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| 1 | Spontaneous ovarian hyperstimulation syndrome and pituitary hyperplasia mimicking macroadenoma associated with primary hypothyroidism显示文摘We report an unusual case of spontaneous ovarian hyperstimulation syndrome and pituitary hyperplasia mimicking macroadenoma in an adult,non-pregnant woman.Her condition was triggered by unrecognized primary hypothyroidism,which regressed after thyroid hormone replacement therapy.This case highlights the need for clinicians and radiologists to familiarize themselves with the clinical and imaging features detected in case of these complications of primary hypothyroidism,which are not well known in the medical and radiological profession.Such improved knowledge will help avoid delays in diagnosis,progression to lifethreatening complications,and unnecessary surgery. | Rene Epunza Kanza Sylvain Gagnon Helene Villeneuve David Laverdiere Isabelle Rousseau Edith Bordeleau Michel Berube | 2013 | World Journal of Radiology2013，5，1： | 8 |
| 2 | Watt-level and spectrally flat mid-infrared supercontinuum in fluoroindate fibers显示文摘We report on infrared supercontinuum(SC) generation in step-index fluoroindate-based fiber by using an all-fiber laser source. In comparison to widely used ZBLAN fibers for high-power mid-infrared(MIR) SC generation, fluoroindate fibers have multiphoton absorption edges at significantly longer wavelengths and can sustain similar intensities. Recent developments highlighted in the present study allowed the production of fluoroindate fibers with MIR background loss of 2 dB/km, which is similar to or even better than ZBLAN fibers.By using an all-fiber picosecond laser source based on an erbium amplifier followed by a thulium power amplifier,we demonstrate the generation of 1.0 W infrared SC spanning over 2.25 octaves from 1 μm to 5 μm. The generated MIR SC also exhibits high spectral flatness with a 6 dB spectral bandwidth from 1.91 μm to 4.77 μm and an average power two orders of magnitude greater than in previous demonstrations with a similar spectral distribution. | FRANCIS THEBERGE NANCY BERUBE SAMUEL POULAIN SOLENN COXIC LOUIS-RAFAEL ROBICHAUD MARTIN BERNIER REAL VALLEE | 2018 | Photonics Research2018，6，6： | 5 |
| 3 | Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis显示文摘While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely unknown.Hence,we sought to determine the effects of NOD1 on metastasis.NOD1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOD1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOD1.C12-iE-DAP,a highly selective NOD1 ligand derived from gram-negative bacteria,was used to activate NOD1.ML130,a specific NOD1 inhibitor,was used to block C12-iE-DAP stimulation.Stable knockdown(KD)of NOD1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus repeated.Lastly,the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase inhibitors.Our data demonstrate that NOD1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell lines.Clinically,we demonstrate that this increased NOD1 expression negatively impacts survival in patients with CRC.Subsequently,we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion,migration and metastasis.These effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)pathway.This is the first study implicating NOD1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target. | Henry Y.Jiang Sara Najmeh Guy Martel Elyse MacFadden-Murphy Raquel Farias Paul Savage Arielle Leone Lucie Roussel Jonathan Cools-Lartigue Stephen Gowing Julie Berube Betty Giannias France Bourdeau Carlos HFChan Jonathan D.Spicer Rebecca McClure Morag Park Simon Rousseau Lorenzo E.Ferri | 2020 | Protein & Cell2020，11，3： | 3 |
| 4 | Nonlinear increase,invisibility,and sign inversion of a localized fs-laser-induced refractive index change in crystals and glasses显示文摘Multiphoton absorption via ultrafast laser focusing is the only technology that allows a three-dimensional structural modification of transparent materials.However,the magnitude of the refractive index change is rather limited,preventing the technology from being a tool of choice for the manufacture of compact photonic integrated circuits.We propose to address this issue by employing a femtosecond-laser-induced electronic band-gap shift(FLIBGS),which has an exponential impact on the refractive index change for propagating wavelengths approaching the material electronic resonance,as predicted by the Kramers–Kronig relations.Supported by theoretical calculations,based on a modified Sellmeier equation,the Tauc law,and waveguide bend loss calculations,we experimentally show that several applications could take advantage of this phenomenon.First,we demonstrate waveguide bends down to a submillimeter radius,which is of great interest for higher-density integration of fs-laser-written quantum and photonic circuits.We also demonstrate that the refractive index contrast can be switched from negative to positive,allowing direct waveguide inscription in crystals.Finally,the effect of the FLIBGS can compensate for the fs-laser-induced negative refractive index change,resulting in a zero refractive index change at specific wavelengths,paving the way for new invisibility applications. | Jerome Lapointe Jean-Philippe Berube Yannick Ledemi Albert Dupont Vincent Fortin Younes Messaddeq Real Vallee | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 5 | Inhaled particulate matter causes expression of nuclear factor (NF)-Kappa B related genes and oxidant dependent NF-Kappa B activation in vitro 显示文摘 | Shukla A Timblin C Berube K | 2000 | Am J Respir Cell Mol Biol2000，23，： | 1 |
| 6 | Inhibition of in vivo fertilization by active immunization of male hamsters against a 26-kDa sperm glycoprotein 显示文摘 | BERUBE B SULLIVAN R | 1994 | Biol Reprod1994，51，6： | 1 |
| 7 | Hamster sperm antigen P26h is a phosphatidylinositol-anchored protein 显示文摘 | LEGARE C BERUBE B LEFIEVRE L | 1999 | Mol Reprod Dev1999，52，2： | 1 |
| 8 | Ammonia oxidation kinetics determine niche separation of nitrifying Archaea and Bacteria显示文摘 | Martens-Habbena W Berube PM Urakawa H | 2009 | Nature2009，461，7266： | 1 |
| 9 | Down - regulation of CD9 expression during prostate carcinoma progression is associated with CD9 mRNA modifications显示文摘 | Wang J C Begin L R Berube N G | 2007 | Clin Cancer Res2007，13，8： | 1 |
| 10 | Evaluation of the validity of the pore solution expression method from hardened cement pastes and mortars显示文摘 | DUCHESNE J BERUBE M A | 1994 | Cement and Concrete Research1994，24，3： | 1 |
| 11 | Extending and evaluating a warfarin dosing algorithm that includes CYP4F2 and pooled rare variants of CYP2C9显示文摘 | Sagreiya H Berube C Wen A | 2010 | Pharmacogenet Genomics2010，20，7： | 1 |
| 12 | Are Firms that Re- ceived R&D Subsidies More Innovative? 显示文摘 | Berube Charles and Pierre Mohnen | 2009 | Canadian Jour- nal of Economics2009，42，： | 1 |
| 13 | Measurement of the Alkali Content of Concrete Using Hot-Water Extraction显示文摘 | Berube M A Frenette J Rivest M | 2002 | Cement Concrete and Aggregate2002，24，1： | 1 |
| 14 | Segment of rat chromosome 20 regulates diet-induced augmentations in adiposity,glucose intolerance,and blood pressure显示文摘 | Sedova L Berube J | 2003 | Hypertension2003，41，： | 1 |
| 15 | Rapid evaluation of the threshold Alkali level for Alkali-reactive siliceous aggregates in concrete显示文摘 | BERUBE M A | 1999 | Cement Concrete and Composites1999，，21： | 1 |
| 16 | Decrease of pore solution alkalinity in concrete tested for alkali-silica reaction 显示文摘 | Rivard P Berube M A Ollivier J P | 2007 | Materials and Structures2007，40，9： | 1 |
| 17 | Measurement of reduced sulphur compounds contained in aqueous matrices by direct injection into a gas chromatograph with a flame photometric detector显示文摘 | Berube PR Parkinson PD Hall ER | 1999 | J Chromatogr A1999，830，830： | 1 |
| 18 | Effectof the synthesis conditions on the redox and catalytic properties in oxidation reactions of LaCo1-x FexO3显示文摘 | Sebastien Royer Francois Berube Serge Kaliaguine | 2005 | Applied CatalysisA: General2005，282，： | 1 |
| 19 | Effect of the synthesis conditions on the redox and catalytic properties in oxidation reactions of La Co1-xFex O3显示文摘 | Sebastien Royer Francois Berube Serge Kaliaguine | 2005 | Applied Catalysis A:General2005，282，： | 1 |
| 20 | Available alkalis from supplementarycementing materials 显示文摘 | Duchesne J Berube M A | 1994 | ACI Materials Journal1994，91，3： | 1 |
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