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| 1 | PNPLA3 I148M polymorphism and progressive liver disease显示文摘The 148 Isoleucine to Methionine protein variant(I148M)of patatin-like phospholipase domain-containing 3(PNPLA3),a protein is expressed in the liver and is involved in lipid metabolism,has recently been identified as a major determinant of liver fat content.Several studies confirmed that the I148M variant predisposes towards the full spectrum of liver damage associated with fatty liver:from simple steatosis to steatohepatitis and progressive fibrosis.Furthermore,the I148M variant represents a major determinant of progression of alcohol related steatohepatitis to cirrhosis,and to influence fibrogenesis and related clinical outcomes in chronic hepatitis C virus hepatitis,and possibly chronic hepatitis B virus hepatitis,hereditary hemochromatosis and primary sclerosing cholangitis.All in all,studies suggest that the I148M polymorphism may represent a general modifier of fibrogenesis in liver diseases.Remarkably,the effect of the I148M variant on fibrosis was independent of that on hepatic steatosis and inflammation,suggesting that it may affect both the quantity and quality of hepatic lipids and the biology of non-parenchymal liver cells besides hepatocytes,directly promoting fibrogenesis.Therefore,PNPLA3 is a key player in liver disease progression.Assessment of the I148M polymorphism will possibly inform clinical practice in the future,whereas the determination of the effect of the 148M variant will reveal mechanisms involved in hepatic fibrogenesis. | Paola Dongiovanni Benedetta Donati Roberta Fares Rosa Lombardi Rosellina Margherita Mancina Stefano Romeo Luca Valenti | 2013 | World Journal of Gastroenterology2013，19，41： | 17 |
| 2 | Analysis of gene environment interaction in coronary heart disease:fibrinogen polymorphisms as an example显示文摘 | Michela Vischetti Francesco Zito Maria Benedetta Donati Licia Iacoviello | 2002 | Ital Heart J2002，3，： | 1 |
| 3 | Angiogenesis and the progress of vascular and tumor biology:a tribute to Judah Folkman显示文摘 | Benedetta Donati M Gozdzikiewicz J | 2008 | Thromb Haemost2008，99，4： | 1 |
| 4 | Platelet glycoprotein Ⅱb/Ⅲa polymorphism and coronary artery disease:implications for clinical practice显示文摘 | di Castelnuovo A de Gaetano G Benedetta Donati M | 2005 | Am J Pharmacogenomics2005，5，2： | 1 |
| 5 | Patatin‐like phospholipase domain‐containing 3 I148M affects liver steatosis in patients with chronic hepatitis B显示文摘 | Mauro Viganò Luca Valenti Pietro Lampertico Floriana Facchetti Benedetta Maria Motta Roberta D’Ambrosio Solange Romagnoli Paola Dongiovanni Benedetta Donati Silvia Fargion Massimo Colombo | 2013 | Hepatology2013，，4： | 1 |
| 6 | The ?174G/C Interleukin-6 Polymorphism Influences Postoperative Interleukin-6 Levels and Postoperative Atrial Fibrillation. Is Atrial Fibrillation an Inflammatory Complication?显示文摘 | Mario Gaudino Felicita Andreotti Roberto Zamparelli Augusto Di Castelnuovo Giuseppe Nasso Francesco Burzotta Licia Iacoviello Maria Benedetta Donati Rocco Schiavello Attilio Maseri Gianfederico Possati | 2003 | Circulation: Journal of the American Heart Association . 2003 (10 S)2003，，： | 1 |
| 7 | Platelet glycoprotein Ⅱb/Ⅲa polymorphism and coronary artery disease:implications for clinical practice显示文摘 | Di Castelnuovo A de Gaetano G Benedetta Donati M | 2005 | Am J Pharmacogenomics2005，5，2： | 1 |
| 8 | A 4-Polymorphism Risk Score Predicts Steatohepatitis in Children With Nonalcoholic Fatty Liver Disease显示文摘 | Valerio Nobili Benedetta Donati Nadia Panera Apirom Vongsakulyanon Anna Alisi Bruno Dallapiccola Luca Valenti | 2014 | Journal of Pediatric Gastroenterology and Nutrition2014，，5： | 1 |
| 9 | Platelet glycoprotein Ⅱ b/Ⅲ a polymorphism and coronary artery disease: implications for clinical practice 显示文摘 | Castelnuovo A Di Gaetano G de Benedetta Donati M | 2005 | Am J Pharmacogenomics2005，5，2： | 1 |
| 10 | Prevention of postoperative atrial fibrillation in open heart surgery patients by preoperative supplementation of n-3 polyunsaturated fatty acids: An updated meta-analysis显示文摘 | Simona Costanzo Veronica di Niro Augusto Di Castelnuovo Francesco Gianfagna Maria Benedetta Donati Giovanni de Gaetano Licia Iacoviello | 2013 | The Journal of Thoracic and Cardiovascular Surger2013，，： | 1 |
| 11 | Pathogenesis of thrombosis in patients with malignancy显示文摘 | Anna Falanga Maria Benedetta Donati | 2001 | International Journal of Hematology2001，，2： | 1 |
| 12 | Analysis of gene environment interaction in coronary heart disease : fibrinogen polymorphisms as an example显示文摘 | Michela Vischetti Franeesco Zito Maria Benedetta Donati | 2002 | hal Heart J2002，3，1： | 1 |
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