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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | A theory for the ablation of glassy materials显示文摘 | BETHE H A ADAMS M C | 1959 | Journal of the Aero/Space Sciences1959，26，6： | 1 |
| 3 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 4 | Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation显示文摘 | André Ballesteros-Tato Beatriz León Beth A. Graf Amy Moquin Pamela Scott Adams Frances E. Lund Troy D. Randall | 2012 | Immunity2012，，5： | 1 |
| 5 | A theory for the ablation of glassy materials 显示文摘 | Bethe H A Adams M C | 1959 | Journal of Aerospace Sciences1959，26，6： | 1 |
| 6 | A Theory for the Ablation of Glassy Ma- terials显示文摘 | Bethe H A Adams M C | 1959 | Journal of the Aero/Space Sciences1959，26，6： | 1 |
| 7 | Ecological issues related to N deposition to natural ecosystems:research needs显示文摘 | Mary Beth Adams | 2003 | Environment International2003，29，： | 1 |
| 8 | Nerve Growth Factor Accelerates Seizure Development, Enhances Mossy Fiber Sprouting, and Attenuates Seizure induced decreases in Neuronal Density in the Kindling Model of Epilepsy 显示文摘 | Beth Adams Mona Sazgar Philip Osehobo | 1997 | Society for Neuroscience1997，17，14： | 1 |
| 9 | A high response rate to liposomal doxorubicin is seen among women with BRCA mutations treated for recurrent epithelial ovarian cancer显示文摘 | Sarah F. Adams Evelyn B. Marsh Wafic Elmasri Steffanie Halberstadt Stephanie VanDecker Mary D. Sammel Angela R. Bradbury Mary Daly Beth Karlan Stephen C. Rubin | 2011 | Gynecologic Oncology2011，，3： | 1 |
| 10 | A theory for the ablation of glassy materials显示文摘 | Bethe H A Adams M C | 1959 | Journal of the Aero/Space Sciences1959，26，32： | 1 |
| 11 | Principles of Arrhythmia Management During Pregnancy显示文摘This paper reviews current recommendations on the appropriate evaluation and management of cardiac arrhythmias in the pregnant patient.Most arrhythmias during pregnancy are benign and require no intervention.When required,the decision to treat should be based on symptom severity and the associated risk to mother and fetus posed by potentially recurring arrhythmia episodes throughout the pregnancy.Any treatment strategy in this patient population has inherent risk to both mother and unborn child.Before the initiation of any intervention,documentation of a clinical arrhythmia and correlation with clinical symptoms should be obtained.There is no role for empiric therapy. | Thomas Adam Burkart,MD,FACC,FHRS William M.Miles,MD,FACC,FHRS Jamie Beth Conti,MD,FACC,FHRS | 2016 | Cardiovascular Innovations and Applications2016，，B02： | 0 |
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