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| 1 | Association of ABO blood group and Plasmodium falciparum malaria in Dore Bafeno Area,Southern Ethiopia显示文摘Objective:To assess the distribution of ABO blood group and their relationship with Plasmodium falciparum(P.falciparum) malaria among febrile outpatients who sought medical attention at Dore Bafeno Health Center,Southern Ethiopia.Methods:A total of 269 febrile outpatients who visited Dore Bafeno Health Center,Southern Ethiopia,were examined for malaria and also tested for ABO blood groups in January 2010.The blood specimens were collected by finger pricking,stained with Geimsa,and examined microscopically.Positive cases of the parasitemia were counted.CareStart^(TM) Malaria PflPv Combo was also used to test the blood specimens for malaria.ABO blood groups were determined by agglutination test using ERYCLONE antisera.Data on socio-demographic characteristics and treatment status of the participants were also collected.Chi-square and ANOVA tests were used to assess the difference between frequencies and means,respectively.Results:Out of a total of 269 participants,178(66.2%) febrile patients were found to be infected with Plasmodium parasites,among which 146(54.3%),28(10.4%),and 4(1.5%) belonged to P.falciparum,P.vivax,and mixed infections,respectively.All febrile patients were also tested for ABO blood groups and 51.3%,23.5%,21.9%and 3.3%were found to be blood types of 0,A,B and AB,respectively.Both total malaria infection and P.falciparum infection showed significant association with blood types(P<0.05).The proportion of A or B but not 0 phenotypes was higher(P<0.05) in individuals with P.falciparum as compared with non-infected individuals.The chance of having P.falciparum infection in patients with blood groups A,B and AB was 2.5,2.5 and 3.3times more than individuals showing blood 0 phenotypes,respectively.The mean P.falciparum malaria parasitemia for blood groups A,B,AB,and 0 were 3 744/μ L,1 805/ μ L,5 331/μ L,and1 515/μ L,respectively(P<0.01).Conclusions:The present findings indicate that individuals of blood groups A,B and AB are more susceptible to P.falciparum infection as compared with individuals of blood group O.Nevertheless,further in depth studies are required to clearly establish the role that ABO blood group plays in P.falciparum malaria. | Tewodros Zerihun Abraham Degarege Berhanu Erko | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 10 |
| 2 | Combined antibacterial activity of stingless bee(Apis mellipodae)honey and garlic(Allium sativum)extracts against standard and clinical pathogenic bacteria显示文摘Objective:To investigate the synergic antibacterial activity of garlic and tazma honey against standard and clinical pathogenic bacteria.Methods:Antimicrobial activity of tazma honey,garlic and mixture of them against pathogenic bacteria were determined.Chloramphenicol and water were used as positive and negative controls,respectively.Minimum inhibitory concentration(MIC)and minimum bactericidal concentration of antimicrobial samples were determined using standard methods.Results:Inhibition zone of mixture of garlic and tazma honey against all tested pathogens was significantly(P≤0.05)greater than garlic and tazma honey alone.The diameter zone of inhibition ranged from(18±1)to(35±1)mm for mixture of garlic and tazma honey,(12±1)to(20±1)nun for tazma honey and(14±1)to(22±1)mm for garlic as compared with(10±1)to(30±1)mm for chloramphenicol.The combination of garlic and tazma honey(30-35 mm)was more significantly(P≤0.05)effective against Salmonella(NCTC 8385),Staphylococcus aureus(ATCC 25923),Lyesria moncytogenes(ATCC 19116)and Streptococcus pneumonia(ATCC 63).Results also showed considerable antimicrobial activity of garlic and tazma honey.MIC of mixture of garlic and tazma honey at 6.25%against total test bacteria was 88.9%.MIC of mixture of garlic and tazma honey at6.25%against Gram positive and negative were 100%and 83.33%,respectively.The bactericidal activities of garlic,tazma honey,and mixture of garlic and tazma honey against all pathogenic bacteria at 6.25%concentration were 66.6%,55.6%and 55.6%,respectively.Conclusions:This finding strongly supports the claim of the local community to use the combination of tazma honey and garlic for the treatment of different pathogenic bacterial infections.Therefore,garlic in combination with tazma honey can serve as an alternative natural antimicrobial drug for the treatment of pathogenic bacterial infections.Further in vivo study is recommended to come up with a comprehensive conclusion. | Berhanu Andualem | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，9： | 4 |
| 3 | Efficacy and side effects of praziquantel in the treatment of Schistosomiasis mansoni in schoolchildren in Shesha Kekele Elementary School,Wondo Genet,Southern Ethiopia显示文摘Objective:To evaluate the efficacy and side effects of praziquantel(PZQ) in the treatment of schistosomiasis in Ethiopia.Methods:In a cross-sectional study,stool specimens were collected from randomly selected 299 school children in Shesha Kekele Elementary School,Wondo Genet, Southern Ethiopia,in April 2010.Stool specimens were examined using a single Kato-Katz thick smear for Schistosoma mansoni(5.mansoni) ova.Children who were found positive for S.mansoni were treated with a single oral dose of PZQ at 40 mg/kg bw and interviewed for treatment-related symptoms 24 hours after drug administration.Four weeks post-treatment,stool specimens were collected from the same children and examined following the same procedure as in the pretreatment.Drug efficacy was determined based on cure and egg reduction rates.Results:Pretreatment prevalence of S.mansoni infection was 74.9%with geometric mean egg count of 268. The evaluated generic PZQ produced an overall cure rate of 73.6%(P<0.000 1,OR:8.33,CI:5.3-13.1) and egg reduction rate of 68.2%(P=0.03,F=0.64).The cure rate showed significant association with age(x^2=H,P=0.004),the highest rate being observed in the 15-22 age group.83%of S. mansoni infected children showed various treatment-related symptoms,the most frerjiient being headache,nausea,and abdominal pain.These symptoms were associated with age(P<0.001) and pre-treatment intensity of infection(P<0.05).Conclusions:The present observations revealed relatively lower cure and egg reduction rates of the PZQ evaluated as compared to previous reports for other PZQ brands in Ethiopia.Hence,in depth studies are recommended to clarify whether the present relatively lower cure rate is the actual cure rate of the praziquantel evaluated,treatment failure,or reduced susceptibility of the parasite.Treatment-related side effects observed were transient and tolerable. | Berhanu Erko Abraham Degarege Konjit Tadesse Asnake Mathiwos Mengistu Legesse | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，3： | 3 |
| 4 | Antimicrobial susceptibility patterns of Streptococcus pneumoniae over 6 years at Gondar University Hospital, Northwest Ethiopia显示文摘Objective:To assess the magnitude and antimicrobial susceptibility patterns ofStreptococcus pneumoniaeisolates from various clinical specimens.Methods:A record based on retrospectivestudy was conducted at Gondar University Teaching Hospital from September 2007 to January 2012.All patients who visited Gondar University Hospital and provided clinical specimens(body fluids,discharge,swab and blood)for routine bacteriological culturing and antimicrobial susceptibilitytesting were taken for analysis.Clinical specimens were processed for bacterial culture accordingto the standard procedures.Antimicrobial susceptibility test for isolated organisms was doneusing agar disk diffusion method.The data were entered and analyzed using SPSS software version16 package.Results:One hundred and fifty threeStreptococcus pneumoniaewere isolated frompatients who visited Gondar University Teaching Hospital bacteriology laboratory for culture.Majority of the pneumococcal isolates were from inpatients[111(72.5%)],and 74(48.4%)were frombody fluids.Out of the total isolates,93(61%)were found to be resistant to at least one antibioticused for susceptibility testing.Forty eight(43.2%)of the isolates were multi-drug resistant(resistantto two or more drugs).The resistance rate noted for both ciprofloxacin 17(11.1%)and ceftriaxone15(9.8%)were alarming.Conclusions:High proportions of the isolates tend to be increasinglyresistant to the commonly prescribed drugs.The recommended drug of choice like ciprofloxacinand ceftriaxone were found to be less susceptible in the study area.Based on the findings,wetherefore recommend that antimicrobial agents should be inspected for acceptable activity beforethey are prescribed and administered empirically.Further study with a better design and surveyof antimicrobial susceptibility at large scale shoule be performed to draw advanced information. | Belay Anagaw Mucheye Gezachew Fantahun Biadgelgene Berhanu Anagaw Tariku Geleshe Birke Taddese Birhanu Getie Mengistu Endris Andargachew Mulu Chandrashekhar Unakal | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，7： | 3 |
| 5 | Seroprevalence of Helicobacter pylori in dyspeptic patients and its relationship with HIV infection,ABO blood groups and life style in a university hospital,Northwest Ethiopia显示文摘瞄准:在消化不良的病人之中决定 Helicobacter pylori (H pylori ) 的流行并且估计在 H pylori 感染,血型, HIV 感染和病人的生活方式之间的关系。方法:在基于医院的代表性的研究, Gondar 医院的大学的病人出席门诊病人部门被注册。Socio 人口统计的信息用问询表被收集。浆液用一个商业工具包为 anti-H pylori IgG 抗体被分析。HIV serostatus 被连接酶的免疫吸着剂试金(ELISA ) 决定。Blood grouping 被幻灯片凝集试验执行。结果:215 个消化不良的病人的一个总数在学习被包括。116 个病人(54%) 是女性,(46%) 99 是男性。Anti-H pylori IgG 抗体在重量的单位被检测一 of 184 (85.6%) 病人。流行在 50 年并且在上面的病人是显著地更高的。百分之五个病人被发现是为 HIV 的血清反应阳性的二十个点。没有重要协会为 H pylori 在性别,土佬血型,香的食谱的消费,社会经济的地位和 seropositivity 之间被发现。然而,白酒消费显著地与 H pylori 血清学被联系。结论:H pylori 感染的流行与白酒吸入和老年的历史被联系。象为 H pylori 感染的风险因素的不同饮食,酒精和社会经济的地位的效果需要进一步的学习。 | Feleke Moges Afework Kassu Getahun Mengistu Solomon Adugna Berhanu Andualem Takeshi Nishikawa Fusao Ota | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 6 | Woody species composition and structure of Kuandisha afromontane forest fragment in northwestern Ethiopia显示文摘To investigate the woody species composition,diversity and structure of Kuandisha Afromontane forest,vegetation and environmental data were collected from 53 plots of 10 m 9 50 m for trees and shrubs and 265 subplots of 2 m 9 4 m for seedlings were laid along eight transect lines. The local name, scientific name, abundance,DBH, height and percentage foliage cover of species were recorded. Environmental variables, namely altitude, latitude and longitude as well as disturbance levels were also recorded in each plot. Structure, basal area, importance value index(IVI) and species prioritization were analyzed using spreadsheet programs. Correlation coefficients, frequency, relative frequency, Shannon diversity index,Shannon evenness and vegetation classification were analyzed using an R package. Sixty-six species belonging to40 families were recorded. Fabaceae was the most diverse family consisting of seven species, followed by Euphorbiaceae and Asteraceae. In terms of habit, 29 species were trees, 28 were shrubs, and 9 were lianas. The overall Shannon diversity index was 2.5. The frequency and relative frequency of woody species with DBH C2.5 cm ranged from 1.9 to 92.5 and 0.1 to 5, respectively. Seedling density varied among species ranging from five to 9938 individuals ha-1. The total basal area of woody species having DBH C2.5 cm is 15.3 m2ha-1. The IVI of species ranged from 0.13 for Solanum giganteum Jacq. to 28.4 for Croton macrostachyus Del. The woody vegetation was classified into five community types. Species richness,diversity and evenness of communities were strongly positively correlated. On the other hand, the correlation between disturbance and seedling density, and species richness was strongly negative. Thus, among the recorded woody species, a significant portion was either lacking regeneration or selectively removed for various purposes.The lack of seedlings of those species is mainly attributed to anthropogenic disturbances particularly free grazing. As a result, 14 tree, seven shrub and one liana species were prioritized for conservation and management interventions. | Abiyot Berhanu Sebsebe Demissew Zerihun Woldu Motuma Didita | 2017 | Journal of Forestry Research2017，28，2： | 2 |
| 7 | Isolation and screening of antibiotic producing actinomycetes from soils in Gondar town, North West Ethiopia显示文摘 | Abebe Bizuye Feleke Moges Berhanu Andualem | 2013 | Asian Pacific Journal of Tropical Disease2013，，5： | 2 |
| 8 | Production of microbial medium from defatted brebra(Milletia ferruginea)seed flour to substitute commercial peptone agar显示文摘Objective:To investigate and optimize microbial media that substitute peptone agar using brebra seed defatted flour.Methods:Defatted process.inoculums preparation,evaluation of bacterial growth,preparation of cooked and hydrolyzed media and growth turbidity of tested bacteria were determined.Results:Two percent defatted flour was found to be suitable concentration for the growth of pathogenic bacteria:Escherichia coli(ATCC 25922)(E,coli),Pseudomonas aeruginosa(ATCC27853),Salmonella(NCTC 8385)and Shigella flexneri(ATCC 12022)(S.flexneri),while 3%defatted flour was suitable for Staphylococcus aureus(ATCC 25923)(S.aureus).E.coli(93±1)and S.flexneri(524±1)colony count were significantly(P≤0.05)greater in defatted flour without supplement than in supplemented medium.E.coli[(3.72×10~9±2)CFU/mL],S.aureus[(7.4×10~9±2)CFU/mL],S.flexneri[(4.03×10~9±2)CFU/mL]and Salmonella[(2.37×10~9±1)CFU/mL]in non-hydrolyzed sample were statistically(P≤0.05)greater than hydrolyzed one and commercial peptone agar.Colony count of Salmonella[(4.55≤10~9±3)CFU/mL],S.flexneri[(5.40≤10~9±3)CFU/mL]and Lyesria moncytogenes(ATCC 19116)[(5.4×10~9±3)CFU/mL]on raw defatted flour agar was significantly(P≤0.05)greater than cooked defatted flour and commercial peptone agar.Biomass of E.coli,S.aureus.Salmonella and Enterococcus faecalis in non-hydrolyzed defatted flour is highly increased over hydrolyzed defatted flour and commercial peptone broth.Conclusions:The defatted flour agar was found to be better microbial media or comparable with peptone agar.The substances in it can serve as sources of carbon,nitrogen,vitamins and minerals that are essential to support the growth of microorganisms without any supplements.Currently,all supplements of peptone agar are very expensive in the market. | Berhanu Andualem Amare Gessesse | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，10： | 2 |
| 9 | Combinational Flt3 ligand and granulocyte macrophagc colonystimulating factor treatment promotes enhanced tumor in-filtration by dendritic cells and antitumor CD8^+ T-cell cross-priming but is ineffective as a therapy 显示文摘 | BERHANU A HUANG J ALBER S M | 2006 | Cancer Res2006，66，9： | 1 |
| 10 | High helminthic co-infection in tuberculosis patients with undernutritional status in northeastern Ethiopia显示文摘Background:Tuberculosis and parasitosis are the widely distributed diseases in Ethiopia with the leading cause of mortality and morbidity,respectively.There has been no information on the status of co-infections of tuberculosis and parasitosis in Oromia Zone of Amhara Region and South Wollo,Ethiopia.Hence,this study primarily focuses on determining the status of tuberculosis and parasitosis co-infections and associated factors.Methods:The study was conducted in Oromia Special Zone of the Amhara Regional State and South Wollo Zone,northeastern Ethiopia from April 2015 to January 2017.Tuberculosis cases confirmed by health personnel at the health institutions were the source of the study sample.In a cross-sectional study 384 smear positive pulmonary and extra-pulmonary tuberculosis cases were recruited.Faecal specimens provided by the study participants were examined for parasitic co-infections using direct saline microscopic test,Kato-Katz and concentration techniques.Nutritional status was determined using body mass index and mid-upper arm circumferences.Data were analyzed using descriptive statistical methods and Pearson chi-square.Results:Tuberculosis and parasitosis co-infection prevalence was 10.8%,and the proportion of intestinal helminths accounted for 9.7%while intestinal protozoa accounted for 1.9%.Cases with single parasitic infection was 89.3%among co-infected individuals.Co-infection of both disease was not significantly associated with gender and age(P>0.05).The prevalence of undernutrition was 58.6%as determined using body mass index and 73.0%as determined using mid-upper arm circumference with no significant association with gender.Among all forms of tuberculosis cases(384)screened for the study,the bacterial positivity was relatively more common in males(55.5%)than females(44.5%).Tuberculosis lymphadenitis was found to be the most prevalent(85.9%)form of extrapulmonary tuberculosis with cervical adenopathy(75.3%)being the commonly existing disease.Conclusions:The rate of helminthic co-infection is predominantly high than that of intestinal protozoa.Single parasitic co-infection was more common than double or multiple co-infections.Both body mass index and midupper arm circumference anthropometric parameters revealed greater risk of undernutrition in tuberculosis patients.Thus,screening and prompt treatment of parasites in tuberculosis patients and a support of nutritional supplementation for malnourished tuberculosis patients should be further studied which might enhance the disease treatment and minimize the risk of its complexity. | Fikru Gashaw Samuel Bekele Yalemtsehay Mekonnen Girmay Medhin Gobena Ameni Berhanu Erko | 2019 | Infectious Diseases of Poverty2019，8，5： | 1 |
| 11 | ST-246 inhibits in vivopoxvirus dissemination, virus shedding, and systemic diseasemanifestation 显示文摘 | Berhanu A King DS Mosier S | 2009 | Antimicrob Agents Chemother2009，53，12： | 1 |
| 12 | Corneal nerve tortuos- ity in diabetic patients with neuropathy显示文摘 | Kallinikos P Berhanu M O'Donnell C | 2004 | Invest Ophthalmol Vis Sci2004，45，2： | 1 |
| 13 | Cockroaches as carriers of human intestinal parasites in two localities in Ethiopia显示文摘 | Addisu Kinfu Berhanu Erko | 2008 | Transactions of the Royal Society of Tropical Medicine and Hygiene2008，，11： | 1 |
| 14 | Novel alka-line protease from Alkaliphilic bacteria grown onchicken feathcr显示文摘 | Amare G Rajni H K Berhanu A G | 2003 | Enzyme and Microbial Technolo-gy2003，32，： | 1 |
| 15 | Controlling the aggre- gation and rate of release in order to improve insulin formula- tion: molecular dynamics study of full-length insulin amyloid oligomer models显示文摘 | BERHANU W M MASUNOV A E | 2012 | J Mol Model2012，18，3： | 1 |
| 16 | Lab Chip 显示文摘 | Nightingale A M Krishnadasan S H Berhanu D | 2011 | 11(7): 1221-12272011，11，7： | 1 |
| 17 | Corneal nerve tortuosity in diabetic patients with neuropathy显示文摘 | Kallinikos P Berhanu M 0 ' Donnell C | 2004 | Invest Ophthalmol Vis Sci2004，45，： | 1 |
| 18 | Determination of trace levels of dinitrophenolic compounds inenvironmental water samples using hollow fiber supported liquidmembrane extraction and high performance liquid chromatography显示文摘 | BERHANU T LIU J F JONSSON J A K | 2006 | Journal of Chromatography A2006，1103，1： | 1 |
| 19 | Seasonality in Petroleum Futures Spreads 显示文摘 | Berhanu G P Paulson S A | 1999 | The Journal of Futures Markets1999，18，18： | 1 |
| 20 | Increased parasitaemia and delayed parasite clearance in Schistosoma mansoni and Plasmodium berghei co-infected mice显示文摘 | Mengistu Legesse Berhanu Erko Fekede Balcha | 2004 | Acta Tropica2004，，2： | 1 |
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