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| 1 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | 2007 (9558)2007，，9558： | 3 |
| 2 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 3 | The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study显示文摘 | Charles N Bernstein James F Blanchard Patricia Rawsthorne Nancy Yu | 2001 | The American Journal of Gastroenterology2001，，4： | 3 |
| 4 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 5 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 6 | On a class of modifying Lagrange interpolation formua 显示文摘 | Bernstein S N | 1954 | Aead Nauk S S S R1954，2，： | 2 |
| 7 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | The Lancet . 2007 (9558)2007，，9558： | 2 |
| 8 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | The Lancet2007，，9558： | 2 |
| 9 | Freeriding in a multi-channel supply chain显示文摘 | Bernstein F Song J S Zheng X N | 2009 | Naval Research Logistics2009，56，8： | 1 |
| 10 | The relationship between inflammatory bowel disease and socioeconomic variables显示文摘 | Charles N Bernstein Allen Kraut James F Blanchard Patricia Rawsthorne Nancy Yu Randy Walld | 2001 | The American Journal of Gastroenterology2001，，7： | 1 |
| 11 | Diversity of the human intestinal microbial flora 显示文摘 | Eckburg P B Bik E M Bernstein C N | 2005 | Science2005，308，： | 1 |
| 12 | The complexity of centralized control of Markov decision processes显示文摘 | Bernstein D S Givan R Immerman N | 2002 | Mathematics of Operations Research2002，，： | 1 |
| 13 | Diversity of the human intestinal microbial flora显示文摘 | Bik E M Bernstein C N | 2005 | Science2005，308，： | 1 |
| 14 | Dynamic fracture of silicon: concurrent simulation of quantum electrons, classical atoms, and the continuum solid 显示文摘 | Abraham F F Bernstein N Broughton J Q | 2000 | MRS Bulletin2000，，5： | 1 |
| 15 | Sur la meilleure approximation de | x | Ppar des polynomes de degres treseleves显示文摘 | Bernstein S N | 1938 | Bull Acad USSR Ser Math1938，2，1： | 1 |
| 16 | The health effects of non-industrial indoor air pollution 显示文摘 | BERNSTEIN J A ALEXIS N BACCHUS H | 2008 | J Allergy Clin Immunol2008，121，3： | 1 |
| 17 | Epigenetic reprogramming in cancer显示文摘 | SuvàML Riggi N Bernstein BE | 2013 | Science2013，339，6127： | 1 |
| 18 | Sur la meilleure approximation de |x| par des polyn6mes de degres donnes显示文摘 | Bernstein S N | 1913 | Acta Math1913，37，： | 1 |
| 19 | Rule based expert systems for network management and operations:an introduction显示文摘 | R N Cronk P H Callan L Bernstein | 1993 | IEEE Network1993，，： | 1 |
| 20 | Sur la meilleure approximation de| x | par des polynomes de degres donnes显示文摘 | Bernstein S N | 1913 | Acta Math1913，37，1： | 1 |
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