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9篇 您的检索式:作者名="Ben RA"
    题名 作者 年代 出处 被引量
1Evaluation of the Sysmex UF-100 automated urinalysis analyzer 显示文摘Ben Ezra J Bork L McPherson RA 1998Clin Chem1998,44,1:1
2Volatile fatty acids,lactic acid,and ph in the stools of breast-fed and bottle-fed infants显示文摘Ogawa K Ben RA Pons S 1992J Pediatr Gastroenterol Nutr1992,15,:1
3Transmission analysis of OFDM - Based wireless services over turbulent Radio - on - FSO links modeled by Gamma-Gamma distribution显示文摘Abdelmoula Bekkali Chedlia Ben Naila Kamugisha Kazau- ra 2010IEEE Photonics Journal2010,2,3:1
4Sleep and psychiatric disorder显示文摘Ben RM Obermeyer WH Thiated RA 1992Arc Gen Psychiatry1992,49,:1
5The signals and pathways activating cellular senescence 显示文摘Ben - Porath I Weinberg RA 2005International Journal of Biochemistry and Cell Biology2005,37,5:1
6A case of pleuropericarditis preceding acute lymphoblastic leukemia显示文摘Zitouna M Kaabar A Ben RA 1984Tunis Med1984,62,2:1
7Evaluation of the Sysmex UF- IO0 automated urinalysis analyzer 显示文摘Ben - Ezra J Bork L McPherson RA 1998ClinChem1998,44,1:1
8The signals and pathways activating cellular senescence 显示文摘Ben - Porath I Weinberg RA 2005Int J Biochem Cell Biol2005,37,5:1
9Loss of efficacy and safety of the switch from infliximab original to infliximab biosimilar(CT-P13)in patients with inflammatory bowel disease显示文摘BACKGROUND Infliximab original has changed the natural history of inflammatory bowel diseases(IBD) over the past two decades. However, the recent expiration of its patent has allowed the entry of the first Infliximab biosimilar into the European and Spanish markets. Currently switching drugs data in IBD are limited. AIM To compare the efficacy of infliximab biosimilar, CT-P13, against infliximab original, analyzing the loss of response of both at the 12 mo follow-up in patients with IBD.METHODS An observational study of two cohorts has been conducted. One retrospective cohort that included patients with IBD treated with Infliximab original, and a prospective cohort of patients who were switching from infliximab original to infliximab biosimilar(CT-P13). We had analyzed the overall efficacy and loss of efficacy in patients in remission at the end of one year after treatment with the original drug compared to the results of the year of treatment with the biosimilar.RESULTS98 patients(CD 67, CU 31) were included in both cohorts. The overall efficacy for infliximab original per year of treatment was 71% vs 68.2% for infliximab biosimilar(P = 0.80). The loss of overall efficacy at 12 mo for infliximab original was 6.6% vs 14.5% for infliximab biosimilar(P = 0.806). The loss of efficacy in patients who were in basal remission was 16.3% for infliximab original vs 27.1% for infliximab biosimilar. Adverse events were 9.2% for infliximab original vs 11.2% for infliximab biosimilar. CONCLUSION The overall efficacy and loss of treatment response with infliximab biosimilar(CT-P13) is similar to that observed with infliximab original in patients who were switching at the 12 mo follow-up. There is no difference in the rate of adverse events.María Fernanda Guerra Veloz Federico Argüelles-Arias Luisa Castro Laria Belén Maldonado Pérez Antonio Benítez Roldan Raúl Perea Amarillo Vicente Merino Bohórquez Miguel Angel Calleja Angel Caunedo Alvarez Angel Vilches Arenas 2018World Journal of Gastroenterology2018,24,46:0
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