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| 1 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 2 | Valuing informal recreation on the forestry commission estate显示文摘 | Willis K G | 1993 | Quarterly Journal of Forestry1993，16，3： | 1 |
| 3 | MAPK pathways activate and phosphorylate the osteoblast - specific transcription factor, Cbfa1 显示文摘 | Xiao G Jiang D Thomas P Benson MD | 2000 | J BiolChem2000，275，6： | 1 |
| 4 | Valuing informal recreation on the forestry commission estate显示文摘 | Benson J F、Wills K G | 1993 | Quarterly Journal of Forestry1993，16，3： | 1 |
| 5 | Optical coherence tomography analysis of the macula after scleral buckle surgery for retional detachment 显示文摘 | BENSON S E SCHLOTTMANN P G BUNCE C etal | 2007 | Ophthalmology2007，114，1： | 1 |
| 6 | Development and verification of the proximal/marginal plaque index显示文摘 | Benson BJ Henyon G Grossman E | 1993 | J Clin Dent1993，4，： | 1 |
| 7 | Performance-based design of landfill liners 显示文摘 | Katsumi T Benson C H Foose G J | 2001 | Eng Geology2001，60，： | 1 |
| 8 | Three-to six-year follow-up of stand-alone BAK cages implanted by a single surgeon 显示文摘 | Button G Gupta M Barrett C Cammack P Benson D | 2005 | Sline J2005，5，： | 1 |
| 9 | Chromic mechanism in amorphous WO3films显示文摘 | Zhang J G Benson D K Tracy C E | 1997 | Electrochem Soc1997，144，： | 1 |
| 10 | Process for conver-ting hydrogen chloride to chlorine 显示文摘 | PanH Y Minet R G Benson S W | 1994 | Industrial & Engi-neering Chemistry Research1994，33，12： | 1 |
| 11 | Direct trajectory optimization and eostate estimation via an orthogohal collocation method 显示文摘 | Benson D A Huntington G T Thorvaldsen T P Rao A V | 2006 | Journal of Guidance Control and Dynamics2006，29，6： | 1 |
| 12 | Sulfamic acid and its N-substituted derivatives显示文摘 | Benson G A Sillane W J | 1980 | Chem Rev1980，80，2： | 1 |
| 13 | Direct trajectory optimization and costate estimation via an orthogonal collocation method 显示文摘 | Benson D A Hunting Ton G T Thorvaldsen T P | 2006 | Journal of Guidance Control and Dynamics2006，29，6： | 1 |
| 14 | Ipsilateral Iocal recur- rence of breast cancer, determinant or indicator of poor prognosis? 显示文摘 | Querci della Rovere G Benson JR | 2002 | Lancet 0ncol2002，3，： | 1 |
| 15 | Sexually dimorphic sterility phe- notypes in Hoxal0-deficientmice显示文摘 | Satakata I Benson G Maas R | 1995 | Nature1995，374，6521： | 1 |
| 16 | Tandem Repeats Finder:A Program to Analyze DNA Sequences显示文摘 | Benson G | 1999 | Nucleic Acids Research1999，27，2： | 1 |
| 17 | Wisteria floribunda lectin is associated with specific cell types in the ventral cochlear nucleus of the gerbil, Meriones unguiculatus 显示文摘 | Cant N B Benson C G | 2006 | Hearing Research2006，6，216： | 1 |
| 18 | Exaggerated heart rate oscillations during two meditation techniques 显示文摘 | Peng C-K and Mietus J E and Liu Y and Khalsa G and Douglas P S and Benson H and Goldberger A L | 1999 | Int J Cardiol:1999，70，： | 1 |
| 19 | Strategies to prevent re- straint-related deaths显示文摘 | Benson R Miller G Rogers P | 2012 | Ment Health Pract2012，15，7： | 1 |
| 20 | Coherent interaction of atoms with a beam of light confined in a light cage显示文摘Controlling coherent interaction between optical fields and quantum systems in scalable,integrated platforms is essential for quantum technologies.Miniaturised,warm alkali-vapour cells integrated with on-chip photonic devices represent an attractive system,in particular for delay or storage of a single-photon quantum state.Hollow-core fibres or planar waveguides are widely used to confine light over long distances enhancing light-matter interaction in atomic-vapour cells.However,they suffer from inefficient filling times,enhanced dephasing for atoms near the surfaces,and limited light-matter overlap.We report here on the observation of modified electromagnetically induced transparency for a non-diffractive beam of light in an on-chip,laterally-accessible hollow-core light cage.Atomic layer deposition of an alumina nanofilm onto the light-cage structure was utilised to precisely tune the high-transmission spectral region of the light-cage mode to the operation wavelength of the atomic transition,while additionally protecting the polymer against the corrosive alkali vapour.The experiments show strong,coherent light-matter coupling over lengths substantially exceeding the Rayleigh range.Additionally,the stable non-degrading performance and extreme versatility of the light cage provide an excellent basis for a manifold of quantum-storage and quantumnonlinear applications,highlighting it as a compelling candidate for all-on-chip,integrable,low-cost,vapour-based photon delay. | Flavie Davidson-Marquis Julian Gargiulo Esteban Gómez-López Bumjoon Jang Tim Kroh Chris Müller Mario Ziegler Stefan A.Maier Harald Kübler Markus A.Schmidt Oliver Benson | 2021 | Light(Science & Applications)2021，10，7： | 1 |
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