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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 3 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 4 | Effect of low addition rates of polypropylene fibers on plastic shrinkage cracking and mechanical properties of concrete 显示文摘 | Berke N S Dallaire M P | 1994 | American Concrete Institute Farmington Hills1994，142，： | 1 |
| 5 | Enteroviral protease 2A directly cleaves dystrophin and is inhibited by a dystrophin-based substrate analogue显示文摘 | Badorff C Berkely N Mehrotra S | 2000 | J Bio Chem2000，275，11： | 1 |
| 6 | Corrosion inhibitors in concrete显示文摘 | N S Berke | 1991 | Concrete International1991，13，7： | 1 |
| 7 | The Noxa/ Mcl-1 axis regulates susceptibility to apoptosis under glu- cose limitation in dividing T cells 显示文摘 | ALVES N L DERKS I A BERK E | 2006 | Immunity2006，24，6： | 1 |
| 8 | CD40 ligation activates murine maerophages via an IFN-γ-dependent mechanism resulting in tumor cell destruction in vitro显示文摘 | Buhtoiarov N Lum H Berke G | 2005 | J Immunol2005，174，10： | 1 |
| 9 | Prevention of periopera- tive infection显示文摘 | Fletcher N Sofianos D Berkes MB | 2007 | J Bone Joint Surg Am2007，89，7： | 1 |
| 10 | Comparison of sandblasting,laser irradiation, and conventional acid etching for orthodontic bonding of molar tubes显示文摘 | Berk N Basaran G Ozer T | 2008 | Eur J Orthod2008，30，2： | 1 |
| 11 | Tubule-occluding effect of desensitizing laser treatment on prepared dentin surfaces: an environmental SEM study 显示文摘 | Sipahi C Berk N Ozen J | 2006 | Int J Prosthodont2006，19，1： | 1 |
| 12 | VCAM-1-mediated Rac signaling controls endothelial cell- cellcontacts and leukocyte transmigration显示文摘 | Van Wetering S van den Berk N van Buul jD | 2003 | Am J Physiol Cell Physiol2003，285，8： | 1 |
| 13 | Significance tests for saturated orthogonal arrays 显示文摘 | Berk K N and Picard R R | 1991 | Journal of Quality Technology1991，23，： | 1 |
| 14 | Neural stem cells spontaneously express dopaminergic traits after transplantation into the intact or 6-hydroxydopamine-lesioned rat显示文摘 | Yang M Stull N D Berk M A | 2002 | Exp Neurol2002，177，1： | 1 |
| 15 | Significance tests for saturated orthogonal arrays显示文摘 | BERK K N PICARD R R | 1991 | J Quality Technology1991，23，： | 1 |
| 16 | What Makes Plan Implementation Successful? An Evaluation of Local Plans and Implementation Practices in New Zealand显示文摘 | Berke P Backhurst M Day M Ericksen N Laurian L Crawford J Dixon J | | 0，，04： | 1 |
| 17 | Treatment outcomes in refractive accommodative esotropia显示文摘 | Berk AT Kocak N Ellidokuz H | 2004 | J AAPOS2004，8，4： | 1 |
| 18 | Predicting long-term durability of steel reinforced concrete with calcium nitrite corrosion inhibitor显示文摘 | BERKE N S HICKS M C | 2004 | Cement & Concrete Composites2004，，26： | 1 |
| 19 | Prevention of perioperativeinfection显示文摘 | Fletcher N Sofianos D Berkes MB | 2007 | J Bone Joint Surg(Am)2007，89，： | 1 |
| 20 | Effects of root planing procedures with hand instrument or erbium, chromium:yttriumscandium-gallium-garnet laser irradiation on the root surfaces: a comparative scanning electron microscopy study 显示文摘 | Hakki SS Berk G Dundar N | 2009 | Lasers Med Sci2009，25，3： | 1 |
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