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| 1 | Alternative splicing as a biomarker and potential target for drug discovery显示文摘其他的拼接在 pre-mRNA 成熟期间是 multi-exonic 基因表示的一个关键过程。在这个过程,基因的特别 exons 将被包括在以内或从最后的成熟 mRNA,和产生抄本排除了产生多样的蛋白质 isoforms。最近的证据证明有多重 exons 的约 95% 人的基因经历在 pre-mRNA 成熟期间的其他的拼接。因此,其他的拼接在生理的进程和房间开发程序起一个关键作用,其他的拼接的 and.dysregulation 高度与人的疾病被联系例如癌症,糖尿病和 neurodegenerative 疾病。在这评论,我们讨论其他的拼接的规定,检验在其他的拼接和人的疾病之间的关系,并且描述修改其他的拼接的几条途径,它能帮助人的疾病诊断和治疗。 | Kai-qin LE Bellur S PRABHAKAR Wan-jin HONG Liang-cheng LI | 2015 | Acta Pharmacologica Sinica2015，36，10： | 4 |
| 2 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 3 | A Taxonomy of QoS- aware, Adaptive Event-dissemination Middleware显示文摘 | Mahambre S P Kumar M Bellur U | 2007 | IEEE Internet Computing2007，11，4： | 1 |
| 4 | Photochemical rearrangement of ot-chloro-propio- phenones to a-arylpropanoic acids: Studies of chirality transfer and synthesis of (S)-( + )-ibuprofen and (S)- ( + ) -ketoprofen 显示文摘 | Sonawane Harikisan Bellur Nanjundiah S Kulkami Dilip G | 1994 | Tetrahedron1994，50，4： | 1 |
| 5 | Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs显示文摘 | Zhao C Bellur DL Lu S | 2009 | Am JHum Genet2009，85，5： | 1 |
| 6 | Validation of the Oxford classification of IgA nephropathy in cohorts with different presenta- tions and treatments显示文摘 | Coppo R Troyanov S Bellur S | 2014 | Kidney Int2014，86，4： | 1 |
| 7 | Validation of the Ox- ford classification of IgA nephropathy in cohorts with dif- ferent presentations and treatments 显示文摘 | Coppo R Troyanov S Bellur S | 2014 | Kidney Int2014，86，4： | 1 |
| 8 | Validation of the Oxford classifi- cation of IgA nephropathy in cohorts with different presentations and treatmants显示文摘 | Coppo R Troyanov S Bellur S | 2014 | Kidney international2014，86，4： | 1 |
| 9 | Immunostain-ing findings in IgA nephropathy:correlation with his-tology and clinical outcome in the Oxford classifica-tion patient cohort显示文摘 | Bellur S S Troyanov S Cook H T | 2011 | Nephrology Dialysis Transplan tation2011，26，： | 1 |
| 10 | Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments显示文摘 | Coppo R Troyanov S Bellur S | 2014 | Kidney Int2014，86，4： | 1 |
| 11 | Immunostaining findings in IgA nephropathy: colTelation with histology and clinical outcome in the Oxford classification patient cohort显示文摘 | Bellur SS Troyanov S Cook HT | 2011 | Nephrol Dial Transplant2011，26，8： | 1 |
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