by amines 显示文摘 | Cossy J Bellosta V Alauze V | 2002 | Synthesis2002，，15： | 1 |
| 15 | The Inhibitory Effect of Apolipoprotein E4 on Neurite Outgrowth Is Associated with Microtubule Depolymerization显示文摘 | Britto P Kung-Ching Chang Stefano Bellosta | 1995 | J Biol Chem1995，270，19： | 1 |
| 16 | Pleiotropic effects of statins in atherosclerosis and diabetes 显示文摘 | Bellosta S Ferri N Arnaboldi L | 2000 | Diabetes Care2000，23，2： | 1 |
| 17 | Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts显示文摘 | Mansukhani A Bellosta P Sahni M | 2000 | J Cell Biol2000，149，6： | 1 |
| 18 | Pleiotropic effects of statins in atherosclerosis and diabetes显示文摘 | Bellosta S Ferri N Arnaboldi L | 2000 | Diabetes Care2000，23，2： | 1 |
| 19 | Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration显示文摘 | Buttini M Orth M Bellosta S | 1999 | J Neurosci1999，19，12： | 1 |
| 20 | Direct vascular effeets of HMA-COA reductase inhibitors显示文摘 | Bellosta S Bernini F Ferri N | 1998 | Atherosclerosis1998，，： | 1 |
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