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| 1 | Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension显示文摘AIM: To study the mechanism involved in the potentially beneficial effect of ultra low dose aspirin (ULDA) in prehepatic portal hypertension, rats were pretreated with selective COX 1 or 2 inhibitors (SC-560 or NS-398 respectively), and subsequently injected with ULDA or placebo. METHODS: Portal hypertension was induced by portal vein ligation. Platelet activity was investigated with an in-vivo model of laser induced thrombus production in mesenteric circulation and induced hemorrhagic time (IHT). Platelet aggregation induced by ADP and dosing of prostanoid products 6-keto-PGF1α, TXB2, PGE2 and LTB4 were also performed. RESULTS: The portal hypertensive group receiving a placebo showed a decreased in vivo platelet activity with prolonged IHT, an effect that was normalized by ULDA. SC-560 induced a mild antithrombotic effect in the normal rats, and an unmodified effect of ULDA. NS-398 had a mild prothrombotic action in portal hypertensive rats, similar to ULDA, but inhibited a further effect when ULDA was added. An increased 6-keto-PGF1α was observed in portal hypertensive group that was normalised after ULDA administration. TXA2 level after ULDA, remained unchanged. CONCLUSION: These results suggest that the effect of ULDA on platelet activity in portal hypertensive rats, could act through a COX 2 pathway more than the COX 1, predominant for aspirin at higher doses. | Francisco X Eizayaga Omar Aguejouf Vanessa Desplat Philippe Belon Christian Doutremepuich | 2007 | World Journal of Gastroenterology2007，13，38： | 4 |
| 2 | Electrocomposite a new opportunity for metal finishers 显示文摘 | Archibald L C E Belon P R | 1992 | Metal Finishing1992，90，2： | 1 |
| 3 | Gaint Room-Temperature Magnetostrictions in TbFe2 and DyFe2显示文摘 | Clark A E Belon H S | 1972 | Physical Review1972，5，9： | 1 |
| 4 | Modulation of signal proteins:a plausible mechanism to explain how a potentized drug Secale Cor 30C diluted beyond Avogadro's limit combats skin papilloma in mice显示文摘 | Khuda-Bukhsh AR Bhattacharyya SS Paul S Dutta S Boujedaini N Belon P | | 0，，： | 1 |
| 5 | Preliminary results of a phase Ⅱ study to evaluate gefitinib combined with doeetaxel and cisplatin in patients with recurrent and/or metastatic squmous-cell carcinoma of the head and neck显示文摘 | BELON J IRIGOYEN A RODRIGUEZ I | 2005 | Proc Am Soc Clin Oncol2005，23，： | 1 |
| 6 | Molecular analysis of the androgen receptoe gene in 52 patients with complete or partial androgen insensitivity syndrome:a collaborative study显示文摘 | Belon C Chaussain Jl | 1992 | Horm Res1992，37，12： | 1 |
| 7 | Gaint room-temperature magnetostrictions in TbFe2 and DyFe: 显示文摘 | Clark A E Belon H S | 1972 | Physical Review1972，5，9： | 1 |
| 8 | A method for the determination of type 1 iodothyronine deiodinase activity in liver and kidney using ^125I-labelled reverse triiodothyronine as a substrate显示文摘 | Hotz CS Belon JEB Fitzpatrick DW | 1996 | Clin Biochem1996，9，： | 1 |
| 9 | Selfreported diabetes in the elderly: prevalence, associated factors, and control practices 显示文摘 | Francisco PM Belon AP Barros MB | 2010 | Cad Saude Publica2010，26，1： | 1 |
| 10 | Pentoxifylline as- sociated to hypertonic saline solution attenuates inflammatory process and apoptosis after intestinal ischemia/reperfusion in rats显示文摘 | Marques GM Rasslan R Belon AR | 2014 | Aeta Cir Bras2014，29，11： | 1 |
| 11 | Heterogeneous effects of B7-1 and B7-2 in the induction of both protective and therapeutic anti-tumor immunity against different mouse tumors 显示文摘 | Martin-Fontecha A Cavallo F Belone M | 1996 | EurJ Immunol1996，26，8： | 1 |
| 12 | Preliminary results of a phase Ⅱ study to evaluate gefitinib combined with docetaxel and cisplatin in patients with recurrent and/or metastatic squamous - cell carcinoma of the head and neck 显示文摘 | Belon J Irigoyen A Redriguez I | 2005 | J Clin Oncol2005，23，： | 1 |
| 13 | Radical prostatectomy as monotherapy for locally advanced prostate cancer (T3a): 12 years' follow-up显示文摘 | Isorna S Belon J Marrero R | 2004 | Arch Esp Urol2004，57，： | 1 |
| 14 | Genes of the Y chromosome and Turner syndrome 显示文摘 | LOBACCARO J M LUMBROSO S BELON C | 1994 | Ann Endocrinol (Paris)1994，54，5： | 1 |
| 15 | Effects of ischemic preeonditioning in a pig model of large-for-size liver transplantation显示文摘 | Leal AJ Tannuri AC Belon AR | 2015 | Clinics (Sao Paulo)2015，70，2： | 1 |
| 16 | The association ofBecker nevus with hypersensitivity to androgens 显示文摘 | Nirde P Dereure 0 Belon C | 1999 | Arch Dermatol1999，135，2： | 1 |
| 17 | Enterocyte damage in critically ill patients is associated with shock condition and 28-day mortality显示文摘 | Piton G Belon F Cypriani B | 2013 | Crit Care Med2013，41，9： | 1 |
| 18 | Myasthenia gravis and its ex- perimental model显示文摘 | Conti FB Protti M Belone M | 1996 | The immunobiology of all autoimmune disease1996，3，4： | 1 |
| 19 | Preliminary results of a Phase Ⅱ study to evaluate ge?tinib combined with docetaxel and cisplatin in patients with recurrent and/or metastatic squamous-cell carcinoma of the head and neck显示文摘 | Belon J Irigoyen A Rodriguez I | 2005 | Proc Am Soc Clin Oncol2005，23，： | 1 |
| 20 | Radical prostatectomy as monotherapy for locally advanced prostate cancer (T3a): 12 years follow-up显示文摘 | ISORNA MARTINEZ DE LA RIVA S BELON LOPEZ-TOMASETY J MARRERO DOMINGUEZ R | 2004 | Arch Esp Urol2004，57，7： | 1 |
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