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| 1 | Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review显示文摘AIM To critically assess the available literature regarding the efficacy of thioguanine treatment in inflammatory bowel disease(IBD) patients, irrespective of the(hepato-) toxicity profile.METHODS A systematic literature search of the MEDLINE database using Pub Med was performed using the keywords 'thioguanine', '6-TG', 'thioguanine', 'inflammatory bowel disease', 'IBD', 'Crohn's disease', 'Ulcerative colitis' and 'effectiveness' in order to identify relevant articles published in English starting from 2000. Reference lists of the included articles were crosschecked for missing articles. Reviewed manuscripts concerning the effectiveness of thioguanine treatment in IBD were reviewed by the authors and the data were extracted. Data were subsequently analyzed with descriptive statistics. Due to the lack of standardized outcomes, a formal meta-analysis was not performed.RESULTS A total of 11 applicable studies were found that involved the effectiveness of thioguanine therapy in IBD. Eight studies were conducted in a prospectivemanner, in the remaining three studies, data was collected retrospectively. In total, 353 IBD-patients(225 patients with Crohn's disease, 119 with ulcerative colitis and nine with unclassified IBD) with prior azathioprine/mercaptopurine resistance and/or intolerance(n = 321) or de novo thioguanine administration(n = 32) were included for analysis, of which 228(65%) had clinical improvement on thioguanine therapy, based on standard IBD questionnaires, biochemical parameters or global physician assessments. Short-term results were based on 268 treatment years(median follow-up 9 mo, range 3-22 mo) with a median daily dose of 20 mg(range 10-80 mg). Discontinuation, mostly due to adverse events, was reported in 72 patients(20%). CONCLUSION The efficacy of thioguanine therapy in IBD patients intolerant to conventional thiopurine therapy is observed in 65%, with short term adverse events in 20% of patients. | Berrie Meijer Chris JJ Mulder Godefridus J Peters Adriaan A van Bodegraven Nanne KH de Boer | 2016 | World Journal of Gastroenterology2016，22，40： | 5 |
| 2 | Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association显示文摘 | Véronique L. Roger Alan S. Go Donald M. Lloyd-Jones Robert J. Adams Jarett D. Berry Todd M. Brown Mercedes R. Carnethon Shifan Dai Giovanni de Simone Earl S. Ford Caroline S. Fox Heather J. Fullerton Cathleen Gillespie Kurt J. Greenlund Susan M. Hailpern | 2011 | Circulation2011，，4： | 4 |
| 3 | 应用ICF扩大慢性神经性疾病中健康问题范围的研究显示文摘目的确定能够显示慢性神经功能障碍(多发性硬化症、帕金森氏病和神经肌肉疾病)患者有关健康问题的ICF类目。方法采用Delphi研究方法,由三方面与疾病相关的人组成专家小组,即患者及其代理人、医疗和非医疗卫生专业人士(n=98)。小组要求根据《国际功能,残疾和健康分类》(ICF)反映有关特定疾病的健康问题,选择相关类目。小组成员将这些类目与简明残疾记录量表(MRD)和残疾及其影响量表(DIP)两种测量工具中的指标作比较。结果选择出68项ICF类目相关性最大,分别属于四个ICF领域。患者/代理人和卫生专业人员两者评价的类目无显著性差异。疾病小组的一致性很高。三个特定疾病小组的选择在'身体功能和结构'领域存在差异,但如果扩大纳入标准则可以达成共识。所选择的ICF项目涵盖了几乎所有测量项目。最大的差异表现在'参与'和'环境因素'领域选择的类目。结论与广泛应用于神经学领域的健康状态测量相比,在研究健康问题时所选择的ICF类目更为广泛,特别是涉及ICF的'参与'和'环境因素'领域时。 | Klaske WYNIA Berrie MIDDEL Jitse P. van DIJK Han de RUITER Willem LOK Jacques Ha de KEYSER Sijmen A. REIJNEVELD 王朴(译) 张君梅(译) 荀芳(译) 邱卓英(审校) 李建军(审校) | 2008 | 中国康复理论与实践2008，14，12： | 2 |
| 4 | Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles显示文摘为特定的基因 silencing 的小介入 RNA (siRNAs ) 的治疗学的诺言依赖于到细胞质的功能的 siRNAs 的成功的交货。他们到一个确定的交货平台的变化形式例如金 nanoparticles,为治疗疾病并且推进我们细胞的过程的理解提供巨大的潜力。他们的成功或失败依赖于两个进房间和功能的 siRNA 的随后的细胞内部的版本的 nanoparticles 的举起。在这研究,利用金 nanoparticle 对 C-MYC 的 调停siRNA 的交货,我们试图决定我们是否能完成在一个癌症房间击倒与细胞内部的谷胱甘肽的底层排队,并且如果有的话,聚乙烯乙二醇(木钉)决定影响 ligand 密度在上击倒,考虑到决定最佳的 nanoparticle 设计完成 C-MYC 击倒。我们表明那,不管木钉密度,在有相对低的谷胱甘肽层次的房间击倒能被完成,以及为在细胞内部的环境的劈开的 siRNA 的可获得性上的木钉的位的阻碍者的可能的效果。当击倒时,金 nanoparticle 举起经由传播电子显微镜学和集体光谱学被表明被在里面房间 westerns 和 BrdU 加入分别地在蛋白质和生理的层次(在 S 阶段的房间) 决定。 | Mark McCully Yulan Hernandez Joao Conde Pedro V. Baptista Jesus M. de la Fuente Andrew Hursthouse David Stirling Catherine C. Berry | 2015 | Nano Research2015，8，10： | 2 |
| 5 | 一般人群中发生心力衰竭的10年风险方程显示文摘目前急需能减轻心力衰竭负担的一级预防策略,但未见实用有效的风险预测工具。该研究旨在得出一个计算心力衰竭事件发生的10年风险方程。研究者根据7个社区队列,至少12年随访的个体水平数据,推导并验证了心力衰竭的种族和性别特异性10年风险方程。1985-2000年间招募年龄30~79岁在基线时无心血管病的研究对象,创建一个集合队列并随机分组以进行方程推导和内部验证。在另两个队列中也评估了该模型的性能。 | Khan SS Ning H Shah SJ Yancy CW Carnethon M Berry JD Mentz RJ O’Brien E Correa A Suthahar N de Boer RA Wilkins JT Lloyd-Jones DM 刘青 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 1 |
| 6 | Correlation of clinical parameters of disease activity in rheumatoid arthritis with serum concentration of C-reactive protein and erythrocyte sedimentation rate显示文摘 | Mallya RK de Beer FC Berry H | 1982 | J Rheumatol1982，9，2： | 1 |
| 7 | Supercritical fluid chromatographic and supercritical fluid-mass spectrometric studies of some polar compounds显示文摘 | Berry A J Games DE Perkins JR | 1986 | Journal of Chromatography1986，363，： | 1 |
| 8 | Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer 显示文摘 | Tannock IF de Wit R Berry WR | 2004 | N Engl J Med2004，351，15： | 1 |
| 9 | Tat peptide as an efficient molecule to translocate gold nanoparticles into the cell nucleus 显示文摘 | de la Fuente JM Berry CC | 2005 | Bioconjug Chem2005，16，： | 1 |
| 10 | Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer显示文摘 | Tannock IF de Wit R Berry WR | 2004 | N Engl J Med2004，351，： | 1 |
| 11 | Tat peptide as an efficient molecule to translocate gold nanoparticles into the cell nucleus 显示文摘 | De la Fuente JM Berry CC | 2005 | Bioconjug Chem2005，16，5： | 1 |
| 12 | Effect of time between human chorionoic gonadoropin injection and egg retrieval is age dependent显示文摘 | Reichman DE Missmer SA Berry KD | 2011 | Fertil Steril2011，95，6： | 1 |
| 13 | Structure, diversity and evolution of protein toxins from spore-forming ento- mopathogenie bacteria显示文摘 | De Maagd R A Bravo A Berry C | 2003 | Annual Review of Genetics2003，37，： | 1 |
| 14 | Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer显示文摘 | Tannock IF de Wit R Berry WR | 2004 | N Engl J Med2004，351，15： | 1 |
| 15 | Doeetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer显示文摘 | Tannoek IF de Wit R Berry WR | 2004 | N Engl J Med2004，351，15： | 1 |
| 16 | Pathological features and inhaled corticosteroid response of eosinophilic and non- eosinophilic asthma显示文摘 | Berry M Morgan A Shaw DE | 2007 | Thorax2007，62，： | 1 |
| 17 | Cerebral Autoregulation in Stroke: A Review of Transcranial Doppler Studies显示文摘 | Marcel J.H. Aries Jan W. Elting Jacques De Keyser Berry P.H. Kremer Patrick C.A.J. Vroomen | 2010 | Stroke2010，，： | 1 |
| 18 | Correlation of clinical parameters of disease activity in rheumatoid arthritis with serum concentration of C-reactive protein and erythrocyte sedimentation rate显示文摘 | Mallya RK De Beer FC Berry H | | 0，，02： | 1 |
| 19 | Low molecular weight heparin (bemiparin sodium)and coagulation profile of patients with heart failure显示文摘 | De Lorenzo F New berry D Scully M | 2002 | Am Heart J2002，143，4： | 1 |
| 20 | Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma显示文摘 | Berry M Morgan A Shaw DE | 2007 | Thorax2007，62，12： | 1 |
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