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| 1 | Unraveling the dose-response puzzle of L.monocytogenes:A mechanistic approach显示文摘Food-borne disease outbreaks caused by Listeria monocytogenes continue to impose heavy burdens on public health in North America and globally.To explore the threat L.monocytogenes presents to the elderly,pregnant woman and immuno-compromised individuals,many studies have focused on in-host infection mechanisms and risk evaluation in terms of dose-response outcomes.However,the connection of these two foci has received little attention,leaving risk prediction with an insufficient mechanistic basis.Consequently,there is a critical need to quantifiably link in-host infection pathways with the doseresponse paradigm.To better understand these relationships,we propose a new mathematical model to describe the gastro-intestinal pathway of L.monocytogenes within the host.The model dynamics are shown to be sensitive to inoculation doses and exhibit bistability phenomena.Applying the model to guinea pigs,we show how it provides useful tools to identify key parameters and to inform critical values of these parameters that are pivotal in risk evaluation.Our preliminary analysis shows that the effect of gastroenvironmental stress,the role of commensal microbiota and immune cells are critical for successful infection of L.monocytogenes and for dictating the shape of the doseresponse curves. | S.M.Ashrafur Rahman Daniel Munther Aamir Fazil Ben Smith Jianhong Wu | 2016 | Infectious Disease Modelling2016，1，1： | 2 |
| 2 | Three-dimensional structure of myosin subfragment-1 : a molecular motor显示文摘 | Rayment I Rypniewski WR Schmidt-Base K Smith R Tomchik DR Benning MM Winkelmann DA Wesenberg G Holden HM | 1993 | Science1993，261，： | 1 |
| 3 | Decision trees for uncertain data显示文摘 | Smith Tsang Ben Kao Kevin Y YIP | | 0，，01： | 1 |
| 4 | Management Succession and Financial Performance of Family Controlled Firms显示文摘 | Brian F Smith Ben A | 1999 | Journal of Corporate Finance1999，，： | 1 |
| 5 | Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators显示文摘 | George P. Lahm Thomas P. Selby John H. Freudenberger Thomas M. Stevenson Brian J. Myers Gilles Seburyamo Ben K. Smith Lindsey Flexner Christopher E. Clark Daniel Cordova | 2005 | Bioorganic & Medicinal Chemistry Letters2005，，22： | 1 |
| 6 | Cortisol, testosterone,and coronary heart disease : prospective evidence from the Caerphillystudy显示文摘 | Smith GD Ben - Shlomo Y Beswick A | 2005 | Circulation2005，112，3： | 1 |
| 7 | 成功招聘的五大策略显示文摘如何从一大堆简历中挑选出合适的人才?如何将合适的人才与合适的职位一一对应?本文为您介绍了五条简单有效的策略,助您轻松掌控整个招聘过程。 | Ben Smith 黄思维(译) | 2006 | Windows IT Pro Magazine(国际中文版)2006，，1： | 1 |
| 8 | Soil-atmo-sphere exchange of carfx?n dioxide,methane and nitrous oxide in ur-ban garden systems:impact of irrigation,fertiliser and mulch显示文摘 | Stephen J Livesley Ben J Dougherty Alison J Smith | 2010 | UAan Ecosystems2010，，3： | 1 |
| 9 | In Situ and In Vitro Gene Expression by Vibrio vulnificus during Entry into,Persistence within, and Resuscitation from the Viable but Nonculturable State 显示文摘 | Ben Smith James D Oliver | 2006 | Applied and Environmental Microbiology Feb2006，，： | 1 |
| 10 | Defining a prognostic marker panel for patients with ovarian serous carcinoma effusions显示文摘 | Ben Davidson Yoav Smith Jahn M. Nesland Janne K?rn Reuven Reich Claes G. Tropè | 2013 | Human Pathology2013，，： | 1 |
| 11 | Use of benzodiazepines and selective serotonin reuptake inhibitors in middle-aged and older adults with anxiety disorders:a longitudinal and prospective study显示文摘 | Benítez CI Smith K Vasile RG | 2008 | Am J Geriatr Psychiatry2008，16，1： | 1 |
| 12 | In Situ Gene Expression by Vibrio vulnificus 显示文摘 | Ben Smith James D Oliver | 2006 | Applied and environmental Microbiology2006，，： | 1 |
| 13 | Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators显示文摘 | George P. Lahm Thomas P. Selby John H. Freudenberger Thomas M. Stevenson Brian J. Myers Gilles Seburyamo Ben K. Smith Lindsey Flexner Christopher E. Clark Daniel Cordova | 2005 | Bioorganic & Medicinal Chemistry Letters2005，，22： | 1 |
| 14 | Decision Trees For Uncertain Data 显示文摘 | Smith Tsang Ben Kao Kevin Y | 2011 | IEEE transactions on knowledge and data engineering2011，，1： | 1 |
| 15 | Dieulafoy's diseaseof the bronchus :a rare cause of massive hemoptysis 显示文摘 | Ben Smith David Hart Naveed Alam | 2014 | Respirol Case Rep2014，2，2： | 1 |
| 16 | Genome-wide transcript analysis of maize hybrids: allelic additive gene expression and yield heterosis显示文摘 | Mei Guo Mary A. Rupe Xiaofeng Yang Oswald Crasta Christopher Zinselmeier Oscar S. Smith Ben Bowen | 2006 | Theoretical and Applied Genetics2006，，5： | 1 |
| 17 | Experimental and numerical investigations of the deformation of soft materials under tangential loading显示文摘 | BEN X J SMITH C W EVANS K E | 2006 | International Journal of Solids & Structures2006，43，7： | 1 |
| 18 | Vitamin D supplementation to reduce depression in adult: Meta-analysis of randomized controlled trials显示文摘 | Usha Gowda Mutsa P. Mutowo Ben J. Smith Anita E. Wluka Andre M.N. Renzaho | 2014 | Nutrition2014，，： | 1 |
| 19 | Executive compensation in firms with concentrated control: The impact of dual class structure and family management显示文摘 | Ben Amoako-Adu Vishaal Baulkaran Brian F. Smith | 2011 | Journal of Corporate Finance2011，，5： | 1 |
| 20 | A comparision of winged steel needle and Telflon cannulas in maintaining intravenous access during gastrointestinal endoscopy显示文摘 | Smith MR Ben GD | 1993 | Gostrointest Endose1993，39，1： | 1 |
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